Changes in silver nanoparticles exposed to human synthetic stomach fluid: Effects of particle size and surface chemistry

Mwilu, Samuel K.; Badawy, Amro M. El; Bradham, Karen D.; Nelson, Clay; Thomas, David J.; Scheckel, Kirk G.; Tolaymat, Thabet; Ma, Liang; Rogers, Kim R.

doi:10.1016/j.scitotenv.2012.12.036

Cited by 107 publications

(107 citation statements)

References 20 publications

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“…The aggregation of Ag and TiO 2 NPs was also observed in the same culture medium by NTA in a study of NPs added to paints [109]. Similarly, changes in size of Ag NPs exposed to synthetic human stomach fluid have also been studied by NTA [103]. In relation with environmental studies, Piccapietra et al [110] studied the colloidal stability of carbonate coated silver nanoparticles in synthetic media and natural freshwaters at different concentration levels of NPs.…”

Section: Light Scattering Techniquesmentioning

confidence: 94%

“…Although DLS has serious limitations for sizing nanoparticle suspensions in complex matrices, it is very valuable to monitor aggregation behaviours. For example, aggregation of Ag NPs exposed to human synthetic stomach fluid [103], gastric juices [104] or river water [105] has been studied by DLS. In addition, this technique has also been used to proof the reliability of AF4 data in consumer products, although some results were biased to larger particle diameters respect to AF4 results [106].…”

Section: Light Scattering Techniquesmentioning

confidence: 99%

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Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Laborda

Bolea

Cepriá

et al. 2016

Analytica Chimica Acta

322

170

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The increasing demand of analytical information related to inorganic engineered nanomaterials requires the adaptation of existing techniques and methods, or the development of new ones.The challenge for the analytical sciences has been to consider the nanoparticles as a new sort of analytes, involving both chemical (composition, mass and number concentration) and physical information (e.g. size, shape, aggregation). Moreover, information about the species derived from the nanoparticles themselves and their transformations must also be supplied. Whereas techniques commonly used for nanoparticle characterization, such as light scattering techniques, show serious limitations when applied to complex samples, other well-established techniques, like electron microscopy and atomic spectrometry, can provide useful information in most cases. Furthermore, separation techniques, including flow field flow fractionation, capillary electrophoresis and hydrodynamic chromatography, are moving to the nano domain, mostly hyphenated to inductively coupled plasma mass spectrometry as element specific detector.Emerging techniques based on the detection of single nanoparticles by using ICP-MS, but also coulometry, are in their way to gain a position. Chemical sensors selective to nanoparticles are in their early stages, but they are very promising considering their portability and simplicity.Although the field is in continuous evolution, at this moment it is moving from proofs-of-2 concept in simple matrices to methods dealing with matrices of higher complexity and relevant analyte concentrations. To achieve this goal, sample preparation methods are essential to manage such complex situations. Apart from size fractionation methods, matrix digestion, extraction and concentration methods capable of preserving the nature of the nanoparticles are being developed. This review presents and discusses the state-of-the-art analytical techniques and sample preparation methods suitable for dealing with complex samples. Single-and multimethod approaches applied to solve the nanometrological challenges posed by a variety of stakeholders are also presented.

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Section: Light Scattering Techniquesmentioning

confidence: 94%

Section: Light Scattering Techniquesmentioning

confidence: 99%

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Laborda

Bolea

Cepriá

et al. 2016

Analytica Chimica Acta

322

170

View full text Add to dashboard Cite

show abstract

“…This type of assay has also been used to determine how gastric conditions impact the behavior of NMs. Silver NPs in simulated gastric fluid agglomerated significantly and released ionic silver from their surface that re-precipitated and coated the agglomerates as insoluble silver chloride (Mwilu et al, 2013). Interestingly, the digestion of pure silver ions also resulted in the de novo formation of silver chloride agglomerates ranging in size from 1 micron to greater than 10 microns, with 50 nm particles visible on the surface by electron microscopy energy dispersive X-ray spectroscopy.…”

Section: In Vitro Non-cellular Fluid Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

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“…Several separation and purification methods have been explored in the last years for the characterization of nanostructures after ingestion, passage through GI systems and once incorporated in human fluids. Inorganic nanostructures (e.g., gold and silver) and others from synthetic materials have been the most studied [4,111]. However, few works de-scribe methodologies and useful techniques for separation and purification of bio-based nanostructures.…”

Section: Separation Purification and Characterization Of Bio-based Nmentioning

confidence: 99%

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

et al. 2015

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The development of bio-based nanostructures as nanocarriers of bioactive compounds to specific body sites has been presented as a hot topic in food, pharmaceutical and nanotechnology fields. Food and pharmaceutical industries seek to explore the huge potential of these nanostructures, once they can be entirely composed of biocompatible and non-toxic materials. At the same time, they allow the incorporation of lipophilic and hydrophilic bioactive compounds protecting them against degradation, maintaining its active and functional performance. Nevertheless, the physicochemical properties of such structures (e.g., size and charge) could change significantly their behavior in the gastrointestinal (GI) tract. The main challenges in the development of these nanostructures are the proper characterization and understanding of the processes occurring at their surface, when in contact with living systems. This is crucial to 2 understand their delivery and absorption behavior as well as to recognize potential toxicological effects. This review will provide an insight into the recent innovations and challenges in the field of delivery via GI tract using bio-based nanostructures. Also, an overview of the approaches followed to ensure an effective deliver (e.g., avoiding physiological barriers) and to enhance stability and absorptive intestinal uptake of bioactive compounds will be provided. Information about nanostructures' potential toxicity and a concise description of the in vitro and in vivo toxicity studies will also be given.

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Changes in silver nanoparticles exposed to human synthetic stomach fluid: Effects of particle size and surface chemistry

Cited by 107 publications

References 20 publications

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Detection, characterization and quantification of inorganic engineered nanomaterials: A review of techniques and methodological approaches for the analysis of complex samples

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

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