Changes in serum iron and ferritin concentrations associated with surgery.

Fitzsimons, Edward J.; Govostis, Michael C.

doi:10.1093/clinchem/32.1.201a

Cited by 2 publications

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“…Pretreatment serum ferritin concentration was high in all three groups. Ferritin concentration in blood is considered to be a specific indicator of body Fe stores (Lipschitz et al 1974); however, the concentrations can rise following an inflammatory response, irrespective of Fe status (Dallman et al 1981;Harju et al 1984;Henderson, 1984;Fitzsimons & Govostis, 1986;Taylor et al 1993). Recent reports indicate that ferritin synthesis is stimulated in pulmonary tuberculosis as a consequence of the inflammatory process (Wessels et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

et al. 2003

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Anaemia is a common complication of pulmonary tuberculosis. The precise mechanism of anaemia in pulmonary tuberculosis is not clearly known, but anaemia of inflammation as well as of Fe deficiency has been implicated. Both are common in developing countries. It is extremely difficult to distinguish anaemia of Fe deficiency from anaemia of inflammation with the haematological indices used routinely. Therefore, Fe preparations are usually prescribed for all anaemic patients irrespective of the aetiology. This approach has been questioned. The present study aimed to assess the effect of Fe supplementation on anaemic patients with pulmonary tuberculosis. Adult male patients 15–60 years of age with pulmonary tuberculosis and a blood haemoglobin concentration 80–110 g/l were included in the study; healthy adult males matched for age and socio-economic status were taken as controls. Blood haemoglobin concentration, total erythrocyte count (TEC), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin and serum Fe, total Fe-binding capacity and ferritin were estimated before treatment and 1, 2 and 6 months after treatment. The patients were divided randomly into three groups and during the initial 2 months of treatment were provided with one of three supplementary regimens consisting of placebo, Fe alone or Fe with other haematinics. Significant improvements in haematological indices and Fe status were noticed in all three groups. Blood haemoglobin concentration, MCV and PCV were significantly higher at 1 month in both Fe-supplemented groups than the placebo group. This difference, however, disappeared at 2 and 6 months with similar values in all three groups. The increase of other haematological indices was similar in all groups. Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months. There was a consistent increase in TEC and decrease in ferritin values up to 6 months in all groups. Radiological and clinical improvement was similar in all three groups. These observations suggest that Fe supplementation in mild to moderate anaemia associated with pulmonary tuberculosis accelerated the normal resumption of haematopoiesis in the initial phases by increasing Fe saturation of transferrin. However, consistent improvement of haematological status was dependent only on the improvement of the disease process.

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Section: Discussionmentioning

confidence: 99%

Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

et al. 2003

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“…Plasma ferritin concentrations are significantly higher in all the malaria groups than in the controls despite associated anaemia. Ferritin is a positive APP and is known to increase in infections and injury (Harju et al 1984;Fitzsimons & Govostis, 1986). Marked increases in serum ferritin are reported in malaria patients (Phillips et al 1986;Adelekan & Thurnham, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Plasma Fe concentration was not altered to any significant extent in the malaria patients in comparison with the controls. A low Fe content of plasma is commonly noticed in infection (Keusch, 1990) and surgical stress (Fitzsimons & Govostis, 1986) and is attributed to decreased transferrin saturation (Keusch, 1990). In the present study, raised transferrin saturation encountered in malaria patients is probably due to continuing erythrocyte lysis.…”

Section: Discussionmentioning

confidence: 99%

Influence of malaria on markers of iron status in children: implications for interpreting iron status in malaria-endemic communities

1997

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To investigate Fe nutritional indices in malaria infection in children, haematology (blood haemoglobin, plasma ferritin, transferrin, Fe, and transferrin saturation), acute phase markers (albumin and caeruloplasmin) and liver function tests were studied in fifty consecutive cases of severe and mild falciparum malaria, fifty matched controls and twenty-three cases of asymptomatic malaria. Blood haemoglobin and transferrin were lower, while ferritin and transferrin saturation were higher, in groups with symptomatic malaria in comparison with the control group. The differences were greatest with the severest form of the disease. There were no differences between any of the groups in plasma Fe. Plasma transferrin correlated directly with albumin in asymptomatic, mild and severe malaria groups (r 0.48, 0.65 and 0.83; P < 0.05, P (0.01 and P < 0,001 respectively), and inversely with caeruloplasmin (r -0.65, -0.34 and -0.43; P < 0.01, P < 0.05 and P < 0.01 respectively). For ferritin, the correlation was inverse with albumin (r -0.65, -0.57 and -0.64; P < 0.01, P < 0.001 and P < 0.001 respectively and direct with caeruloplasmin (r 0.83, 0.21 and 0.49, P < 0.001, NS and P < 0401 respectively). Multiple regression analysis on data from all patients combined indicated that albumin, and to a lesser extent alanine aminotransferase (EC 2.6.1.2) activity, explained 62 % of the variance in transferrin. Caeruloplasmin, parasite count and albumin explained 59 % of the variance in ferritin, and transferrin and unconjugated bilirubin explained 62 % of the variance in Fe values. In conclusion, these data suggest that low transferrin and high ferritin values are primarily due to the acute phase response.

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Changes in serum iron and ferritin concentrations associated with surgery.

Cited by 2 publications

References 0 publications

Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

Influence of malaria on markers of iron status in children: implications for interpreting iron status in malaria-endemic communities

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