Changes in Serum Levels of Il-6 in the Early Postoperative Period After Preemptive Analgesia With Nimesulide, Metamizole Sodium and Placebo in Removal of Impacted Mandibular Third Molars

Abstract

The aim of this study is to determine the change in IL-6 serum levels in patients undergoing preemptive analgesia and surgical removal of an impacted mandibular third molar. Study Design: This is a prospective, doubleblind, placebo-controlled study in 80 patients who had an atypical extraction of an impacted mandibular third molar. Results: After surgical removal of impacted mandibular third molars, elevated levels of IL-6 in the early postoperative period were found, and the highest level was 14 pg/ml. Conclusion: Postoperative IL-6 levels rise regardless of the medication used for preemptive analgesia. In the group treated with nimesulide, a trend to reducing IL-6 levels was observed, but further study in a larger number of patients is needed.

A survey and optical microscopy in pilot comparative analysis of generic and original nimesulide granules

“…Prevention and management of these processes is an important objective in dentistry. According to literature, a scientifically justified drug for controlling pain and inflammation is nimesulide, which is due to its high clinical effectiveness, safety profile and short onset of action [ 25 , 26 , 27 , 28 ]. According to the results of our survey, dentists most frequently use nimesulide to manage inflammation following dental interventions.…”