Changes in Serum Interleukin-2, -6, and -8 Levels Before and During Treatment With Risperidone and Haloperidol

Zhang, Xiang Yang; Zhou, Dong; Cao, Lian Yuan; Zhang, Pei Yan; Wu, Gui Ying; Shen, Yanying

doi:10.4088/jcp.v65n0710

Cited by 177 publications

(116 citation statements)

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“…One additional study found no change in adiponectin after 4 weeks of olanzapine treatment (Hosojima et al, 2006). Similarly, IL-6 levels were elevated in patients with schizophrenia compared to controls but appeared unchanged after 12 weeks of risperidone treatment (Zhang et al, 2004b). Our study extends this work by prospectively evaluating changes in adiponectin, IL-6, and other important risk markers in patients early in treatment who received SGAs for a longer duration (approximately six months).…”

Section: Introductionsupporting

confidence: 49%

Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects

Graham

Cho

Brownley

et al. 2008

Schizophrenia Research

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Objective-To examine prospective changes in cardiovascular disease (CVD) and type-2 diabetes risk factors in young adult first episode psychotic (FEP) patients treated with second generation antipsychotic medications.Methods-At baseline, fasting serum and anthropometric measures were obtained from 45 FEP patients and 41 healthy adults (controls) of similar age, ethnicity and sex; sixteen of the FEP patients remained on the same antipsychotic medication and were available for a second blood draw at 24 weeks of treatment. Serum was assayed for glucose, insulin, triglycerides, total cholesterol and high and low density lipoproteins (HDL, LDL), adiponectin, leptin, interleukin 6, E-selectin and VCAM-1. Wilcoxon nonparametric tests were used to compare risk markers between the FEP and control group at baseline and to evaluate pre-post treatment changes within the FEP group.Results-At baseline, the distributions of risk marker values were similar between the two groups and the percentages of FEP patients and healthy controls who were overweight/obese, dyslipidemic, hyperglycemic, and hyperinsulinemic did not differ. At 24 weeks, compared to baseline, FEP patients showed significant increases in BMI (p=0.0002), glucose (p=0.0449), insulin (p=0.0161), cholesterol (p=0.0129), leptin (p=0.0215), and E-selectin (p=0.0195), and a decrease in adiponectin (p=0.0371).Conclusions-Among patients with first episode psychosis, 6-month treatment with second generation antipsychotics is associated with the exacerbation of pre-existing and emergence of new CVD and diabetes risk factors.

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Section: Introductionsupporting

confidence: 49%

Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects

Graham

Cho

Brownley

et al. 2008

Schizophrenia Research

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“…A combination of genetic and environmental factors resulting in some immune dysregulation in general and the lack of the CMV IgG antibodies in particular could be the most plausible speculations. While there are no specific research results supporting this finding in existing literature, the activation of the immune system and prolonged neuroinflammation are well established phenomena implicated in the etiopathogenesis and symptomatology of schizophrenia (Lin et al, 1998;Nikkila et al, 1999;Kim et al, 2000;Theodoropoulou et al, 2001;Ebrinc et al, 2002;Patterson, 2002;Zhang et al, 2002;Garver et al, 2003;Zhang et al, 2004;Coelho et al, 2008;Potvin et al, 2008;Doorduin et al, 2009;Kim et al, 2009;Song et al, 2009;Drexhage et al, 2010;Romero et al, 2010;Drexhage et al, 2011;Weigelt et al, 2011;Beumer et al, 2012;Brito-Melo et al, 2012). Other mechanisms could also be considered.…”

Section: Discussionmentioning

confidence: 56%

Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel

Li¹,

Weber²,

Fisher³

et al. 2013

Schizophrenia Research

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a b s t r a c t a r t i c l e i n f oIntroduction: Multiple studies have documented immune activation in many individuals with schizophrenia suggesting that antigens capable of generating a prolonged immune response may be important environmental factors in many cases of this disorder. While existing studies have found single-agent associations of antibodies to food and neurotropic infectious agents with schizophrenia, a simultaneous examination of multiple agents may shed light on agent interactions or possible etiopathogenic pathways. Methods: We used traditional regression and novel statistical techniques to examine associations of single and combined infectious and food antigens with schizophrenia. We tested 6106 serum samples from 855 cases and 1165 matched controls. Results: Higher antibody levels to casein were borderline significant in the prediction of schizophrenia (HR = 1.08, p = 0.06). Study participants with higher cytomegalovirus (CMV) IgG antibody levels had a reduced risk of developing schizophrenia (HR = 0.90; p = 0.02). While IgG antibodies to gliadin, Toxoplasma gondii, vaccinia, measles, and human herpesvirus-6 (HHV-6) showed no significant independent associations with schizophrenia, the increase in antibody levels to several combinations of agents, to include casein, measles, CMV, T. gondii and vaccinia, was predictive of an 18-34% increase in the risk of developing schizophrenia. Conclusion: Certain patterns of antibodies, involving some agents, were predictive of developing schizophrenia, with the magnitude of association rising when the level of antibodies increased to two or more agents. A heightened antibody response to a combination of several infectious/food antigens might be an indicator of an altered immune response to antigenic stimuli.Published by Elsevier B.V.

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“…Доля редукции баллов по субшкалам шка-лы PANSS к концу 6-недельного лечения составила 23,0-25,6%, что согласуется с соответствующими данными ли-тературы [14]. Относительно небольшие, с клинической точки зрения, изменения выраженности симптоматики обусловливают необходимость дальнейшей разработки методов повышения эффективности ААП, в том числе иммунологических, и первые шаги в этом направлении уже сделаны [15][16][17].…”

Section: результаты и обсуждениеunclassified

An effect of quetiapine on the immune system of patients with schizophrenia

Лобачева

Semke

et al. 2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Changes in Serum Interleukin-2, -6, and -8 Levels Before and During Treatment With Risperidone and Haloperidol

Cited by 177 publications

References 0 publications

Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects

Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects

Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel

An effect of quetiapine on the immune system of patients with schizophrenia

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