1998
DOI: 10.1016/s1096-6374(98)80301-8
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Changes in serum insulin-like growth factor binding protein-2, -3, and -6 levels in patients with chronic renal failure following renal transplantation

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Cited by 7 publications
(11 citation statements)
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“…It has been accepted widely that growth retardation in children with CRF results in part from inhibition of IGF action by an excess of plasma IGFBP-1, -2 and -3 (Rajaram et al 1997). In accordance with recent data reported by others (Fukuda et al, 1997;Powell et al, 1997) the present study shows that plasma from CRF patients usually also contains high levels of IGFBP-6. Although other factors (e.g.…”
Section: Discussionsupporting
confidence: 92%
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“…It has been accepted widely that growth retardation in children with CRF results in part from inhibition of IGF action by an excess of plasma IGFBP-1, -2 and -3 (Rajaram et al 1997). In accordance with recent data reported by others (Fukuda et al, 1997;Powell et al, 1997) the present study shows that plasma from CRF patients usually also contains high levels of IGFBP-6. Although other factors (e.g.…”
Section: Discussionsupporting
confidence: 92%
“…Several studies suggest the possibility that IGFBP-6 contributes as an autocrine modulator of the IGF-IIinduced progression of tumour growth (Srinivasan et al, 1996;Babajko et al, 1997). In accordance with recent data reported by others (Fukuda et al, 1997;Powell et al, 1997) the present study shows that plasma from CRF patients usually also contains high levels of IGFBP-6. Apparently, only in relatively extreme cases, such as patients suffering from NICTH (who usually have large tumours which are known to produce excessive amounts of pro-IGF-II), tumour-derived IGFBP-6 may ultimately contribute significantly to the circulating pool.…”
Section: Figsupporting
confidence: 92%
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“…In one study, IGFBP-4 and IGFBP-6 levels were found to be increased in the serum of patients with chronic renal failure [40], most likely as a consequence of reduced renal clearance, but again in our study population renal transplant function was only slightly reduced. The observation of increased IGFBP-4 and IGFBP-6 levels is consistent with previous data reported for smaller patient cohorts [38,39,41]. The potential effect of other immunosuppressive drugs, such as cyclosporine, on serum IGF/IGFBP components has not been investigated so far.…”
Section: Discussionsupporting
confidence: 88%