Changes in Strain-Specific Urine Odors of Mice due to Bone Marrow Transplantations

Eggert, Frank; Luszyk, Dagmar; Ferstl, Roman; Müller-Ruchholtz, W

doi:10.1159/000118592

Cited by 6 publications

(6 citation statements)

References 6 publications

(9 reference statements)

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“…The results were confirmed in another experimental paradigm and similar results were found in semiallogeneic reconstituted rats [ 13]. Since in these stud ies [12,13] the animals used as donors and recipients dif fer genetically not only in the H-2, but also in their genetic backgrounds, influences of genetic loci other than the H-2 upon the odors under examination could not been ruled out.…”

Section: Introductionsupporting

confidence: 70%

“…The expression of genetically determined urinary che mosignals via the hematopoietic system has been docu mented in a number of studies that reveal a change in uri nary odors after experimental bone marrow transplanta tions between genetically different inbred strains of mice [10,12,13], Up to now the only group of genes which has been identified to be expressed via the hematopoietic system is the MHC. The present study confirms that MHC-associated odors are expressed via the hematopoietic system.…”

Section: Discussionmentioning

confidence: 99%

“…By using a technique to prevent graft-versus-host dis ease [ 11 ] we were able to examine systematically a change in urine odor after experimental bone marrow transplan tations in mice [12]. The results of these experiments con firmed that the hematopoietic system influences odor specificity.…”

Section: Introductionmentioning

confidence: 99%

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MHC-Associated and MHC-lndependent Urinary Chemosignals in Mice Are Expressed via the Hematopoietic System

Eggert¹,

Uharek

Müller-Ruchholtz

et al. 1994

Neuropsychobiology

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The change in genetically determined urine odors which appears after experimental bone marrow transplantations in mice was examined in order to test whether the HMC is the only group of genes that influences the chemosensory identity via the hematopoietic system. 5 female rats were trained in a computer-controlled olfactometer to discriminate urine odors of two MHC congenic or background congenic inbred strains of mice. Transfer-of-training tests with urine samples of irradiated mice which were restored with bone marrow either from an MHC congenic or a background congenic inbred strain reveal a change of urinary chemosignals after both types of experimental bone marrow transplantation. Thus, both MHC-associated as well as MHC-independent urinary chemosignals are expressed via the hematopoietic system.

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Section: Introductionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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MHC-Associated and MHC-lndependent Urinary Chemosignals in Mice Are Expressed via the Hematopoietic System

Eggert¹,

Uharek

Müller-Ruchholtz

et al. 1994

Neuropsychobiology

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“…A change in urine odor after allogeneic bone marrow transplantations in mice was systematically examined [5]. The results con firm the findings that the hematopoietic system in fluences odor specificity.…”

Section: Introductionmentioning

confidence: 59%

The Hematopoietic System Influences Odor Specificity in Mice and Rats

Eggert¹,

Uharek

Müller-Ruchholtz

et al. 1993

Neuropsychobiology

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The change in strain-specific urine odors which appears after bone marrow transplantations was examined in mice and rats in order to demonstrate an influence of the hematopoietic system on urinary chemosignals. Four rats were trained in an olfactometer to discriminate two allogeneic mouse or rat strains via their urine odors. Urine samples obtained from two inbred strains of mice, from two inbred strains of rats, from allogeneic reconstituted mice, and from semiallogeneic reconstituted rats were combined in a number of ‘transfer of training’ tests. Results confirm findings that the hematopoietic system influences odor specificity in mice. For the first time a change of urinary chemosignals after bone marrow transplantation in rats was demonstrated by using semiallogeneic reconstituted rat chimeras.

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“…Studies over the last 30 years show that, through odor, mice express information about age, sex, genetic background (Arakawa, Arakawa, Blanchard, & Blanchard, 2007; Eggert, Luszyk, Ferstl, & Muller-Ruchholtz, 1989), degree of kinship (Gilder & Slater, 1978) and parasitic infection (Kavaliers, Choleris, & Pfaff, 2005; Kavaliers & Colwell, 1995). Scent marking behaviors are also highly dependent upon social context (Arakawa, et al, 2007).…”

Section: Section 3: Translationmentioning

confidence: 99%

The autism diagnosis in translation: shared affect in children and mouse models of ASD

Bishop

Lahvis

2011

Autism Research

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In recent years, there have been significant improvements in assessment and diagnostic procedures for autism spectrum disorders (ASD). Standardized diagnostic instruments have been developed, promoting consistent diagnostic practices among clinicians. For clinical researchers, these instruments have facilitated collaborations across different sites by providing standardized metrics with which to evaluate ASD symptoms. Nevertheless, because ASD remains a diagnosis that is defined on the basis of behavior, there are significant challenges associated with modeling ASD social behaviors in laboratory animals. In order to more effectively study the causes of ASD symptoms and behaviors, there is a need to develop new ways of measuring social behaviors that can be applied to non-human species. Critically, while verbal dialogue between the clinician and patient is integral to clinical diagnoses, it cannot be employed for studies of animal models. However, observations of autistic-like social interactions can be modeled in animals. In this regard, communication between professionals in the clinical and basic sciences is necessary to break down the complex diagnosis into units of social impairment that can be more feasibly measured in different species. This paper presents a discussion between an animal researcher and a clinical psychologist. Using shared affect as an example, we explore potential avenues for increasing the utility of animal models to move us toward a better understanding of the mechanisms underlying social impairments in ASD. In the absence of molecular biomarkers that can be used to diagnose ASD, current diagnostic tools depend upon clinical assessments of behavior. Research efforts with human subjects have successfully utilized standardized diagnostic instruments, which include clinician interviews with parents and direct observation of the children themselves (Risi et al., 2006). However, because clinical instruments are semi-structured and rely heavily on dynamic social processes and clinical skill, scores from these measures do not necessarily lend themselves directly to experimental investigations into the causes of ASD. Studies of the neurobiology of autism require experimental animal models. Mice are particularly useful, in this regard, for elucidating genetic and toxicologjcal contributions to impairments in social function (Halladay et al., 2009). Behavioral tests have been developed that are relevant to autism (Crawley, 2004, 2007), including measures of repetitive behaviors (Lewis, Tanimura, Lee, & Bodfish, 2007; Moy et al., 2008), social behavior (Brodkin, 2007; Lijam et al., 1997; Moretti, Bouwknecht, Teague, Paylor, & Zoghbi, 2005), and vocal communication (Panksepp et al., 2007). Advances also include development of high-throughput measures of mouse sociability that can be used to reliably compare inbred mouse strains (Moy, et al., 2008; Nadler et al., 2004), as well as measures of social reward (Panksepp & Lahvis, 2007) and empathy (Chen, Panksepp, & Lahvis, 2009; Langford et al., 2006). ...

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Changes in Strain-Specific Urine Odors of Mice due to Bone Marrow Transplantations

Cited by 6 publications

References 6 publications

MHC-Associated and MHC-lndependent Urinary Chemosignals in Mice Are Expressed via the Hematopoietic System

MHC-Associated and MHC-lndependent Urinary Chemosignals in Mice Are Expressed via the Hematopoietic System

The Hematopoietic System Influences Odor Specificity in Mice and Rats

The autism diagnosis in translation: shared affect in children and mouse models of ASD

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