Changes in Serum Glutamic Oxalacetic Transaminase in Patients With Diseases of the Heart, Liver or Musculoskeletal Systems

Moore, Charles B.; Birchall, Robert; Horack, Harold Maclachlan; Batson, Hugh M.

doi:10.1097/00000441-195711000-00004

Cited by 19 publications

(3 citation statements)

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“…Moreover, not all signs and symptoms of pesticide poisoning are present in every patient . In some cases, the markers used to monitor pesticide intoxication are subject to flux as a result of other bodily conditions …”

Section: Introductionmentioning

confidence: 99%

Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry

Lee

Chen

et al. 2016

J. Mass Spectrom.

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Self-poisoning with pesticides accounts for approximately one-third of all suicides worldwide. To expedite rescue in the emergency department, it is essential to develop a point-of-care analytical method for rapid identification of ingested pesticides. In this study, five of the most common pesticides ingested by self-poisoning patients in Taiwan were analyzed from oral fluid samples. Pesticide-oral fluid mixtures were applied on a cotton swab and then transferred into methanol. A metallic probe was used to sample the methanol solution for subsequent thermal desorption-electrospray ionization mass spectrometry analysis. Altogether, pesticide sampling, transfer, desorption, ionization, and detection took less than 1 min. The reproducibility of this method (n = 6) was shown in the observed low-relative standard deviation (<7%) in the detection of pesticide in oral fluid. The detection limits of the pesticides in oral fluid obtained from four human subjects by thermal desorption-electrospray ionization mass spectrometry were between 1-10 ppb with relative standard deviation 10.7%. Moreover, in this study, linear responses of five pesticides in oral fluid with concentrations between 1 ppb-1 ppm (R2 between 0.9938 and 0.9988) were observed. As the whole analytical process is extremely short, this technique allows for early non-invasive point-of-care identification of pesticides in the oral fluid of self-poisoning patients in the emergency room, providing important toxicological information for decision-making during critical resuscitation.

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Section: Introductionmentioning

confidence: 99%

Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry

Lee

Chen

et al. 2016

J. Mass Spectrom.

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“…The result is z = 17. 7. This z appears in table VII as z13, the subscripts indicating which enzymes are concerned.…”

Section: Examplementioning

confidence: 99%

Statistical Characteristics and Normal Values of Four Serum Enzymes, Glutamic Oxalacetic Transaminase, Glutamic Pyruvic Transaminase, Aldolase, and Creatine Phosphokinase

Shaw¹,

Pearson²,

Chowdhury³

1966

Enzymol Biol Clin

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Levels of glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), aldolase (ALD), and creatine phosphokinase (CPK) have been measured in healthy subjects. No effect of age has been found, but there is a sex difference. Males have higher levels than females. Except for GOT and GPT none of the enzymes show correlated levels. The logarithm of enzyme level is found to be better than the original value for statistical purposes. Confidence intervals for normal values are given for each enzyme. A method of evaluating the joint significance of the results of one, two, three, or four enzymes is given. The values are combined into a single index, high levels of which indicate hyperenzymemia. A simple procedure for the statistical assessment of a given result is provided in table VII and figure 4.

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“…Moore et al [5] have found that serum acetylcholinesterase (ACE) is reduced in acute myocardial infarction (AMI), in contrast to the increased activity of serum creatine kinase (CK). The mechanism and the clinical importance of the increased CK level in AMI were studied extensively during the last two decades 0300-9130/82/0181/0181/$ 1.40 [2,4,6,11], for the diagnosis and the d e t e r m i n a t i o n of the infarct size, but no r e p o r t has b e e n p u b l i s h e d since 1957 on the i m p o r t a n c e of the r e d u c e d A C E for the diagnosis a n d / o r prognosis of the A M I .…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of serum acetylcholinesterase in myocardial infarction

et al. 1982

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The aim of the present work was to determine experimentally the prognostic value of reduced activity of serum acetylcholinesterase (ACE) in cases of acute myocardial infarction (AMI). In the first part of the research we studied the mechanism of this reduction by comparing the serum results with the levels of the enzyme in cardiac tissue in such cases. It was found that ACE activity is reduced in serum and also in cardiac tissue in AMI, in contrast to creatine kinase (CK) that is augmented in serum but reduced in cardiac tissue. This fact was interpreted as a "reduced cardiac flow of ACE," in contrast to the "augmented cardiac clearance of CK" in similar cases. In the second part of our research, 50 patients, admitted in our hospital for AMI, were examined and their blood analysed mainly for ACE and CK at brief intervals (every 2-3 days), during hospitalization, and thereafter every 1-2 weeks for 1-4 months. From the results of ACE activity it was possible to classify these variations into four groups, each of them having a defined prognostic value for the evolution of the AMI, a persistent reduced serum activity being interpreted as a bad, severe prognosis, with high morbidity or mortality (groups II and III). We suggest, therefore, that the determination of ACE in serum in cases of AMI, especially before discharge home of such patients, may be an additional useful laboratory test in such cases.

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Changes in Serum Glutamic Oxalacetic Transaminase in Patients With Diseases of the Heart, Liver or Musculoskeletal Systems

Cited by 19 publications

References 0 publications

Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry

Rapid identification of pesticides in human oral fluid for emergency management by thermal desorption electrospray ionization/mass spectrometry

Statistical Characteristics and Normal Values of Four Serum Enzymes, Glutamic Oxalacetic Transaminase, Glutamic Pyruvic Transaminase, Aldolase, and Creatine Phosphokinase

The prognostic value of serum acetylcholinesterase in myocardial infarction

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