Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Yousri, R. M.; Roushdy, H.M.; Gawish, M. A. M.

doi:10.1080/10256019108622485

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…The results of the present study showed that wholebody gamma irradiation (6 Gy) induced hyperlipidaemia particularly on the first and third days post-treatment. These data confirm previous reports that the lethal dose of ionizing radiation induces hyperlipidemia [1,23], with inhibition of lipoprotein lipase in experimental rabbits [24]. Cremophor administration before irradiation restored normal lipid-level profiles.…”

Section: Discussionsupporting

confidence: 91%

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Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Ramadan

Shouman

Sayed‐Ahmed

et al. 2001

Pharmacological Research

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Section: Discussionsupporting

confidence: 91%

“…Serious problems are generally encountered after acute exposure to high doses of radiation [1]. It has been reported that radiation could induce hyperlipidaemia with elevation of triglycerides concentration in the blood [1,2]. It was also reported that ionizing radiation affected liver and kidney functions [3,4].…”

Section: Introductionmentioning

confidence: 99%

Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Ramadan

Shouman

Sayed‐Ahmed

et al. 2001

Pharmacological Research

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“…Several biological parameters of animal plasma including cholesterol, phospholipids and so on have been extensively investigated. The changes in cholesterol, phospholipids and triglyceride fractions in the plasma of rabbits and rats after irradiation had been published (Feurgard et al, 1998;Di Luzio and Simon, 1957;Rizvi et al, 1984;Feliste et al, 1981;Yousri et al, 1991). However, studies on plasma phospholipid species profiling alterations and biomarkers of irradiated rats have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–mass spectrometry technique

Wang

Yang

Nie

2009

Biomedical Chromatography

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Lipidomics, a prominent area of metabolomics, utilizes novel analytical methodologies to study the extensive classes of lipid molecules, changes in lipid metabolism and lipid-mediated signaling processes. In this paper, the phospholipid metabolic profiles changes and potential biomarker identification in the rats plasma after gamma-irradiation exposure were investigated by coupling high performance liquid chromatography-mass spectrometry technology to multivariate statistical analysis. Orthogonal partial least-squares to latent structures discriminate analysis (OPLS-DA) was used to find the potential plasma phospholipids biomarkers of rats for radiation exposure. According to the corresponding tandem mass spectrometric results, potential biomarkers were identified. After exposure to gamma-rays, phosphatidylethanolamine and phosphatidylserine showed a marked increase, and phosphatidylcholine, sphingomyelin and lysophosphatidylcholine followed the same trend, although their rise was not significant. The results suggested that radiated rats had a phospholipid metabolic abnormality, which could be an alternative way to assess the radiaton exposure. The biomarkers may involve a radiation-induced apoptosis pathway and represent a promising target for discovery new radioprotective drugs and radiosensitizers.

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“…Serious problems are generally encountered after acute exposure to high doses of ionizing radiations (Yousri et al, 1991). Ionizing radiations interact with biological systems through free radicals generated by water radiolysis.…”

Section: Introductionmentioning

confidence: 99%

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

Abdelhalim¹,

Moussa²

2013

Afr. J. Pharm. Pharmacol.

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This study aimed to address the different gamma radiations doses effect on the liver and kidney function of rats: in vivo. A total of 60 healthy male Wistar-Kyoto rats were whole body gamma irradiated with Co 60 source with 0.883 cG/sec dose rate at the beginning of the experiment. The rats were randomly divided into 4 gamma-irradiation groups (25, 50, 75 and 100 Gy) The serum levels of activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), UREA, creatinine (CREA) and uric acid (UAC) were measured using automated biochemical analyzer. The ALT, GGT, ALP values significantly decreased with the different gamma radiation doses compared with the control. The AST and UREA values significantly decreased after irradiation with 25 and 50 Gy gamma radiation doses compared with the control while it significantly increased with 75 and 100 Gy gamma radiation doses. The levels of CREA values decreased with no significant manner after the irradiation with gamma radiation doses compared with the control. The levels of UAC values significantly increased with 50, 75 and 100 Gy gamma radiation doses. The serum ALT and AST levels are common markers for hepatic toxicity: A lower amount of ALP indicates liver problems. The decreased CREA and the increased UAC levels might indicate development of nephritis and renal dysfunction. The excess UAC might be converted to crystals depositing in the tiny tubes of the kidney and causing acute kidney damage. It is proposed that oxidative stress is linked to the organ damage following exposure to ionizing radiation, and after the onset of oxidative stress, antioxidant treatment should be applied to delay or prevent the progression of damage.

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Changes in Some Blood Lipid Fractions in Whole Body Irradiated Rats as Influenced by some Radioprotectors

Cited by 6 publications

References 31 publications

Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography–mass spectrometry technique

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

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