Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation

Sato, Yoshinobu; Watanabe, Hidenori; Kameyama, Hitoshi; Kobayashi, Takashi; Yamamoto, Shinji; Takeishi, Toshiyuki; Hirano, Keisuke; Oya, Hiroshi; Nakatsuka, Hideki; Watanabe, Toshiaki; Kokai, H.; Yamagoe, Satoshi; Suzuki, Kazuo; Oya, Kiyofumi; Kojima, Kensuke; Hatakeyama, K.

doi:10.1016/j.transproceed.2004.07.006

Cited by 31 publications

(19 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies using this ELISA protocol reported the presence of LECT2 levels in human serum or plasma in the range of 1-15 ng/mL (18)(19)(20). Recently, Ando et al reported LECT2 levels of 19.7 ± 3.4 ng/mL in heparinized plasma from healthy volunteers with the conventional ELISA protocol (21).…”

Section: Discussionmentioning

confidence: 96%

Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

et al. 2013

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

et al. 2013

View full text Add to dashboard Cite

“…Following an overnight fast, venous blood samples were taken from each patient. Serum levels of LECT2 were measured by an Ab-Match ASSEMBLY Human LECT2 kit (MBL Co.) (26,27). …”

Section: Human Clinical Studiesmentioning

confidence: 99%

“…To characterize the role of LECT2 in humans, using enzyme-linked immunosorbent assays we measured serum LECT2 levels in participants who visited the hospital for a complete physical examination (26,27) (Supplementary Table 2). We found a significant positive correlation between serum LECT2 levels and BMI and waist circumference ( Fig.…”

Section: Circulating Lect2 Levels Correlate With Adiposity and Insulimentioning

confidence: 99%

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

et al. 2014

View full text Add to dashboard Cite

Recent articles have reported an association between fatty liver disease and systemic insulin resistance in humans, but the causal relationship remains unclear. The liver may contribute to muscle insulin resistance by releasing secretory proteins called hepatokines. Here we demonstrate that leukocyte cell–derived chemotaxin 2 (LECT2), an energy-sensing hepatokine, is a link between obesity and skeletal muscle insulin resistance. Circulating LECT2 positively correlated with the severity of both obesity and insulin resistance in humans. LECT2 expression was negatively regulated by starvation-sensing kinase adenosine monophosphate-activated protein kinase in H4IIEC hepatocytes. Genetic deletion of LECT2 in mice increased insulin sensitivity in the skeletal muscle. Treatment with recombinant LECT2 protein impaired insulin signaling via phosphorylation of Jun NH2-terminal kinase in C2C12 myocytes. These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin resistance.

show abstract

“…[16][17][18][19] LECT2 serum levels are elevated in hepatic disorders. [20][21][22] A cytokine is involved in the regulation of hepatocyte activity and functions as an immunomodulator. 23 A polymorphism (Val58Ile) in the LECT2 gene (LECT2) was demonstrated to be a risk factor for the progression of rheumatoid arthritis.…”

Section: Pathogenesis Of Hepatic Alect2 Amyloidosismentioning

confidence: 99%

Leukocyte cell-derived chemotaxin 2 (LECT2)–associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

Mereuta

Theis

Vrana

et al. 2014

Blood

View full text Add to dashboard Cite

show abstract

Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation

Cited by 31 publications

References 5 publications

Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

Leukocyte cell-derived chemotaxin 2 (LECT2)–associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

Contact Info

Product

Resources

About