Changes in telomerase activity of advanced cancers of oral cavity and oropharynx during radiation therapy: correlation with clinical outcome.

Ogawa, Yasuhiro; Nishioka, Akihiko; Hamada, Norihiko; M, Terashima; Inomata, Taisuke; Shoji, Yasuhiro; Seguchi, H; Kishimoto, Shun

doi:10.3892/ijmm.2.3.301

Cited by 8 publications

(7 citation statements)

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“…Current literature indicates that telomerase has a radiationinducible function lead to resistance of cells to irradiation. Ogawa et al (1998) reported that the advanced cancers of oral cavity and oropharynx with higher telomerase activity were not sensitive to radiation therapy but the other cancers with lower telomerase activity were sensitive to radiotion therapy. Rubio and colleagues (Rubio et al, 2004) reported that high telomerase activity provided DOI:http://dx.doi.org/10.7314/APJCP.2012.13.12.5975 siRNA-mediated Inhibtion of hTERC Enhances Radiosensitivity of Cervical Cancer resistance to irradiation in human fibroblasts with short telomeres, and this resistance was dependent on the ability of telomerase to maintain telomere functionality.…”

Section: Discussionmentioning

confidence: 99%

siRNA-mediated Inhibition of hTERC Enhances Radiosensitivity of Cervical Cancer

Chen¹,

Liu²

2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

siRNA-mediated Inhibition of hTERC Enhances Radiosensitivity of Cervical Cancer

Chen¹,

Liu²

2012

Asian Pacific Journal of Cancer Prevention

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“…Several studies have, indeed, reported that TERT mRNA levels and telomerase activity are higher in poorly differentiated SCC [ 63 , 126 , 143 , 146 , 166 – 169 ], increase with tumor stage [ 63 , 131 , 142 , 166 ], and are associated with lymph node involvement [ 63 , 126 , 131 , 137 , 139 , 170 ] or extracapsular extension of lymph node metastases [ 125 ]. Numerous studies have analyzed telomerase’s ability to predict outcome (Table 1 ) [ 46 , 63 , 125 , 127 , 130 , 136 , 139 , 140 , 144 , 171 – 177 ], and most have reported a correlation between increased telomerase expression and activity and a reduced response to treatment and a higher rate of regional and distant metastases ultimately resulting in poor clinical outcome [ 63 , 125 , 127 , 136 , 144 , 171 , 173 – 176 ]. A study examining a large sample of neoplastic tissues from 217 HNSCC patients reported that telomerase activity was an independent predictor of poor survival after adjustment was made for age, site, stage, histological grade, tumor depth, and extracapsular extension [ 125 ].…”

Section: Telomerase In Hnsccmentioning

confidence: 99%

Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications

Boscolo‐Rizzo¹,

Mosto²,

Rampazzo

et al. 2016

Cancer Metastasis Rev

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Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a frequently lethal, heterogeneous disease whose pathogenesis is a multistep and multifactorial process involving genetic and epigenetic events. The majority of HNSCC patients present with locoregional advanced stage disease and are treated with combined modality strategies that can markedly impair quality of life and elicit unpredictable results. A large fraction of those who undergo locoregional treatment and achieve a complete response later develop locoregional recurrences or second field tumors. Biomarkers that are thus able to stratify risk and enable clinicians to tailor treatment plans and to personalize post-therapeutic surveillance strategies are highly desirable. To date, only HPV status is considered a reliable independent predictor of treatment response and survival in patients with HNSCC arising from the oropharyngeal site. Recent studies suggest that telomere attrition, which may be an early event in human carcinogenesis, and telomerase activation, which is detected in up to 90 % of malignancies, could be potential markers of cancer risk and disease outcome. This review examines the current state of knowledge on and discusses the implications linked to telomere dysfunction and telomerase activation in the development and clinical outcome of HNSCC.

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“…al. 26 reported that the advanced cancers of oral cavity and oropharynx with higher telomerase activity were not sensitive to radiation therapy but the other cancers with lower telomerase activity were sensitive to radiation therapy. Human cervical carcinoma is a common high-risk malignancy in gynecology and its main therapeutic method is radiotherapy.…”

confidence: 99%

The therapeutic potential of survivin promoter-driven siRNA on suppressing tumor growth and enhancing radiosensitivity of human cervical carcinoma cells via downregulating hTERT gene expression

Wang

Lin²,

Wang³

et al. 2007

Cancer Biology & Therapy

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Human telomerase is a ribonucleoprotein complex composed of two subunits, an RNA component (hTR) and a human telomerase reverse transcriptase component (hTERT). The activation of telomerase, a process regulated by the human telomerase reverse transcriptase (hTERT), is a crucial step during cellular immortalization and malignant transformation. hTERT is overexpressed in most malignant cells but undetectable in most normal somatic cells. To explore its possibility as a therapeutic target for human cervical carcinoma, we developed a novel tumor-specific RNA interference system targeting hTERT by using the survivin promoter and investigated the effects of it on the proliferation, apoptosis and radiosensitivity in human cervical carcinoma cells (HeLa). The treatment of HeLa cells by hTERT gene RNAi not only could inhibit the proliferation of human cervical carcinoma cells (HeLa), but also could enhance the radiosensitivity of those cells via downregulation of their mRNA and protein expression. Therefore, survivin promoter-driven siRNA expression vector targeting hTERT may have potential use in radiosensitization therapy with targeted tumor gene silencing effect in human cervical carcinomas.

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Changes in telomerase activity of advanced cancers of oral cavity and oropharynx during radiation therapy: correlation with clinical outcome.

Cited by 8 publications

References 0 publications

siRNA-mediated Inhibition of hTERC Enhances Radiosensitivity of Cervical Cancer

siRNA-mediated Inhibition of hTERC Enhances Radiosensitivity of Cervical Cancer

Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications

The therapeutic potential of survivin promoter-driven siRNA on suppressing tumor growth and enhancing radiosensitivity of human cervical carcinoma cells via downregulating hTERT gene expression

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