Changes in serum levels of glucosamine and sulphate after ingestion of glucosamine sulphate with and without simultaneous ingestion of glucose

Biggee, Beth Anne; Blinn, Christina M; Nuite, Melynn; McAlindon, Timothy E.; Silbert, Jeremiah E.

doi:10.1136/ard.2007.073205

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…There was no other information in the literature relating to human blood glucosamine levels. After trying several techniques, we found that we could measure glucosamine down to 0.0005 mM by use of high-performance liquid ion-exchange chromatography with a pulsed amperometric detection method using a Metrrohm-Peak 817 Bioscan apparatus (Biggee et al 2006(Biggee et al , 2007a. Eighteen subjects were recruited and given 1500 mg of glucosamine sulfate after an overnight fast.…”

Section: Glyco-forum Sectionmentioning

confidence: 99%

Dietary glucosamine under question

Silbert¹

2009

Glycobiology

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Annual sales of glucosamine as a neutraceutical for affecting cartilage in treatment of osteoarthritis are close to a billion dollars, but recent clinical studies have currently raised severe criticism regarding its functional value. Additional doubts can be raised by the knowledge of the well-defined cellular steps in glucosamine formation and production of glycosaminoglycans such as chondroitin. Glucosamine is produced in an activated state from glucose by essentially all cells for incorporation into glycosaminoglycans and glycoproteins, and there have been no reports of any deficiencies in its production under any conditions. Nevertheless, many investigations of glucosamine, using cells or tissues, have claimed effects on cartilage and chondroitin sulfate. The significance of these studies is questionable since they have invariably been with concentrations that were 10- to 1000-fold higher than has been found in human serum or plasma after glucosamine ingestion. Experiments with cells or tissues using glucosamine in the low concentrations found after ingestion need to be examined before any conclusions are drawn concerning its direct action on cartilage and its potential for modifying osteoarthritis.

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Section: Glyco-forum Sectionmentioning

confidence: 99%

Dietary glucosamine under question

Silbert¹

2009

Glycobiology

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Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine

Olivieri

Tipton

O'Sullivan

2012

Biochimica et Biophysica Acta (BBA) - General Subjects

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Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities

et al. 2013

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The aim of this paper was to provide an overview of the current knowledge and understanding of the potential beneficial physiological effects of glucosamine (GlcN) on joint health. The objective was to reach a consensus on four critical questions and to provide recommendations for future research priorities. To this end, nine scientists from Europe and the United States were selected according to their expertise in this particular field and were invited to participate in the Hohenheim conference held in August 2011. Each expert was asked to address a question that had previously been posed by the chairman of the conference. Based on a systematic review of the literature and the collection of recent data, the experts documented the effects of GlcN on cartilage ageing, metabolic/kinetic and maintenance of joint health as well as reduction of risk of OA development. After extensive debate and discussion the expert panel addressed each question and a general consensus statement was developed, agreeing on the current state-of-the-art and future areas for basic and clinical studies. This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissues.

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Changes in serum levels of glucosamine and sulphate after ingestion of glucosamine sulphate with and without simultaneous ingestion of glucose

Cited by 3 publications

References 10 publications

Dietary glucosamine under question

Dietary glucosamine under question

Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine

Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities

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