Changes in systolic arterial pressure variability are associated with the decreased aerobic performance of rats subjected to physical exercise in the heat

Müller-Ribeiro, Flávia Camargos de Figueirêdo; Wanner, Samuel Penna; Santos, Weslley H M; Lima, Milene Rodrigues Malheiros; Fonseca, Ivana Alice Teixeira; Coimbra, Cândido Celso; Pires, Washington

doi:10.1016/j.jtherbio.2016.11.006

Cited by 6 publications

(7 citation statements)

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“…Laboratory rodents, including rats, are commonly used to investigate the mechanisms underlying physical exercise-induced physiological responses, such as cardiovascular and thermoregulatory responses, [1][2][3][4][5][6] particularly in experiments involving invasive procedures. 7 Such studies provide important contributions to our understanding of the central mechanisms involved in the regulation of core body temperature (T CORE ) [8][9][10] and mean arterial pressure (MAP) 11,12 during physical exercise.…”

Section: Introductionmentioning

confidence: 99%

Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats

et al. 2017

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2018) Preexercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats, Temperature, 5:2, 109-122, ABSTRACT Different methodological approaches have been used to conduct experiments with rats subjected to treadmill running. Some experimenters have exposed rats to the treadmill setup before initiating exercise to minimize the influences of handling and being placed in an anxiety-inducing environment on the physiological responses to subsequent running. Other experimenters have subjected rats to exercise immediately after placing them on the treadmill. Thus, the present study aimed to evaluate the effects of pre-exercise exposure to the treadmill on physical performance and cardiovascular and thermoregulatory responses during subsequent exercise. Male Wistar rats were subjected to fatiguing incremental-speed exercise at 24 C immediately after being placed on the treadmill or after being exposed to the treadmill for 70 min following removal from their home cages. Core body temperature (T CORE ), tail-skin temperature (T SKIN ), heart rate (HR) and mean arterial pressure (MAP) were recorded throughout the experiments. Rats exposed to the treadmill started exercise with higher T CORE , lower HR and MAP, and unaltered T SKIN . This exposure did not influence performance, but it markedly affected the exercise-induced increases in the four physiological parameters evaluated; for example, the T SKIN increased earlier and at a higher T CORE . Moreover, previous treadmill exposure notably allowed expected exercise-induced changes in cardiovascular parameters to be observed. Collectively, these data indicate that pre-exercise exposure to the treadmill induces important effects on physiological responses during subsequent treadmill running. The present data are particularly relevant for researchers planning experiments involving physical exercise and the recording of physiological parameters in rats.

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Section: Introductionmentioning

confidence: 99%

Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats

et al. 2017

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“…The LF-to-HF ratio of pulse interval variability was calculated to assess the sympatho-vagal balance in the heart (Montano et al, 1994 ). These bandwidths have previously been used to analyze the blood pressure spectrum and HR variability in rats (Ceroni et al, 2009 ; Tezini et al, 2013 ; Müller-Ribeiro et al, 2017 ). Integration of the power spectrum density within each frequency bandwidth was achieved using Cardioseries software (version 2.2; Ribeirão Preto, SP, Brazil).…”

Section: Methodsmentioning

confidence: 99%

“…The baroreflex gain was determined from spontaneous changes in blood pressure and the pulse interval using a time-series method designed for the rat (Oosting et al, 1997 ; Waki et al, 2006 ; Müller-Ribeiro et al, 2017 ). First, spontaneously occurring ramps of either decreasing or increasing blood pressure of four beats were used to calculate the baroreceptor reflex sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Physical Exercise-Induced Cardiovascular and Thermoregulatory Adjustments Are Impaired in Rats Subjected to Cutaneous Artery Denervation

et al. 2018

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This study aimed to investigate the chronic effects of caudal artery denervation on morphometric parameters of the tail vascular smooth muscle and on physical exercise-induced thermoregulatory and cardiovascular adjustments in rats. Male Wistar rats were subjected to caudal artery denervation or the sham procedure. Approximately 26–28 days after these procedures, their thermoregulatory and cardiovascular parameters were evaluated at rest and during or following a fatiguing treadmill run. At the end of the experiments, the rats were euthanized, and samples of their tails were removed to evaluate morphometric parameters of the vascular smooth muscle surrounding the caudal artery. Denervated rats showed morphological adaptations, including increased arterial wall thickness and wall-to-lumen ratios. In resting rats and following the fatiguing exercise, caudal artery denervation barely affected the thermoregulatory and cardiovascular parameters evaluated. By contrast, caudal artery denervation attenuated the increase in tail skin temperature, decreased the spontaneous baroreflex sensitivity, and exacerbated the increases in mean arterial pressure in exercising rats. The increased wall-to-lumen ratio of denervated rats correlated negatively with the maximum tail skin temperature attained or cutaneous heat loss sensitivity but correlated positively with the maximum diastolic blood pressure attained during exercise. In conclusion, cutaneous denervation induces vascular remodeling characterized by morphological adaptations of the tail vascular smooth muscle. This vascular remodeling likely underlies the impaired tail heat loss and blood pressure adjustments in denervated rats subjected to physical exercise. Therefore, we have highlighted the importance of cutaneous vascular innervation integrity in thermal and cardiovascular control in stress-challenged rats. In this sense, our findings advance the understanding of thermoregulatory and cardiovascular system reactions after a sustained cutaneous vascular innervation injury, which is essential for the treatment of some diseases, such as Parkinson's disease and type 1 and type 2 diabetes mellitus.

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“…All calculations were performed according to the standard methods adopted for the analysis of human HRV. However, due to the fact that the heart rate in rats is about 5 times higher than in humans, some coefficients in the calculations were adjusted to account for this difference [20], [21]. The selected bands and the corresponding standard ranges for spectral HRV parameters in rats are presented in Table 3.…”

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confidence: 99%

Physical Training Reverses the Impaired Cardiac Autonomic Control and Exercise Tolerance Induced by Right-Side Vagal Denervation

et al. 2022

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Cardiac transplantation results in inevitable denervation. However, it remains poorly understood how important the loss of vagal innervation is for exercise tolerance. It is also unclear whether physical working capacity restoration after denervation is assured during exercise. To assess the effect of denervation on cardiac autonomic control and exercise tolerance, we used an animal model of cardiac denervation by unilateral transection of the vagus nerve. The experimental study was carried out on male Wistar rats (N = 60), which were randomly assigned to six groups. One third of animals constituted the control group, the other third underwent right-side vagal denervation, and the rest underwent left-side denervation. After the surgery, half of the animals were trained and the other half were kept sedentary. Electrocardiogram was recorded in all animals, followed by assessment of the heart rate variability. It was shown that the rightside denervation leads to significant decrease in the heart rate variability. The postsurgical maintenance of rats with the right-side denervation in sedentary conditions led to significant decreased exercise tolerance. An increase in the physical working capacity was found in all trained animals but the most significant increase was again observed in rats with the right-side denervation. Moreover, in all trained animals indices of the heart rate variability were significantly higher. These observations allow us to conclude that right-side vagal denervation leads to both a decrease in the cardiac autonomic control and a suppression of physical working capacity. Postsurgical training with submaximal intensity promotes both restoration of the exercise tolerance in all animals and increase in the regulatory neurogenic influences on the sinus node, including rats undergoing vagal denervation.

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Changes in systolic arterial pressure variability are associated with the decreased aerobic performance of rats subjected to physical exercise in the heat

Cited by 6 publications

References 77 publications

Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats

Pre-exercise exposure to the treadmill setup changes the cardiovascular and thermoregulatory responses induced by subsequent treadmill running in rats

Physical Exercise-Induced Cardiovascular and Thermoregulatory Adjustments Are Impaired in Rats Subjected to Cutaneous Artery Denervation

Physical Training Reverses the Impaired Cardiac Autonomic Control and Exercise Tolerance Induced by Right-Side Vagal Denervation

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