Changes in Serum Levels of Cartilage Oligomeric Matrix Protein after Estrogen and Alendronate Therapy in Postmenopausal Women

Seo, Seok Kyo; Yang, Hyo In; Lim, Kyung Jin; Jeon, Young Eun; Choi, Young Sik; Cho, SiHyun; Lee, Byung Seok

doi:10.1159/000339934

Cited by 14 publications

(10 citation statements)

References 85 publications

(59 reference statements)

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“…Sclerostin is expressed by osteocytes [1]. Estrogens are potent survival factors for osteocytes, as estrogen deprivation significantly increases osteocyte death [20,21]. Estrogen also prevents sclerostin upregulation in osteocytic cells [11].…”

Section: Discussionmentioning

confidence: 99%

Effects of Sex Steroids on Serum Sclerostin Levels during the Menstrual Cycle

Çidem

Usta²,

Karacan

et al. 2013

Gynecol Obstet Invest

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Background/Aims: Previous studies on the effects of estrogen on sclerostin regulation were conducted in postmenopausal women in humans or animals following estrogen treatment or induced estrogen deficiency. The aim of this study was to evaluate the effects of sex hormones on serum sclerostin levels in premenopausal women with normal menstrual cycles. Methods: A prospective observational clinical study. 80 voluntary premenopausal women were recruited for the study. Data from 31 patients were available for the statistical analysis. Serum sclerostin, free estradiol, free testosterone, and progesterone levels were measured during the menstruation, late follicular and mid-luteal phases. The unique protocol IDs were BEAH FTR-4 and NCT01418924 at ClinicalTrials.gov ID. Results: Serum sclerostin values were 1.03 ± 0.58 ng/ml during the menstruation phase, 1.0 ± 0.36 ng/ml during the late follicular phase, and 1.18 ± 0.67 ng/ml during the mid-luteal phase (p = 0.543). There was no significant relationship between serum levels of sex steroids and sclerostin. Conclusions: Previous studies have not investigated the impact of sex hormone fluctuations on serum sclerostin levels during the menstrual cycle. The present study shows that serum sclerostin levels were not affected by sex steroids in premenopausal women with normal menstrual cycles.

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Section: Discussionmentioning

confidence: 99%

Effects of Sex Steroids on Serum Sclerostin Levels during the Menstrual Cycle

Çidem

Usta²,

Karacan

et al. 2013

Gynecol Obstet Invest

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“…Hormone replacement therapy (HRT) has been one of the most broadly prescribed medications in recent centuries to relieve menopause symptoms [5], and has demonstrated long-term joint protection as well as slowing of cardiovascular and neurological deterioration [6,7,8,9]. However, the upward trend regarding HRT prescription changed course after the results of the Heart and Estrogen/Progression Replacement Study (HERS) [10] and the Women's Health Initiative (WHI) randomized controlled trial [11] were published in 1998 and 2002, respectively.…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Attitude towards Menopause and Hormone Replacement Therapy in Chinese Women

Jin

Tao

Teng

et al. 2014

Gynecol Obstet Invest

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Objective: To explore the knowledge and prevalence of menopausal symptoms as well as the use and attitude toward hormone replacement therapy (HRT) in Chinese women. Methods: A cross-sectional study was conducted between May 2011 and April 2012 in Shanghai, China. The structured questionnaire addressing sociodemographic characteristics, knowledge and prevalence of menopausal symptoms, and knowledge and attitude towards HRT and its use were investigated. Results: 3,619 women aged 40-65 years were included in the analysis. The majority of the women had knowledge of menopause. Symptoms were prevalent in 16.1% of premenopausal women and in 49.3% of peri-, post- and surgical-menopausal women. Back and joint pain, sleeplessness, fatigue and sweating/hot flushes were frequently reported. HRT awareness among women was 3.5% and was related to menopausal, working and marital status; 75 (2.1%) women had used or were using HRT, of which 57.3% used HRT with a doctor's prescription and 29.3% experienced side effects from the use of HRT. Conclusion: Most Chinese women had knowledge of menopause and thought menopausal symptoms should not be treated. The awareness of HRT was poor and influenced by menopausal, working and marital status. Chinese health care providers have to assume responsibility for educating women about menopause and HRT use.

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“…It is also one of the reasons that OA prevalence is higher in women than in men [Spector et al, 1997;Wluka et al, 2000;Claasen et al, 2008]. Many studies report that phytoestrogen by oral administration exerts a positive effect through upregulation of COL2A1, proteoglycan, and the cartilage oligomeric matrix in menopausal and nonmenopausal OA patients [Seo et al, 2012;Maneix et al, 2014]. In addition to the direct or indirect protective effect of these estrogen-related drugs and modulators (including phytoestrogen) on articular cartilage, subchondral bone, and the surrounding joint tissues including the synovium and muscle, the joint tissues themselves interact with each other, thereby maintaining the organ homeostasis of the joint as a whole, and finally delay joint degeneration [Karsdal et al, 2012;Xiao et al, 2016].…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Prethanol Extract of <b><i>Trifolium pratense</i></b> Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes

Lee

Moon²,

Han³

et al. 2018

Cells Tissues Organs

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Background: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of other catabolic factors that contribute to cartilage degradation. Trifolium pratense L. (red clover) has been used as a medicinal plant in many countries and as a source of nutraceuticals to alleviate the symptoms of menopause. Objectives: In this study, we aimed to evaluate the anticatabolic effect of 40% prethanol extract of T. pratense (40% PeTP) on IL-1β-stimulated chondrocytes. Methods: Primary rat chondrocytes were pretreated with 40% PeTP for 1 h before stimulation with IL-1β (20 ng/mL). The production of nitrite, prostaglandin E₂ (PGE₂), and aggrecan was measured by using Griess reagent and ELISA. Protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)-4, mitogen-activated protein kinase (MAPK), and the nuclear factor (NF)-κB p65 subunit was measured by using Western blotting. Results: PeTP (40%) significantly inhibited the IL-1β-induced expression of nitrite, iNOS, PGE₂, COX-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4 in isolated primary rat chondrocytes. Furthermore, 40% PeTP decreased the IL-1β-induced degradation of aggrecan, the phosphorylation of MAPKs, and the nuclear translocation of the NF-κB p65 subunit. Conclusion: These results suggested that 40% PeTP has a chondroprotective effect on inflammation and may be a potential preventative agent for OA progression.

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Changes in Serum Levels of Cartilage Oligomeric Matrix Protein after Estrogen and Alendronate Therapy in Postmenopausal Women

Cited by 14 publications

References 85 publications

Effects of Sex Steroids on Serum Sclerostin Levels during the Menstrual Cycle

Effects of Sex Steroids on Serum Sclerostin Levels during the Menstrual Cycle

Knowledge and Attitude towards Menopause and Hormone Replacement Therapy in Chinese Women

The Effect of the Prethanol Extract of <b><i>Trifolium pratense</i></b> Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes

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