Changes in serum insulin-like growth factor binding protein-2, -3, and -6 levels in patients with chronic renal failure following renal transplantation

Izumi, Fujio; Hizuka, Naomi; Okubo, Yumiko; Takano, Kazue; Asakawa-Yasumoto, Kumiko; Shizume, Kazuo; Demura, Hiroshi; Naoki, Katsuhiko; Ishikawa, Nobuo; Toma, Hiroshi

doi:10.1016/s1096-6374(98)80301-8

Cited by 7 publications

(11 citation statements)

References 22 publications

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“…It has been accepted widely that growth retardation in children with CRF results in part from inhibition of IGF action by an excess of plasma IGFBP-1, -2 and -3 (Rajaram et al 1997). In accordance with recent data reported by others (Fukuda et al, 1997;Powell et al, 1997) the present study shows that plasma from CRF patients usually also contains high levels of IGFBP-6. Although other factors (e.g.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies suggest the possibility that IGFBP-6 contributes as an autocrine modulator of the IGF-IIinduced progression of tumour growth (Srinivasan et al, 1996;Babajko et al, 1997). In accordance with recent data reported by others (Fukuda et al, 1997;Powell et al, 1997) the present study shows that plasma from CRF patients usually also contains high levels of IGFBP-6. Apparently, only in relatively extreme cases, such as patients suffering from NICTH (who usually have large tumours which are known to produce excessive amounts of pro-IGF-II), tumour-derived IGFBP-6 may ultimately contribute significantly to the circulating pool.…”

Section: Figsupporting

confidence: 92%

“…For most of the patients investigated, however, there was no evidence for an increased secretion of IGFBP-6 in the circulation either since the mean plasma levels lie within the normal range. This was also found by Fukuda et al (1997), who determined IGFBP-6 by Western immunoblotting in plasma from several adult CRF patients 1 day before and during 14 days following renal transplantation. It has been accepted widely that growth retardation in children with CRF results in part from inhibition of IGF action by an excess of plasma IGFBP-1, -2 and -3 (Rajaram et al 1997).…”

Section: Figsupporting

confidence: 67%

“…Baxter and Saunders developed a radioimmunoassay (RIA) for human IGFBP-6 and demonstrated it to be present not only in CSF but also in serum and several other body fluids (Baxter & Saunders, 1992). Recently, it has been reported that sera from patients with chronic renal failure (CRF) may contain high amounts of IGFBP-6 as measured either by Western immunoblotting (Fukuda et al, 1997) or RIA . The accumulation of IGFBP-6 in CRF serum may contribute to the apparent interference with IGF-(II) mediated growth of cartilage and bone in these patients.…”

mentioning

confidence: 99%

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Circulating levels of human insulin‐like growth factor binding protein‐6 (IGFBP‐6) in health and disease as determined by radioimmunoassay

Doorn

Ringeling

Shmueli

et al. 1999

Clinical Endocrinology

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Measurements of IGFBP-6 have been shown so far to be of relatively minor clinical relevance. The exceptions are chronic renal failure patients and subjects with large tumours and non-islet cell tumour induced hypoglycaemia who may exhibit elevated circulating levels of this IGFBP. The physiological significance of this observation remains to be elucidated. The possibility of quantifying IGFBP-6 by specific RIA will facilitate further in vitro and in vivo studies of its regulation and function in man.

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Section: Discussionsupporting

confidence: 92%

Section: Figsupporting

confidence: 92%

Section: Figsupporting

confidence: 67%

mentioning

confidence: 99%

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Circulating levels of human insulin‐like growth factor binding protein‐6 (IGFBP‐6) in health and disease as determined by radioimmunoassay

Doorn

Ringeling

Shmueli

et al. 1999

Clinical Endocrinology

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“…In one study, IGFBP-4 and IGFBP-6 levels were found to be increased in the serum of patients with chronic renal failure [40], most likely as a consequence of reduced renal clearance, but again in our study population renal transplant function was only slightly reduced. The observation of increased IGFBP-4 and IGFBP-6 levels is consistent with previous data reported for smaller patient cohorts [38,39,41]. The potential effect of other immunosuppressive drugs, such as cyclosporine, on serum IGF/IGFBP components has not been investigated so far.…”

Section: Discussionsupporting

confidence: 88%

The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients

et al. 2009

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The post-transplant bone disease of the peripheral skeleton in pediatric renal transplant recipients is characterized by an inadequately thin bone cortex in relation to muscular force. A major hormonal modulator of periosteal growth is the insulin-like growth factor (IGF)/IGF binding protein (IGFBP) system. We therefore hypothesized that the reduced cortical thickness in these patients may be due to functional IGF deficiency. To test this hypothesis, we investigated 55 patients (mean estimated glomerular filtration rate 86.3 +/- 30.0 ml/min/1.73 m(2)) in a cross-sectional study. Parameters of macroscopic bone architecture and forearm muscle size were analyzed by peripheral quantitative computed tomography (pQCT), and serum IGF/IGFBP system components were measured by specific radioimmunoassays. The mean (+/- standard deviation) standardized serum IGF-I (0.20 +/- 1.16 score) level was normal, while the mean IGF-II (1.16 +/- 0.11 score) level was significantly elevated. Serum IGFBP-1 and IGFBP-2 levels were not altered, whereas the IGFBP-3 (1.34 +/- 0.15 score) level was significantly increased. The serum IGFBP-4 level was slightly elevated (by 11%), the IGFBP-6 level was markedly (2.3-fold) elevated, while the IGFBP-5 level was comparable to that of the control. The respective age-adjusted cortical thickness at both the proximal (r = 0.407, P < 0.005) and distal (r = 0.383, P < 0.01) forearm was positively correlated with the standardized serum IGF-I level. In conclusion, the serum IGF/IGFBP system in pediatric renal transplant recipients is characterized by an increase in the levels of the inhibitory IGFBPs, IGFBP-3, -4 and -6, resulting in a functional IGF deficiency. The positive correlation of IGF-I with cortical thickness underlines the importance of this hormonal system in the modeling of bone, particularly periosteal growth.

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Acromegaly and end-stage renal disease: A diagnostic challenge

Müssig¹,

Gallwitz²,

Ranke

et al. 2006

J Endocrinol Invest

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Chronic renal failure is associated with an impairment of the GH/IGF-I axis. We report the diagnostic challenges in a 72-yr-old female suffering from end-stage renal disease and presenting with clinical findings suggestive of acromegaly. GH was not suppressed during an oral glucose tolerance test, but rose paradoxically. However, serum IGF-I levels were within the normal range. IGF-binding proteins (IGFBP)-2 and -3 were markedly elevated and GH-binding protein (GHBP) was diminished. Clinical findings suspicious of acromegaly could be ascribed to pre-existing characteristics and consequences of end-stage renal disease. This suggested that the disturbances of the GH/IGF-I axis in our patient were due to chronic renal disease, rather than acromegaly. In the work-up for acromegaly, clinicians should be alerted to GH resistance in chronic renal failure.

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Changes in serum insulin-like growth factor binding protein-2, -3, and -6 levels in patients with chronic renal failure following renal transplantation

Cited by 7 publications

References 22 publications

Circulating levels of human insulin‐like growth factor binding protein‐6 (IGFBP‐6) in health and disease as determined by radioimmunoassay

Circulating levels of human insulin‐like growth factor binding protein‐6 (IGFBP‐6) in health and disease as determined by radioimmunoassay

The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients

Acromegaly and end-stage renal disease: A diagnostic challenge

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