Changes in serum prolactin level during intracytoplasmic sperm injection, and effect on clinical pregnancy rate: a prospective observational study

Abstract

BackgroundTransient hyperprolactinemia was proven to adversely affect the outcome of IVF. We aimed to identify changes in serum prolactin levels in patients undergoing ICSI, and to evaluate the effect of these changes on the clinical pregnancy rate.MethodsA prospective observational study included 90 patients scheduled for ICSI cycles. In each case 4 serum samples were collected during the cycle (midluteal, before ovum pick up procedure (OPU), 2 h after OPU, and before embryo transfer). Serum prolactin level was determined by immunoassay each time.ResultsThe sample collected 2 h after OPU had a mean difference of 25.8 ± 2.8 ng/ml compared to the basal serum prolactin (p < 0.01). In comparison to other samples, this highlighted a significant hyperprolactinemia occurring after OPU, and resolving before embryo transfer. No statistically significant difference between the different serum prolactin samples amongst the pregnant and non pregnant patients. There was a significant positive pearson correlation between the prolactin levels before OPU, and the presence of higher quality embryos (r = 0.274, p = 0.019).ConclusionIn normoprolactinemic women transient hyperprolactinemia is identified in patients undergoing ICSI, and it doesn’t affect the clinical pregnancy rates. A positive correlation was identified between higher quality embryos, and serum prolactin level before OPU.Trial registrationClinicalTrials.gov Identifier: NCT02292953, First received: November 10, 2014.

Roles of estradiol levels on the day of human chorionic gonadotrophin administration in the live birth of patients with frozen embryo transfer

“…Previous studies showed that the alterations of these hormones such as basal LH, basal PRL, and basal P levels were associated with pregnancy in embryo transfer 37‐39 . In our study, there were no statistical differences in the levels of basal LH, basal PRL, and basal P between the live‐birth group and the no‐live‐birth group.…”

Homocysteine Level Related To Age Is Associated With Embryo Quality In IVF Women With Diminished Ovarian Reserve

“…[27,28]. In hence, some researchers do not believe it might affect the outcome of IVF [29]. Hcy, a sulfur-containing non-essential amino acid generated from the metabolism of the methionine and cysteine, plays a vital role in remethylation and trans-sulphuration.…”

Factors affecting Embryo Quality and Pregnancy Outcome in Intra-Cytoplasmic Sperm Injection using Decapeptyl and Cetrorelix- A retrospective study

“…Studies have shown similar results, where higher prolactin levels have led to better quality embryos being retrieved, along with higher pregnancy rates. 22 However, some studies have also shown no correlation between prolactin and the success of the treatments 23 Prolactin receptors and its mRNA are present in mature oocytes, and have shown to play a role in oocyte maturation. 23 Also, prolactin receptors have been found on the endometrium.…”

“…They increase the endometrium's receptivity and enhances blastocyst implantation during artificial implantation. 22 Furthermore, estradiol levels have been shown to have a positive impact on embryo and pregnancy outcomes in previous studies 24 Estradiol has proved to slow the pace of follicular development and hence improve follicular synchronization. 24,25 This could explain why embryo quality is improved by higher levels of estradiol.…”