Changes in sleepiness and 24-h blood pressure following 4 months of CPAP treatment are not mediated by ICAM-1

Pak, Victoria M.; Maislin, David; Keenan, Brendan T.; Townsend, Raymond R.; Benediktsdóttir, Bryndís; Dunbar, Sandra B.; Gíslason, Þórarinn; Kuna, Samuel T.

doi:10.1007/s11325-020-02257-0

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…ICAM-1, E-selectin, and VCAM-1 decreased after CPAP treatment in several studies [5,10,23]. However, interestingly, some studies reported an increase in CAMs levels [9,16]. In our meta-analysis, the combined results confirmed that the circulating ICAM-1 and E-selectin levels were decreased in patients with OSA after CPAP treatment, but this was not the case for VCAM-1 levels, indicating that CPAP therapy could reduce inflammatory responses in OSA patients.…”

Section: Discussionmentioning

confidence: 98%

“…1), 11 articles were finally included. Each study investigated one or more CAMs markers: 10 studies on ICAM-1 [5,9,10,[16][17][18][19][20][21][22], 5 on E-selectin [5,17,19,21,23], and 5 on VCAM-1 [5,16,19,21,23]. The characteristics of included studies for different CAMs markers are provided in Table 1.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…It has been shown to reduce the risk of cardiovascular events and the levels of circulating ICAM-1, VCAM-1, and E-selectin in OSA patients, but the results have been controversial. For example, the study by Pak et al showed that in OSA patients, four months of CPAP treatment with good adherence did not reduce ICAM-1 levels [9]. However, another study showed a significant reduction in ICAM-1 levels during a 6-8-week period of CPAP treatment [10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Continuous Positive Airway Pressure on Cell Adhesion Molecules in Patients with Obstructive Sleep Apnea: A Meta-Analysis

Tian

Xiao

Kang

et al. 2021

Lung

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Purpose Previous studies have confirmed that patients with obstructive sleep apnea (OSA) have higher systemic inflammatory markers, including intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and E-selectin compared to control subjects. However, the effects of continuous positive airway pressure (CPAP) therapy on circulating levels of ICAM-1, VCAM-1, and E-selectin in OSA patients remain inconsistent. Therefore, the primary purpose of the present meta-analysis is to estimate the effect of CPAP therapy on these cell adhesion molecules (CAMs) in patients with OSA. Methods The PubMed, Scopus, Embase, and Cochrane Library databases were searched. The overall effects were measured by the standardized mean difference (SMD) with a 95% confidence interval (CI). A random effects model or a fixed-effects model was used, depending on the heterogeneity of the studies. Results A total of 11 studies were included, comprising 650 OSA patients. The pooled results showed that CPAP therapy significantly decreased ICAM-1 (SMD = − 0.283, 95% CI − 0.464 to − 0.101, p = 0.002) and E-selectin levels (SMD = − 0.349, 95% CI − 0.566 to − 0.133, p = 0.002). In contrast, there was no significant improvement of VCAM-1 levels after CPAP treatment (SMD = − 0.160, 95% CI − 0.641 to 0.320, p = 0.513). Conclusions Our meta-analysis demonstrated that CPAP treatment significantly decreased the circulating levels of ICAM-1 and E-selectin in OSA patients. Thus, ICAM-1 and E-selectin may be effective markers to evaluate CPAP therapy for reducing OSA cardiovascular risk in clinical practice.

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Section: Discussionmentioning

confidence: 98%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Continuous Positive Airway Pressure on Cell Adhesion Molecules in Patients with Obstructive Sleep Apnea: A Meta-Analysis

Tian

Xiao

Kang

et al. 2021

Lung

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show abstract

“…We analyzed data from the Penn Iceland Sleep Apnea (PISA; NCT03176732) cohort and examined HOMA-IR at baseline and 4 months in obese and non-obese participants adherent to CPAP and who did not self-report as having diabetes and were not prescribed insulin or any oral hypoglycemic agent. PISA was an observational study in adults with OSA adherent to CPAP; details of this study have been previously reported 3,4 .…”

Section: To the Editormentioning

confidence: 99%

Obesity does not modify the effect of continuous positive airway pressure on insulin resistance in adults with obstructive sleep apnoea

Pak

Maislin²,

Keenan³

et al. 2023

ERJ Open Res

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Nocturnal blood pressure and nocturnal blood pressure fluctuations: the effect of short-term CPAP therapy and their association with the severity of obstructive sleep apnea

Picard

Panagiotidou

Tammen

et al. 2022

Journal of Clinical Sleep Medicine

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Changes in sleepiness and 24-h blood pressure following 4 months of CPAP treatment are not mediated by ICAM-1

Cited by 3 publications

References 31 publications

Effects of Continuous Positive Airway Pressure on Cell Adhesion Molecules in Patients with Obstructive Sleep Apnea: A Meta-Analysis

Effects of Continuous Positive Airway Pressure on Cell Adhesion Molecules in Patients with Obstructive Sleep Apnea: A Meta-Analysis

Obesity does not modify the effect of continuous positive airway pressure on insulin resistance in adults with obstructive sleep apnoea

Nocturnal blood pressure and nocturnal blood pressure fluctuations: the effect of short-term CPAP therapy and their association with the severity of obstructive sleep apnea

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