Changes in Serum Calcium, Inorganic Phosphate and Phosphatase Activity in the Pregnant Woman

Bodansky, Meyer

doi:10.1093/ajcp/9.1.36

Cited by 37 publications

(6 citation statements)

References 5 publications

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“…Although standard texts still suggest that pregnancy does not alter hepatic function in humans, elevation of serum levels of alkaline phosphatase is common during the last trimester (37)(38)(39)(40) (6). The results of the present study are consistent with this view and indicate that estrogens in particular may account wholly, or in part, for the maternal hepatic functional alterations described.…”

Section: Discussionsupporting

confidence: 84%

Estrogen Pharmacology. I. The Influence of Estradiol and Estriol on Hepatic Disposal of Sulfobromophthalein (BSP) in Man*

Mueller¹,

Kappas²

1964

J. Clin. Invest.

137

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This report 1 describes the influence of natural estrogens on liver function, with special reference to sulfobromophthalein (BSP) excretion, in man. Pharmacological amounts of the hormone estradiol consistently induced alterations in BSP disposal that were shown, through the techniques of Wheeler and associates (2, 3), to result from profound depression of the hepatic secretory transport maximum (Tm) for the dye. Chromatographic analysis of plasma BSP components revealed increased amounts of BSP conjugates during estrogen as compared with control periods, implying a hormonal effect on cellular processes concerned with transport of dye from hepatocytes into biliary canaliculi. Estriol, an in vivo transformation product of estradiol, also impaired hepatic disposal of BSP in man. According to unpublished data of Hertz (4) 2 estrone, ethinyl estradiol, and equine estrogens act similarly, and it is likely that other C-18 steroids of both physiologic and synthetic origin have this property as well. These observations define a new * Submitted for publication April 13, 1964; accepted June 16, 1964. biological action of natural estrogens in man, further substantiate the role of the liver as a site of action of these hormones (5), and probably account, in part, for the impairment of BSP disposal that characterizes pregnancy (6) and the neonatal period (7-10). MethodsSteroid solutions were prepared by dissolving crystalline estradiol and estriol in a solvent vehicle containing 10% N,NDMA (N,N-dimethylacetamide) 3 in propylene glycol. Estradiol was soluble in a concentration of 100 mg per ml; estriol, in a concentration of 20 mg per ml. These, together with appropriate control solutions, were sterilized by filtration at room temperature and administered to patients by intramuscular injection. All subjects were housed on a metabolic ward during the study, and a number were maintained on fixed diets as required by concurrent investigations. The principal clinical diagnoses were rheumatoid arthritis and related connective tissue disorders. The observations reported here were made during a series of studies designed initially to examine the potential use of pharmacological amounts of natural estrogens as therapeutic or immunosuppressive (11)(12)(13) agents in man; the periods of estrogen administration therefore varied considerably from subj ect to subject. Liver function was examined in these patients by the following tests: per cent esterification of cholesterol, direct and indirect bilirubin, cephalin and thymol flocculations, thymol turbidity, prothrombin time, serum albumin and globulin, retention of BSP in plasma 45 minutes after intravenous administration of 5 mg per kg body weight, and the following serum enzymes: alkaline phosphatase, lactic dehydrogenase (LDH), glutamic pyruvic transaminase (SGPT), and glutamic oxaloacetic transaminase (SGOT). BSP infusion studies, chromatography of plasma BSP components, and liver biopsies were performed in several subjects as described below.Thirty-one patients were treated wit...

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Section: Discussionsupporting

confidence: 84%

Estrogen Pharmacology. I. The Influence of Estradiol and Estriol on Hepatic Disposal of Sulfobromophthalein (BSP) in Man*

Mueller¹,

Kappas²

1964

J. Clin. Invest.

137

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“…( 2 ) que, em estudos fei tos na mulher, observaram elevação na atividade da fosfatase sé-rica, sobretudo a partir do 7" mês de gestação, admitindo que tal elevação esteja relacionada com o aumento do metabolismo ósseo da gestante. Rev.…”

Section: Animelunclassified

“…8 fase. 2,1970 M e r a n z e e cols., citados por B o d a n s k y e cols. ( 2 ) , admitem que a elevação na atividade dessa enzima durante a gestação coin cida com o período de maior ossificação fetal.…”

Section: Animelunclassified

“…2,1970 M e r a n z e e cols., citados por B o d a n s k y e cols. ( 2 ) , admitem que a elevação na atividade dessa enzima durante a gestação coin cida com o período de maior ossificação fetal. Não podendo o fe to, nessa ocasião, elaborar maior quantidade de fosfatase, a taxa adicional necessária seria produzida pelo organismo materno, sen do, assim, supridas as necessidades fetais.…”

Section: Animelunclassified

“…B o d a n s k y e Ja f f e , citados por B o d a n s k y e cols. ( 2 ) , lança ram o conceito da reatividade específica controlada para reabsor ção óssea, traduzida pela velocidade com que os minerais seriam retirados e, em seguida, novamente depositados nos ossos. A fos fatase sérica representaria, nestas condições, um reflexo dessa rea tividade específica.…”

Section: Animelunclassified

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Níveis sanguíneos de transaminase glautâmico pirúvica, transaminase glutâmico oxaloacética, fosfatases ácida e alcalina e amilase, durante a prenhez e o pós-parto da égua puro sangue inglês

Bizutti

Neto

Oliveira

et al. 1970

Rev. Fac. Med. Vet.

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O. INTRO D U ÇÃOModificações nos níveis normais das enzimas são atualmente de valor, não só para orientação do clínico em uma série de doen ças, como também para o reconhecimento de certos desvios meta bólicos.Isto decorre do fato, já descrito, de que as variações nos teores normais das enzimas presentes no sôro podem manifestar-se, quer por desequilíbrio bioquímico ao nível da célula, como sói acontecer, exemplificando, nas alterações da permeabilidade celular.Tendo em mira as possíveis modificações metabólicas presen tes durante a gestação, procurou-se analisar neste trabalho, os ní veis séricos das seguintes enzimas: transaminase glutâmico pirú-vica (S G P -T ), transaminase glutâmico-oxalacética (SG O -T), fosfatase alcalina, fosfatase ácida e amilase, durante a prenhez da égua puro sangue inglês (p. s. i).L IT E R A T U R A A literatura existente, não só quanto ao objetivo ora proposto como também no que tange a espécie animal referida, é reduzida, muito embora seja extensa a bibliografia concernente aos teores séricos de determinadas enzimas em diferentes espécies animais 446 Rev.

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Regulation of the Level of Calcium in the Serum During Pregnancy

Bodansky¹,

Duff²

1939

JAMA

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Changes in Serum Calcium, Inorganic Phosphate and Phosphatase Activity in the Pregnant Woman

Cited by 37 publications

References 5 publications

Estrogen Pharmacology. I. The Influence of Estradiol and Estriol on Hepatic Disposal of Sulfobromophthalein (BSP) in Man*

Estrogen Pharmacology. I. The Influence of Estradiol and Estriol on Hepatic Disposal of Sulfobromophthalein (BSP) in Man*

Níveis sanguíneos de transaminase glautâmico pirúvica, transaminase glutâmico oxaloacética, fosfatases ácida e alcalina e amilase, durante a prenhez e o pós-parto da égua puro sangue inglês

Regulation of the Level of Calcium in the Serum During Pregnancy

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