Changes in Serum Calcium and Serum Magnesium Level in Preeclamptic vs Normal Pregnancy

Chaurasia, Pallavi; Jadav, Pranay; Jasani, Jasmin

doi:10.7439/ijbar.v3i6.508

Cited by 14 publications

(24 citation statements)

References 12 publications

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“…The Mean ± SD of gestational ages of the preeclamptic women and the normal healthy women are significantly different as is shown in Table 1. The present study showed a Mean ± SD of 36.38 ± 4.19 weeks in cases and 39.62 ± 1.16 weeks in controls with a highly significant p-value of < 0.001, which correlates with the study of Deepa V Kanagal et al (8) and of Harma et al, (9) Farah Saleh et al (10) and Chaurasia et al (11) Mean ± SD of systolic BP (153±19.39 mmHg vs. 109.6±7.55 mmHg) and Mean ± SD of Diastolic BP (102.4±13.99 mmHg vs. 75.4±5.30 mmHg) of the preeclamptic group are significantly higher than the control group (p < 0.001) as shown in Table 2, which correlates well with the study of Rubina Aziz et al (12) and also with the study of Deepa V Kanagal et al (8) and Farah Saleh et al (10)…”

Section: Discussionsupporting

confidence: 91%

Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

Anusha¹,

Sankaranarayana²

2018

jemds

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BACKGROUND The lowering of serum calcium can cause an elevation of blood pressure in pre-eclamptic mothers. Magnesium is a potent vasodilator of uterine and mesenteric arteries and aorta. Magnesium also increases NO production causing vasodilation. Elevation of uric acid in preeclampsia is due to factors such as abnormal renal clearance, increased tissue breakdown, acidosis and a rise in the activity of the xanthine oxidase/ dehydrogenase enzyme. In preeclampsia hypervascularisation and vasoconstriction of liver leads to liver cell injury and alteration of cell membrane permeability and damage to the cells which allows intracellular enzymes to leak into the blood leading to elevated liver enzymes like AST, ALT and Alkaline phosphatase. Aims and Objectives of the Study-To estimate and compare the levels of serum calcium, magnesium, uric acid and liver enzymes in women with preeclampsia and normal pregnant women. MATERIALS AND METHODS This case control study was conducted at GGH, Vijayawada, Andhra Pradesh. Data was collected from 50 preeclampsia cases and 50 normal healthy pregnancies in the Department of Obstetrics and Gynaecology. RESULTS Mean Gestational age showed high significance with mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a 'p' value of < 0.001. Systolic BP (150.4 ± 19.37 mmHg vs. 109.6 ± 7.55 mmHg) and mean ± SD of Diastolic BP (100.6 ± 14.05 mmHg vs. 75.4 ± 5.30 mmHg) of the pre-eclamptic group are significantly higher than the control group. Value of calcium in pre-eclamptic women was significantly low (8.57 ± 0.96 mg/dL vs. 9.88 ± 1.38 mg/dL; p < 0.001). Magnesium in preeclamptic women was lower than normal pregnant women (1.92 ± 0.36 mg/dL vs. 2.26 ± 0.25 mg/dL; p < 0.001). The serum uric acid in pre-eclamptic women was significantly more than normal pregnant women (6.66 ± 2.21 mg/dL vs. 4.51 ± 1.18 mg/dL, p < 0.001). ALP, AST and ALT were increased in cases compared to controls and are statistically highly significant (p < 0.001). CONCLUSION Based on the present study, serum calcium and magnesium levels are low in pre-eclamptic mothers. Pregnant women should be educated about nutrition during pregnancy and probable risks of inappropriate diet should be informed. Thus, it can be concluded that Calcium and Magnesium can be evaluated at an early date, so that such mineral deficiencies can be treated by appropriate Calcium and Magnesium supplements. Uric acid and Liver enzymes can possibly be used as biomarkers for identifying and avoiding adverse pregnancy outcomes by prompt intervention.

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Section: Discussionsupporting

confidence: 91%

Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

Anusha¹,

Sankaranarayana²

2018

jemds

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“…The mean serum calcium did not differ significantly between the subjects of pre-eclampsia and normal pregnant women (p=0.963). This was in contrast with several studies, 5,6,[13][14][15] suggesting hypocalcemia as a possible cause for preeclampsia. All theses study reported significantly lower calcium in pre-eclamptic patients than normal pregnancy.…”

Section: Discussioncontrasting

confidence: 99%

“…So the modification of calcium metabolism during pregnancy could be one of the causes of pre-eclampsia [10][11] . Several studies showed that significantly low serum calcium level in pre-eclamptic women as compare to normal pregnant (p<0.05) [12][13][14][15][16] . But in other studies serum levels of calcium did not differ significantly between pre-eclamptics and comparative group 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Calcium Levels in Pre-eclampsia

et al. 2018

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Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum calcium level are found associated with elevated blood pressure in preeclampsia. To evaluate serum calcium level in pre-eclamptic women. This cross sectional study was carried out in among 50 preeclamptic patients, aged 20 to 40 years, and gestational age ranges from 20 to 40 weeks and 50 age and gestational age matched normotensive pregnant women having no proteinuria. Serum calcium was measured by Colorimetric method. The mean age and mean gestational age of pre-eclampsia was not significantly different from those of normotensive pregnant women (p=0.203 and p=0.251 respectively). The mean body mass indexes of the test patients were significantly different from those of normotensive pregnant women (p<0.001). The mean serum calcium level was 7.27 ± 3.01 mg/dl in pre-eclampsia and 7.25 ± 2.59 mg/dl in normal pregnant women; did not differ significantly between the subjects of pre-eclampsia and normal pregnant women (p=0.963). Serum calcium has no association in occurrence of preeclampsia.

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“…sodium potassium ATPase) and involved in peripheral vasodilatation. 2,9,10 Some studies shows that blood calcium and magnesium have a relaxant effect on the blood vessels of pregnant women. 9,11 Aims and objectives…”

Section: Introductionmentioning

confidence: 99%

Comparison of serum calcium and magnesium levels between preeclamptic and normotensive healthy pregnant women

Mittal

Shaikh

Thakur

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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Changes in Serum Calcium and Serum Magnesium Level in Preeclamptic vs Normal Pregnancy

Cited by 14 publications

References 12 publications

Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

Evaluation of Serum Calcium Levels in Pre-eclampsia

Comparison of serum calcium and magnesium levels between preeclamptic and normotensive healthy pregnant women

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