Changes in serum C-reactive protein levels in dogs with various disorders and surgical traumas

Abstract

The serum levels of C-reactive protein (CRP) produced as an inflammatory response in dogs with various disorders and surgical traumas were measured by enzyme-linked immunoabsorbent assay and slide reversed passive latex agglutination test (RPLA). The CRP levels were greatly increased 1-2 days after surgery in most of the dogs (n = 29) subjected to surgery. These levels had markedly decreased by the time the sutures were removed. In dogs with various disorders (n = 58), the serum CRP levels at first diagnosis were high in infectious diseases. In dogs from which paired serum samples were examined, the serum CRP usually showed a decrease with improvement in the condition (n = 11) or a terminal increase (n = 4) but, conversely, some showed an increase with improvement in the condition (n = 3).

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

“…Macroscopically, it seems that the surgical procedure for spinal decompression is much more traumatic than an ovariohysterectomy and that this should be reflected by higher CRP concentrations. CRP values were found to increase much more in orthopaedic surgery compared with ovariohysterectomy in 1 study, and the authors concluded that the rise in CRP was indeed proportional to the intensity of surgical trauma 29 . Another, larger study found the opposite, with the median CRP concentration 24 hours postoperatively being higher in dogs undergoing ovariohysterectomy than in dogs undergoing orthopaedic procedures 9 .…”

“…These proteins are integral to the acute phase response, which is the body's rapid initial systemic inflammatory reaction to any non-specific tissue injury 10,13,24,29 . Examples of other acute phase proteins are fibrinogen, serum amyloid A, haptoglobin and ceruloplasmin.…”

“…The synthesis of positive APPs is stimulated by various proinflammatory cytokines in response to tissue injury or infection. The main stimulatory cytokines are interleukin-1, interleukin-6 and tumour necrosis factor alpha 10,15,24,29 . The exact functions of the APPs are not completely understood, but it is known that they regulate and coordinate the body's response to tissue injury.…”

Plasma High-Mobility Group Box 1 (HMGB1) in Dogs with Various Diseases: Comparison with C-Reactive Protein

“…Blood CRP concentration is increased in various inflammatory diseases [9,30,16], and its increased level is correlated with the severity and course of the diseases [9,29]. Although few reports are available on blood HMGB1 levels in diseased dogs [13,32], Yu et al recently reported increased plasma HMGB1 levels in dogs with systemic inflammatory response syndrome (SIRS) [32].…”

Acute Phase Proteins – Analysis, Clinical Applications and Potentials

“…CRP is a major APP in dogs and its serum concentration can increase rapidly from <1mg/L to >100 mg/L in a number of conditions including surgical trauma, rheumatoid arthritis, polyarthritis, intestinal obstruction, inflammatory bowel disease, lymphoma, acute pancreatitis, pyometra, pneumonia, bacterial enteritis, turpentine oil injection, E.coli endotoxemia, babesiosis, leishmaniosis, leptospirosis, parvovirus infection, trypanosomiasis, Bordetella bronchiseptica and B.canis and Ehrlichia canis infection, bacterial and hemorrhagic enteritis and tumors Jergens et al, 2003and Tecles et al, 2005, Yamamoto, et al, 1993. CRP levels increase from mid-gestation in pregnant bitches, coinciding with embryonic implantation (Eckersall et al, 1993;Vannucchi et al, 2002).…”