Changes in skeletal muscle cellularity in starved and refed young rats

Hegarty, P. V. J.; Kim, K. O.

doi:10.1079/bjn19800019

Cited by 21 publications

(22 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1979] human [Cheek et al. 1970;Hansen-Smith et al, 1979;Montgomery, 1962] and rats [Hegarty and Kim, 1980;Layman et al, 1981]. This is, however, different from the observations of Rowe [1968] who even though he observed decrease in fibre diameter of the white fast muscles in starved mice did not observe any in the slow soleus muscle.…”

Section: Discussioncontrasting

confidence: 56%

“…The smaller number of muscle fibres present in the protein-malnourished mice cannot be as a result of all the muscle fibres not being counted as has been sug gested by Parsons et al [1982] to be responsible for the smaller number of muscle fibres observed in starved rats by Hegarty and Kim [1980] and Layman et al [1981] who employed the indirect method of fibre estimation of Thompson et al [1979). Rayne and Crawford [ 1975] stated that the best way to determine the number of muscle fibres is to choose a muscle small enough that cross-section through its midbelly will include all the fibres which can be counted directly.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fibre Number and Sizes of Mouse Soleus Muscle in Early Postnatal Protein Malnutrition

Ihemelandu¹

1985

Cells Tissues Organs

View full text Add to dashboard Cite

The effect of early postnatal protein malnutrition on the development of soleus muscle was investigated in 26 mice (13 males, 13 females). The control group received a balanced diet containing 18% lactalbumin while the protein-malnourished group received protein deficient diet containing 0.5% lactalbumin. The body weight was determined both at 3 weeks (weaning age) and 12 weeks of age. The soleus muscle weight, total number and sizes of muscle fibres were also determined at 12 weeks of age for each mouse. There was considerable retardation of body weight and soleus muscle weight. The smaller soleus muscle mass of protein-malnourished mice resulted from loss of muscle fibres and hypotrophy of the remaining fibres. Permanent retardation of body weight after recovery from early postnatal protein malnutrition may be as a result of loss of muscle fibres during that period.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Fibre Number and Sizes of Mouse Soleus Muscle in Early Postnatal Protein Malnutrition

Ihemelandu¹

1985

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Soleus fiber diameters for the three restricted groups at 100 days were only slightly smaller. Hegarty and Kim (9) reported that refeeding after a 3-day starvation prompted complete recovery of muscle fiber diameter, but their restriction caused a rapid loss of body weight whereas the animals of the present study …”

Section: Resultscontrasting

confidence: 36%

Cellular Development of Skeletal Muscle during Early Periods of Nutritional Restriction and Subsequent Rehabilitation

Glore

Layman

1983

Pediatr Res

View full text Add to dashboard Cite

SummarvDietary restrictions that occur shortly after birth reduce body growth &d proliferation of muscle nuciei (16,31), but the effects This study was designed to examine the effects of periods on skeletal muscle fiber number remain equivocal (1, 2, 8, 9, 10, of nutritional restrictions on the cellular growth potential of 13,16,18,24,26). Rowe (24) and strickland (26) reported skeletal muscle. Skeletal muscle growth and cell development of that early food on mice and pigs, respectively, did not Sprague-Dawley rats were examined at 25 and days of alter fiber number. Hegarty and Kim (10) and Layman et al. (13) age in controls (c) and three treatment groups. Each of the three found a decrease in fiber number in hamsters and rats after total treatments consisted of a 50% restriction of food intake for 21 and reported a lower number of days through @station (GR), lactation (LR), and an muscle fibers in infants who died from protein-energy malnutripostweanling period (PWR, of age). At the tion versus infants who died in accidents. Recovey of of the restricti0ns, body weights of the GR, LR, and PWR groups human infants from undernutrition has been reported to involve were 85, 42, and 59% of the weights of their age both hyperplasia and hypertrophy (2'4, but this was based Rehabilitation to 100 days of age enabled the GR, LR, and PWR solely on biochemical data and not on direct measurement of groups achieve, 93, 86, and 93% the muscle fiber number and size. The accumulation of muscle DNA group body weight. At 25 and days of age, weights, represents a biochemical aspect of growth but does not directly number, mean fiber diameter, DNA 'Ontent, and reflect changes in the cellular unit of skeletal muscle. The present protein content were determined in the soleus and extensor digi-study examines changes in both nuclear number ( D N~) and torum longus (EDL) muscles. Soleus and EDL muscle weights, muscle fiber number during growth and chronic DNA 'Ontents, and protein from the GR and LR groups tional restriction and after subsequent rehabilitation to determine were significantly less than C group values at 25 days, and the LR their relative influences on skeletal muscle growth. group values were significantly less than those from the GR group. When expressed as % of control values at 100 days, muscle weights and DNA contents were respectively: GR soleus 91%, 92%; GR IN). Each animal muscle fiber numbers were unchanged by the gestational, lacta-was individually housed in a wire-bottomed cage and maintained tional, and postweanling restrictions at both 25 and 100 days; i, a facility with controlled temperature (22-23OC) and a 12-h however, an age-related decrease in fiber number 0c~ufled in both light-dark cycle. All rats received tap water ad libitum. The female muscles for all groups. Reduction in muscle weights resulted from rats were fed purina Lab chow during an initial 4-day acclimation changes in muscle fiber size rather than fiber number. The ability period. The standard purified diet was introduced on the fifth da...

show abstract

“…Later undernutrition may not cause such permanent deficit, since the number of muscle fibers is already fixed early in life (3,4) and is not changed thereafter. However, a decrease in the number of muscle fibers was observed during starvation which caused a 35-45% loss of body weight in postweaning and young rats (5). Exercise induced increases in muscle fiber number in cat (6).…”

mentioning

confidence: 99%

“…They also found that undernutrition before weaning caused significant and permanent deficit in total fiber number. Even after weaning, starvation could cause a decrease in muscle fibers (5,15). Thus, dietary protein or energy restriction alone would not affect muscle fiber number.…”

mentioning

confidence: 99%

The Morphological and Biochemical Changes in Skeletal Muscle Fibers by Dietary Protein Restriction.

Tanaka

Hayakawa

Zyo

et al. 1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe effects of dietary protein restriction on skeletal mus cle fibers were studied according to morphological and biochemical ap proaches. Protein and DNA content of quadriceps muscles from young adult rats were decreased by the low protein and protein-free diet. Morphological examination demonstrated that there was a significant decrease in the size of muscle fibers without change in their numbers due to protein restriction. The protein/DNA ratio, accepted as an index of cell size in biochemical approaches, was compared with cell size on photo micrographs. Actual fiber size appeared much smaller than that indicated by the protein/DNA ratio.

show abstract

Changes in skeletal muscle cellularity in starved and refed young rats

Cited by 21 publications

References 14 publications

Fibre Number and Sizes of Mouse Soleus Muscle in Early Postnatal Protein Malnutrition

Fibre Number and Sizes of Mouse Soleus Muscle in Early Postnatal Protein Malnutrition

Cellular Development of Skeletal Muscle during Early Periods of Nutritional Restriction and Subsequent Rehabilitation

The Morphological and Biochemical Changes in Skeletal Muscle Fibers by Dietary Protein Restriction.

Contact Info

Product

Resources

About