Changes in serum concentration of 17 beta-estradiol in female rats during estrous cycle after treatment with atrazine and zearalenone

Mitak, Mario; Gojmerac, Tihomira; Mandić, Božica; Cvetnić, Željko

doi:10.17221/7868-vetmed

Cited by 13 publications

(7 citation statements)

References 13 publications

(8 reference statements)

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“…In our experiment, there were no observed effects of 1.11 mg ZEN/kg diet on E2 or TS. This finding differed from those of Mitak et al (2001), who reported E2 content was increased in female rats subjected to oral ZEN administration (2.5 mg/d) during the rutting period. Berger et al (1981) reported that ZEN consumption (40 mg/kg) results in depressed plasma TS in prepubertal boars.…”

Section: Discussioncontrasting

confidence: 99%

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

Chen

Hou

et al. 2015

Italian Journal of Animal Science

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The experiment was conducted to investigate alleviative effects of modified maifanite (MMF) on zearalenone (ZEN) toxicity in female weaner pigs. In this experiment, 32 female weaner pigs (Duroc×Landrace×Large white, 10.50±0.07 kg) were divided into 4 groups (8 pigs/group): control group (0.02 mg/kg ZEN); ZEN-treated group (1.11 mg/kg ZEN); MMF-treated group (1% MMF); ZEN+MMF treated group (1.11 mg/kg ZEN and 1% MMF), The trial period lasted for 28 d. Growth performance, vulva size, genital organs, antioxidant enzyme activities, serum metabolites and ZEN residues in female weaner pigs were determined. The results showed that the treatments had no effect on growth performance and length and width of the vulva. However, vulva area (P=0.038) and progesterone (P=0.022) were affected by the ZEN×MMF interaction. Treatment with ZEN resulted in a significant increase of the genital organ weight (P=0.002) and decrease of serum superoxide dismutase (P=0.017) activity. Feeding of the ZEN diet decreased the number of red blood cells (P=0.009) and platelets (P=0.002). The MMF reduced methane dicarboxylic aldehyde concentration when fed with ZEN diet but not when fed with the basal diet (ZEN×MMF, P=0.018). In the liver, feeding of the ZEN diet with MMF reduced the levels of ZEN residues (P=0.003). Our findings suggest that the addition of MMF to ZEN diet resulted in partial restoration of antioxidant status and reduced ZEN levels in the liver.

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Section: Discussioncontrasting

confidence: 99%

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

Chen

Hou

et al. 2015

Italian Journal of Animal Science

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“…(a) Each bar represents the mean ± SEM of three replicates from three independent experiments. The measured estradiol levels were within the reference range [24]. Specific calibration curves and appropriate positive/negative controls were carried out during the assay.…”

Section: Figurementioning

confidence: 99%

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age‐Associated Damage

Pozzo

Costa

Cavallini

et al. 2017

Oxidative Medicine and Cellular Longevity

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In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. These results suggested that naringenin has antiaging effects on myocardial cells.

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“…Zearalenone could induce hyperestrogenism in pigs, with typical clinical symptoms including swollen vulva ( Alexopoulos, 2001 ), vaginal prolapsed ( Blaney et al, 1984 ), as well as reproductive disorders such as infertility, miscarriage and false estrus in sows ( Etienne and Jemmali, 1982 ; Price et al, 1993 ). Notwithstanding, the effects of ZEA on endocrine disturbance, morphology and apoptosis of reproductive organs had been well established in sows ( Chang et al, 1979 ; Yang et al, 1994), experimental animals ( Milano et al, 1995 ; Kaliamurthy et al, 1997 ; Mitak et al, 2001 ) and cultured cells ( Tiemann et al, 2003 ). We found the manifest effect of ZEA on post-weaning piglets during clinical practice and therefore the studies were performed using post-weaning gilts.…”

Section: Introductionmentioning

confidence: 99%

Zearalenone Altered the Serum Hormones, Morphologic and Apoptotic Measurements of Genital Organs in Post-weaning Gilts

Chen

Yang

Huang

et al. 2014

Asian Australas. J. Anim. Sci

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The present study was aimed at investigating the adverse effects of dietary zearalenone (ZEA) (1.1 to 3.2 mg/kg diet) on serum hormones, morphologic and apoptotic measurements of genital organs in post-weaning gilts. A total of twenty gilts (Landrace×Yorkshire×Duroc) weaned at 21 d with an average body weight of 10.36±1.21 kg were used in the study. Gilts were fed a basal diet with an addition of 0, 1.1, 2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum. Results showed that 3.2 mg/kg ZEA challenged gilts decreased (p<0.05) the serum levels of luteinizing hormone, however, serum levels of prolactin in gilts fed the diet containing 2.0 mg/kg ZEA or more were increased (p<0.05) compared to those in the control. Linear effects on all tested serum hormones except progesterone were observed as dietary ZEA levels increased (p<0.05). Gilts fed ZEA-contaminated diet showed increase (p<0.05) in genital organs size, hyperplasia of submucosal smooth muscles in the corpus uteri in a dose-dependent manner. However, the decreased numbers of follicles in the cortex and apoptotic cells in the ovarian were observed in gilts treated with ZEA in a dose-dependent manner. Degeneration and structural abnormalities of genital organs tissues were also observed in the gilts fed diet containing 1.1 mg/kg ZEA or more. Results suggested that dietary ZEA at 1.1 to 3.2 mg/kg can induce endocrine disturbance and damage genital organs in post-weaning gilts.

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Changes in serum concentration of 17 beta-estradiol in female rats during estrous cycle after treatment with atrazine and zearalenone

Cited by 13 publications

References 13 publications

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age‐Associated Damage

Zearalenone Altered the Serum Hormones, Morphologic and Apoptotic Measurements of Genital Organs in Post-weaning Gilts

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