Changes in subthalamic activity during movement observation in Parkinson’s disease: Is the mirror system mirrored in the basal ganglia?

Alegre, Manuel; Rodríguez-Oroz, M.C.; Valencia, Miguel; Pérez-Alcázar, Marta; Guridi, Jorge; Iriarte, Jorge; Obeso, José A.; Artieda, Julio

doi:10.1016/j.clinph.2009.11.013

Cited by 97 publications

(79 citation statements)

References 53 publications

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“…6 D; supplemental Fig. 3, available at www.jneurosci.org as supplemental material), as the low-beta band frequency was modulated by movement (Foffani et al, 2005;Alegre et al, 2010). Despite this movement-related decrease, the magnitude of the MI was still highly significant.…”

Section: Analysis Of the Movement-related Changesmentioning

confidence: 98%

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

Tainta²,

et al. 2010

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In Parkinson's disease (PD), the oscillatory activity recorded from the basal ganglia shows dopamine-dependent changes. In the "off" parkinsonian motor state, there is prominent activity in the beta band (12-30 Hz) that is mostly attenuated after dopaminergic therapy ("on" medication state). The on state is also characterized by activity in the gamma (60 -80 Hz) and high-frequency (300 Hz) bands that is modulated by movement. We recorded local field potentials from a group of 15 PD patients (three females) treated with bilateral deep brain stimulation of the subthalamic nucleus, using a high sampling rate (2 kHz) and filters suitable to study high-frequency activity (0.3-1000 Hz). We observed high-frequency oscillations (HFOs) in both the off and on motor states. In the off state, the amplitude of the HFOs was coupled to the phase of the abnormal beta activity. The beta-coupled HFOs showed little or even negative movement-related changes in amplitude. Moreover, the degree of movement-related modulation of the HFOs correlated negatively with the rigidity/ bradykinesia scores. In the on motor state, the HFOs were liberated from this beta coupling, and they displayed marked movementrelated amplitude modulation. Cross-frequency interactions between the phase of slow activities and the amplitude of fast frequencies have been attributed an important role in information processing in cortical structures. Our findings suggest that nonlinear coupling between frequencies may not only be a physiological mechanism (as shown previously) but also that it may participate in the pathophysiology of parkinsonism.

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Section: Analysis Of the Movement-related Changesmentioning

confidence: 98%

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

Tainta²,

et al. 2010

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“…A beta ERD was observed during movement initiation and ERS during movement termination [16,33,34,35]. Moreover, when patients were cued not to move following movement preparation, a significant synchronization was observed in the beta-frequency band [20,21,22,36].…”

Section: Lfp and Parkinson's Diseasementioning

confidence: 99%

Clinical Implications of Local Field Potentials for Understanding and Treating Movement Disorders

Thompson

Lanctin

Ince

et al. 2014

Stereotact Funct Neurosurg

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Background: Deep brain stimulation (DBS) for the treatment of movement disorders has provided researchers with an opportunity to record electrical oscillatory activity from electrodes implanted in deep brain structures. Extracellular activity recorded from a population of neurons, termed local field potentials (LFPs), has shed light on the pathophysiology of movement disorders and holds the potential to lead to refinement in existing treatments. Objective: This paper reviews the clinical significance of LFPs recorded from macroelectrodes implanted in basal ganglia and thalamic targets for the treatment of Parkinson's disease, essential tremor and dystonia. Methods: Neural population dynamics and subthreshold events, which are undetectable by single-unit recordings, can be examined with frequency band analysis of LFPs (frequency range: 1-250 Hz). Results: Of clinical relevance, reliable correlations between motor symptoms and components of the LFP power spectrum suggest that LFPs may serve as a biomarker for movement disorders. In particular, Parkinson's rigidity has been shown to correlate with the power of beta oscillations (13-30 Hz), and essential tremor coheres with oscillations of 8-27 Hz. Furthermore, evidence indicates that the optimal contacts for DBS programming can be predicted from the anatomic location of beta and gamma bands (48-200 Hz). Conclusion: LFP analysis has implications for improved electrode targeting and the development of a real-time, individualized, ‘closed-loop' stimulation system.

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“…Taking into account these facts from neurophysiology, it is likely that AOT may reorganize and sustain the normal loop circuits connecting the motor cortex with basal ganglia and these to motor cortex via thalamus [31]. It has been shown that action observation in PD patients is accompanied by changes in beta oscillatory activity of the subthalamic nucleus, similar to alpha and beta electroencephalography (EEG) desynchronization over the motor cortex, thus suggesting that basal ganglia may be engaged by the activity of the MNS [32]. Additionally, it is well known that PD patients improve their motor performances when externally cued [33].…”

Section: When Does Action Observation Treatment Work?mentioning

confidence: 99%

Action observation treatment: a novel tool in neurorehabilitation

Buccino

2014

Phil. Trans. R. Soc. B

276

203

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This review focuses on a novel rehabilitation approach known as action observation treatment (AOT). It is now a well-accepted notion in neurophysiology that the observation of actions performed by others activates in the perceiver the same neural structures responsible for the actual execution of those same actions. Areas endowed with this action observation-action execution matching mechanism are defined as the mirror neuron system. AOT exploits this neurophysiological mechanism for the recovery of motor impairment. During one typical session, patients observe a daily action and afterwards execute it in context. So far, this approach has been successfully applied in the rehabilitation of upper limb motor functions in chronic stroke patients, in motor recovery of Parkinson's disease patients, including those presenting with freezing of gait, and in children with cerebral palsy. Interestingly, this approach also improved lower limb motor functions in post-surgical orthopaedic patients. AOT is well grounded in basic neuroscience, thus representing a valid model of translational medicine in the field of neurorehabilitation. Moreover, the results concerning its effectiveness have been collected in randomized controlled studies, thus being an example of evidence-based clinical practice.

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Changes in subthalamic activity during movement observation in Parkinson’s disease: Is the mirror system mirrored in the basal ganglia?

Cited by 97 publications

References 53 publications

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

Clinical Implications of Local Field Potentials for Understanding and Treating Movement Disorders

Action observation treatment: a novel tool in neurorehabilitation

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