Changes in serum enzyme levels after exercise in trained and untrained subjects

Abstract

Twenty-eight healthy trained and untrained men and eleven untrained women were exercised at several grades on a treadmill or in various athletic events. The serum levels of five enzymes (two transaminases, aldolase, and two dehydrogenases) were compared prior to and at intervals after work. Generally there was a rise after exercise which reached its peak 5 min after completion of the work. The greatest increment of enzyme increase was observed in the untrained subjects and the least in the trained athletes. As the total amount of work output increased the mean serum enzyme levels were correspondingly raised. Aldolase and lactic dehydrogenase showed the least change, malic dehydrogenase increased moderately, while the two transaminases manifested very significant rises after all forms of exercise. Submitted on September 5, 1961

Effect of Routine Treadmill Testing on the Serum Enzymes

“…The analyses of our data in relation to conditioning may falsely appear to antagonize the currently accepted observation that physical training will result in lesser enzyme changes following exercise [5,11,18]. How ever, the higher increments in SGOT and CPK immediately after exercise in the physically active group can be accounted for by the longer duration of mean exercise time, 9'23", compared to 4'4" in the sedentary group.…”

“…Analyses of the data in relation to the presence or absence of ischemic ST shifts and presence or absence of documented coronary obstruction, failed to show any significant correlation. The effect of con ditioning on the serum enzyme changes postexercise was not demonstrable.A number of serum enzymes are known to increase following vigorous exercise [5,11], Several studies have shown elevation of serum glutamic oxalacetic transaminase (SGOT), creatine phosphokinase (CPK), and lactic dehydrogenase (LDH) to the abnormal range following a variety of exercise protocols [12,15,17]. However, we could not find any in formation regarding serum enzyme levels following routine treadmill test ing.…”

Statistical Characteristics and Normal Values of Four Serum Enzymes, Glutamic Oxalacetic Transaminase, Glutamic Pyruvic Transaminase, Aldolase, and Creatine Phosphokinase

“…However, the exact reason for this is not evident. It is known that even moderate exercise raises the levels of both GOT and GPT [3]. Some of the subjects may have exercised sufficiently just before venipuncture to increase the levels.…”

Effects of age, training and exercise on plasma lactate dehydrogenase activity in male rats

“…The use of treadmill running as a test exercise by Fowler et al (1962) resulted in increases in serum LDH only when the incline of the treadmill was set at 11 degrees. Other serum enzyme activities increased significantly at less strenuous levels of exercise.…”

“…In humans, exercise has resulted in increased plasma enzyme activi ties, while physical training has reduced the elevation of plasma enzyme activities due to exercise (Cantone and Cerretelli, 1960;Fowler et al, 1962;Hunter and Critz, 1971;and Wolfson et , 1972). Studies with experimental animals have usually resulted in similar findings (Sangster and Beaton, 1966;Novosadova, 1969;Highman and Altland, 1963;and Papadopoulos et , 1968).…”