Changes in serum cytokine concentrations after neurosurgical procedures

Osuka, Koji; Suzuki, Yoshio; Saito, Kiyoshi; Takayasu, Misako; Shibuya, Masabumi

doi:10.1007/bf01411287

Cited by 20 publications

(15 citation statements)

References 27 publications

(16 reference statements)

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“…In neutrophils, activation of p38MAPK stimulated by IL-1 is followed by increased expression of CD11b ( 2 integrin) and CD15 (P-selectin ligand) that directly enhances ROS production [39]. Hemorrhagic and ischemic stroke may both result in the increase of cytokines concentration in the peripheral vessels [43,44], but there are also papers not confirming this effect [45,46]. Ferrarese, however, showed stimulation of peripheral leukocytes, manifesting by increase in cytokines release in culture, without an increase of their concentration in the plasma [47].…”

Section: Discussionmentioning

confidence: 96%

Interleukin-1&bgr; Increases Release of Endothelin-1 and Tumor Necrosis Factor as Well as Reactive Oxygen Species by Peripheral Leukocytes During Experimental Subarachnoid Hemorrhage

Larysz‐Brysz

Lewin–Kowalik²,

Czuba³

et al. 2012

CNR

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In the subarachnoid hemorrhage (SAH) blood mixes with cerebrospinal fluid, what starts immunoinflammatory processes - increased synthesis of proinflammatory cytokines, and formation of reactive oxygen species (ROS), resulting in pre-activation of different populations of peripheral leukocytes. Migration of leukocytes to the brain parenchyma through broken blood brain barrier may produce extra brain tissue injury besides of that resulting from SAH. We examined in adult rats the effect of interleukin-1β (IL-1β) neutralization on secretion of cytokines as well as production of ROS in the course of SAH. SAH was produced by injection of 150 μL of autologous arterial blood into cisterna magna. In 50% of animals, IL-1beta activity was inhibited by intracerebroventricular administration of anti-rat IL-1β antibodies. Ninety minutes or 24 hrs following surgery, blood samples were drawn from the extraorbital plexus and centrifuged to obtain two leukocyte subpopulations - polymorphonuclear (PMN) and mononuclear (MN). The chemiluminescence, a hallmark of ROS synthesis, was measured in PMNs. In supernatants from MNs cultures, concentrations endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were assessed. SAH caused the increase ofn PMNs chemiluminescence as well as the increase of production of ET-1 and TNF-α by MNs but had no influence on IL-6 concentration. Neutralization of IL-1β resulted in significant decrease of chemiluminescence as well as concentration of both ET-1 and TNF-α, while IL-6 concentration was increased. These revealed an important role of IL-1β in the activation of peripheral leukocytes in the course of subarachnoid hemorrhage.

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Section: Discussionmentioning

confidence: 96%

Interleukin-1&bgr; Increases Release of Endothelin-1 and Tumor Necrosis Factor as Well as Reactive Oxygen Species by Peripheral Leukocytes During Experimental Subarachnoid Hemorrhage

Larysz‐Brysz

Lewin–Kowalik²,

Czuba³

et al. 2012

CNR

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“…Several cells secrete multiple posttranslationally modified forms of IL-6: keratinocytes (43), skeletal muscle cells (44), endothelial cells (45), neurons, microglia, and astrocytes (13)(14)(15). Elevated levels of IL-6 or a defined IL-6 promoter polymorphism are observed in human body fluids during acute and chronic infections (16,20), Kaposi's sarcoma (46,47) and other neoplasia (48 -50), autoimmune diseases (24,(27)(28)(29)(30)(31), endometriosis (51), after third-degree burns (22,43), strenuous exercise (IL-6 concentration increases as much as 100-fold after a marathon) (44) major surgery (17)(18)(19), and ABI (1-7).…”

Section: Discussionmentioning

confidence: 99%

“…Systemic IL-6 is elevated 4 hrs after neurosurgical procedures (18,19) and in children with ABI (1). In a previous study, elevated IL-6 was found in adults with brain death diagnosis (52).…”

Section: Discussionmentioning

confidence: 99%

“…High IL-6 concentrations can be detected in a series of diseases and clinical syndromes. Among these are the systemic inflammatory response syndrome (16), major surgery (17)(18)(19), sepsis (20), response to multiple trauma (21), and severe burns (22). It is considered that IL-6 is perhaps the most important mediator of acute phase synthesis (23), and once IL-6 is released from the inflammatory focus, it induces a wide range of systemic effects (13)(14)(15).…”

mentioning

confidence: 99%

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Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury

Miñambres

Cemborain

Sánchez-Velasco

et al. 2003

Critical Care Medicine

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IL-6 is elevated in patients with acute brain injury, and a significant relationship exits between the severity of acute brain injury and the transcranial IL-6 gradient at admission. It can be considered to be a prognosis marker at admission. When data at the moment of brain death are considered, venous IL-6 (p <.01) and the transcranial IL-6 gradient (p <.005) are significantly higher than at the time of admission. Although the IL-6 C allele is associated with significantly lower concentrations of IL-6, there was no correlation between low or high IL-6 responders and patient outcome.

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“…Protein expression is similarly increased within 1-5 h of injury, peaking by 3-8 h [19,22,24,[26][27][28][29]. In the clinical setting elevated levels of blood or CSF TNF [30][31][32][33][34][35], IL-1 [34][35][36] and IL-6 [32][33][34][37][38][39][40][41][42][43][44] have been reported in patients following both TBI and nontrauma associated craniotomy.…”

Section: Leucocyte Recruitment Following Traumatic Brain Injurymentioning

confidence: 98%