Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma

Chen, Chuen‐Fei; Lee, Wen‐Chung; Yang, Hwai I.; Chang, H. C.; Jen, C.-L.; Iloeje, Uchenna H.; Su, Jun; Hsiao, Chuhsing Kate; Wang, Li–Yu; You, San–Lin; Lu, Sheng–Nan; Chen, Chien‐Jen

doi:10.1053/j.gastro.2011.06.036

Cited by 235 publications

(195 citation statements)

References 33 publications

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“…Adapted from data in Fattovich et al (2008), McMahon (2009), El-Serag (2012), and Trépo et al (2014). Elevated baseline serum HBV DNA has been shown to be associated with subsequent development of cirrhosis ) and HCC ); more recent evidence involving repeated measurement during follow-up has further shown that the long-term persistence of high-HBV DNA levels predicts HCC risk (Chen et al 2011), and that the association increases along a gradient of viral load. A similar relationship was shown with alanine aminotransferase (ALT) level (Chen et al 2011).…”

Section: Natural History Infection and Immunitymentioning

confidence: 99%

“…Elevated baseline serum HBV DNA has been shown to be associated with subsequent development of cirrhosis ) and HCC ); more recent evidence involving repeated measurement during follow-up has further shown that the long-term persistence of high-HBV DNA levels predicts HCC risk (Chen et al 2011), and that the association increases along a gradient of viral load. A similar relationship was shown with alanine aminotransferase (ALT) level (Chen et al 2011). Further study is needed to determine whether these associations are replicated in other populations, as these studies have most commonly been conducted in individuals of Asian background, and largely those with hepatitis B genotype B or C.…”

Section: Natural History Infection and Immunitymentioning

confidence: 99%

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Hepatitis B Virus Epidemiology

MacLachlan

Cowie

2015

Cold Spring Harbor Perspectives in Medicine

253

163

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The epidemiology of hepatitis B virus (HBV) infection is geographically diverse, with population prevalence, age and mode of acquisition, and likelihood of progression to chronic infection mutually interdependent. The burden of chronic HBV infection is increasingly being recognized, with cirrhosis and liver cancer attributable to HBV continuing to increase. The outcomes of chronic HBV infection are affected by a range of factors, including viral genotype, the presence of coinfections with other blood-borne viruses, and the impact of other causes of liver disease. The increased recognition of HBV infection as a leading cause of death globally has resulted in the development of new structures and policies at the international level; immediate attention to implementing these strategies is now required.

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Section: Natural History Infection and Immunitymentioning

confidence: 99%

Section: Natural History Infection and Immunitymentioning

confidence: 99%

Hepatitis B Virus Epidemiology

MacLachlan

Cowie

2015

Cold Spring Harbor Perspectives in Medicine

253

163

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“…The HBsAg seroclearance was defined as attaining seronegative in any of the follow-up tests. The long-term changes in serum HBV DNA and ALT levels were also evaluated using the same definitions as described previously (31). Newly diagnosed liver cirrhosis (32) via ultrasound during follow-up were also identified to clarify whether the relationship between adipocytokine and HCC were mediated through cirrhosis.…”

Section: Data Collectionmentioning

confidence: 99%

Plasma Adipokines and Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Virus–Infected Carriers: A Prospective Study in Taiwan

Chen

Yang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Obesity is considered a risk factor for hepatocellular carcinoma (HCC). The relationship between adipocytokine and HCC in hepatitis B virus (HBV) carriers remains unclear. We prospectively investigated the association of adiponectin, leptin, and visfatin levels with HCC.Methods: We conducted a nested case-control study in a community-based cohort with 187 incident HCC and 374 HCC-free HBV carriers. Unconditional logistic regression was conducted to estimate the ORs and 95% confidence intervals (CI).Results: Adiponectin, but not leptin and visfatin, levels were associated with an increased risk of HCC after adjustment for other metabolic factors and HBV-related factors. The risk was increased [OR ¼ 0.51; 95% CI, 0.12-2.11; OR ¼ 4.88 (1.46-16.3); OR ¼ 3.79 (1.10-13.0); OR ¼ 4.13 (1.13-15.1) with each additional quintiles, respectively] with a significant dose-response trend (P trend ¼ 0.003). HCC risk associated with higher adiponectin level was higher in HBV carriers with ultrasonographic fatty liver, genotype C infection, higher viral load, and with elevated alanine aminotransferase. Longitudinally, participants with higher adiponectin were less likely to achieve surface antigen of hepatitis B virus (HBsAg) seroclearance and more likely to have persistently higher HBV DNA. Eventually, they were more likely to develop liver cirrhosis [OR ¼ 1.65 (0.62-4.39); OR ¼ 3.85 (1.47-10.1); OR ¼ 2.56 (0.96-6.84); OR ¼ 3.76 (1.33-10.7) for the second, third, fourth, and fifth quintiles, respectively; P trend ¼ 0.017] before HCC.Conclusions: Elevated adiponectin levels were independently associated with an increased risk of HCC. Impact: Adiponectin may play different roles in the virus-induced and metabolic-related liver diseases, but the underlying mechanism remains unknown. Cancer Epidemiol Biomarkers Prev; 23(8); 1659-71. Ó2014 AACR.

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“…Based on a large nationwide Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus (REVEAL-HBV) study performed in Taiwan for CHB without alcoholism, detectable serum HBV DNA at study entry is demonstrated to be a significant risk predictor of HCC in HBV patients [21][22][23]. Those with detectable HBsAg are at 5-to 98-fold higher risk of developing HCC [24].…”

Section: Prognosismentioning

confidence: 99%

Treatment and Prognosis of Hepatitis B Virus Concomitant with Alcoholism

Lin¹,

Lin²,

Yang³

2017

Advances in Treatment of Hepatitis C and B

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Hepatitis B virus (HBV) infection is a global disease worldwide. The Asia-Pacific regionhas a high prevalence of viral hepatitis, and Taiwan is a region of high prevalence of chronic hepatitis B (CHB) with increasing alcoholic liver disease. We have investigated the prognosis and treatment of patients with concomitant hepatitis B virus (HBV) infection and alcoholism. The 10-year cumulative incidence of hepatocellular carcinoma (HCC) is much higher in patients with concomitant alcoholism and HBV infection than in those with alcoholism or HBV infection alone. Treatment with antiviral therapy and abstinence may be started in patients with decompensated cirrhosis and compensated cirrhosis with high HBV DNA. In pre-cirrhotic cases, treatment with antiviral therapy and abstinence may be started in patients with persistently elevated ALT levels and high HBV DNA, and significant fibrosis with minimal elevated or normal ALT levels and mild high HBV DNA. Treatment with antiviral therapy and abstinence reduces the incidence of HCC in patients with concomitant HBV infection and alcoholism. In conclusion, patients with concomitant HBV infection and alcoholism have high incidence of cirrhosis, HCC, and mortality. Treatment with antiviral therapy and abstinence may be started to reduce the incidence of cirrhosis, HCC, and mortality in these patients.

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Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma

Cited by 235 publications

References 33 publications

Hepatitis B Virus Epidemiology

Hepatitis B Virus Epidemiology

Plasma Adipokines and Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Virus–Infected Carriers: A Prospective Study in Taiwan

Treatment and Prognosis of Hepatitis B Virus Concomitant with Alcoholism

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