Changes in striatal dopamine release in stress-induced conditioned suppression of motility in rats

Katoh, Akira; Nabeshima, Toshitaka; Kuno, Ayako; Wada, Masako; Ukai, Reiko; Kameyama, Tsutomu

doi:10.1016/0166-4328(95)00228-6

Cited by 15 publications

(7 citation statements)

References 6 publications

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“…Dopamine utilization expressed as HVA/DA concentrations in nucleus accumbens is decreased in rats receiving chronic witness stress (Friedhoff et al 1995). Also in line with the present result is a recent finding that mental stress is associated with a reduction in extracellular DA release in the rat striatum (Katoh et al 1996). Friedhoff (1986Friedhoff ( , 1988 and Friedhoff et al (1995) have proposed the presence of a DA-dependent protective system in the brain that maintains mental stability in the face of biological or psychological insult.…”

Section: For Review)supporting

confidence: 78%

Effect of Mental Stress on Plasma Homovanillic Acid in Healthy Human Subjects

Sumiyoshi

Yotsutsuji

Kurachi

et al. 1998

Neuropsychopharmacology

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Section: For Review)supporting

confidence: 78%

Effect of Mental Stress on Plasma Homovanillic Acid in Healthy Human Subjects

Sumiyoshi

Yotsutsuji

Kurachi

et al. 1998

Neuropsychopharmacology

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“…Testing responses to aversive situations and contexts (domain negative valence system) in DAT mutant rats demonstrated the involvement of a subcortical hyperdopaminergic state in the expression of cue- and context-conditioned fear memory. Involvement of this system in fear conditioning was already demonstrated in earlier studies (Katoh et al, 1996; Martinez et al, 2008; Vucković et al, 2008). By contrast, behavior in a plus-maze test was not different between DAT mutant rats and their WT littermates.…”

Section: Discussionsupporting

confidence: 59%

Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene

Vengeliene

Bespalov

Roßmanith

et al. 2017

Disease Models &Amp; Mechanisms

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The research domain criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms. Here, we used a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) to systematically study the RDoC matrix. First, we examined the impact of the Slc6a3_N157K mutation on monoaminergic signaling. We then performed behavioral tests representing each of the five RDoC domains: negative and positive valence systems, cognitive, social and arousal/regulatory systems. The use of RDoC may be particularly helpful for drug development. We studied the effects of a novel pharmacological approach metabotropic glutamate receptor mGluR2/3 antagonism, in DAT mutants in a comparative way with standard medications. Loss of DAT functionality in mutant rats not only elevated subcortical extracellular dopamine concentration but also altered the balance of monoaminergic transmission. DAT mutant rats showed deficits in all five RDoC domains. Thus, mutant rats failed to show conditioned fear responses, were anhedonic, were unable to learn stimulus-reward associations, showed impaired cognition and social behavior, and were hyperactive. Hyperactivity in mutant rats was reduced by amphetamine and atomoxetine, which are well-established medications to reduce hyperactivity in humans. The mGluR2/3 antagonist LY341495 also normalized hyperactivity in DAT mutant rats without affecting extracellular dopamine levels. We systematically characterized an altered dopamine system within the context of the RDoC matrix and studied mGluR2/3 antagonism as a new pharmacological strategy to treat mental disorders with underlying subcortical dopaminergic hyperactivity.

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“…By temporally dissociating the onset of the cue and the extension of the lever, we also found that the increase in DA release seen during shock avoidance is to the cue, not the action. Importantly, increased DA release to cues predicting shock and reward do not appear to reflect salience, since cues that predict unavoidable shock—although salient—inhibit DA release73839. Taken together, these results suggest that increased DA release to cues predicting successful avoidance and reward-seeking report the predicted value associated with each.…”

Section: Discussionmentioning

confidence: 82%

Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance

2016

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Dopamine (DA) is critical for reward processing, but significantly less is known about its role in punishment avoidance. Using a combined approach-avoidance task, we measured phasic DA release in the nucleus accumbens (NAc) of rats during presentation of cues that predicted reward, punishment or neutral outcomes and investigated individual differences based on avoidance performance. Here we show that DA release within a single microenvironment is higher for reward and avoidance cues compared with neutral cues and positively correlated with poor avoidance behaviour. We found that DA release delineates trial-type during sessions with good avoidance but is non-selective during poor avoidance, with high release correlating with poor performance. These data demonstrate that phasic DA is released during cued approach and avoidance within the same microenvironment and abnormal processing of value signals is correlated with poor performance.

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Changes in striatal dopamine release in stress-induced conditioned suppression of motility in rats

Cited by 15 publications

References 6 publications

Effect of Mental Stress on Plasma Homovanillic Acid in Healthy Human Subjects

Effect of Mental Stress on Plasma Homovanillic Acid in Healthy Human Subjects

Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene

Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance

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