The significance of social and economic inequality becomes more prominent due to the lack of regional planning, a phenomenon present in third world countries, where good governance is a rare administrative reality. Coupled with this is the lacuna of administrative coordination, which exacerbates the inequality scenario. The paper highlights the significant factors responsible for social and economic inequality in Sindh, a province of Pakistan. The lopsided nature of urban development, coupled with rural backwardness, acts as a double-edged knife leading to exaggeration of socioeconomic inequalities caused mainly by population explosion natural in rural areas and migratory in urban areas. This leads to staggering economic conditions, with falling income levels, perpetrating vicious social and cultural impacts. Reduction of inequalities demands implementation of planned, targeted development strategies in line with the policies of regional planning.