Changes in some liver lipids of non-diabetic and diabetic rats following administration of combined extracts of Vernonia amygdalina and Azadirachta indica

Abstract

Some lipid fractions of whole liver homogenate (WLH) of normal and streptozotocin diabetic rats administered combined extracts of Vernonia amygdalina (VA) and Azadirachta indica (AI) for 28 days were evaluated. There was significant decrease (p<0.05) in HDL-cholesterol concentration in hepatocytes of diabetic control rats compared to the normal control. Whereas administration of single extracts of VA or AI further reduced the HDL-cholesterol non-significantly (p>0.05) and significantly (p<0.05), respectively, co-administration of the two extracts significantly increased (p<0.05) the HDL-cholesterol to levels comparable to the insulin treated group. Total cholesterol (TC) concentration of diabetic rats was not significantly altered by the extracts. In the non diabetic counterparts, AI extract alone, caused a significant elevation (p<0.05) of TC concentration. However, this effect was modulated by VA extract when given as combined extract. Triacylglycerol (TG) and very low density lipoprotein (VLDL) cholesterol levels in hepatocytes of diabetic control rats which reduced significantly (p<0.05) following diabetes induction, became significantly increased (p<0.05) upon administration of both single and combined extracts. The effect of extracts on these latter indices was better than insulin treated group. Combined extract of VA and AI suppresses hyperlipidemia of diabetes via hepatic lipid modulation and may be better in this respect than insulin.

The Effect of Gongronema latifolium Leaf Extract on Blood Biochemical Assay in Diabetic Rats

“…Diabetes induction with STZ is observed to be associated with increased serum enzyme activities [30]. Hence the elevated levels of the enzymes in DC; ALT and AST generally, was attributed to injury caused to the hepatocydtes by streptozotocin which now affects the normal functions of the liver, since these enzymes are indisputably, markers of liver injury as stated earlier, they are localized in the cytoplasm under normal conditions and are released into the circulation under abnormal conditions (e.g.…”

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

“…However, a report indicated that the extract could trigger hyponatremia in rats (89). It was further confirmed that other selected plant extracts co-administered with the V. amygdalina extract reversed hyponatremia but exacerbated hypophosphatemia, which was diabetes-induced (140). In aspirin-triggered gastric ulcers in rats, leaf extract was observed to induce gastroprotection and prevent renal damage (141,142).…”