Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs

Rubio, Camila Peres; Martı́nez-Subiela, Silvia; Tvarijonaviciute, Asta; Hernández‐Ruíz, Josefa; Pardo-Marín, Luis; Segarra, Sergi; Cerón, José J.

doi:10.1016/j.cimid.2016.09.003

Cited by 22 publications

(15 citation statements)

References 32 publications

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“…The ELISA used for quantitative determination of adrenaline (epinephrine) (Adrenaline Research ELISA™) had intra-assay and inter-assay variability less than 10% and a limit of detection of 0.25 ng/ml. Total oxidant status, paraoxonase 1 (PON1) and total antioxidant capacity (TAC; measured by trolox equivalent antioxidant capacity) were analysed following published methods [27][28][29]. All determinations of oxidative stress biomarkers were performed in an automated biochemistry analyser (Olympus AU600 Automatic Chemistry Analyzer, Olympus Europe GmbH, Germany).…”

Section: Plos Onementioning

confidence: 99%

Assessment of laying-bird welfare following acaricidal treatment of a commercial flock naturally infested with the poultry red mite (Dermanyssus gallinae)

et al. 2020

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The poultry red mite (PRM), Dermanyssus gallinae, a potential vector of pathogens to animals and humans, causes impaired bird welfare. A study investigated changes in behavioural variables, physiological biomarkers, and health parameters following acaricidal treatment of PRM infestation of laying hens on a commercial farm. Mite traps determined the challenge to 12,700 hens before and after drinking water administration of the acaricide, fluralaner (Exzolt®, 0.5 mg/kg; Weeks 0 and 1). Weekly daytime direct observations and night-time video recordings monitored bird behaviours from Weeks -6 through +6. Blood samples were collected from randomly-selected birds (Weeks -6, -1, and +6). Following treatment, mite count reductions (>99%) were statistically significant (P < 0.0001), as were night-time reductions in the percent of hens showing activity, preening, head scratching (all P < 0.0001), and head shaking (P = 0.0007). Significant daytime reductions were observed in preening and head scratching (both P < 0.0001), head shaking (P = 0.0389), severe feather pecking (P = 0.0002), and aggressive behaviour (P = 0.0165). Post-treatment, comb wounds were significantly reduced (P = 0.0127), and comb colour was significantly improved (P < 0.0001). Heterophil/lymphocyte ratio was significantly reduced at Weeks 1 and 6 (P = 0.0009 and P < 0.0001, respectively). At Week 6, blood corticosterone (P = 0.0041) and total oxidant status (P < 0.0001) were significantly reduced, and haemoglobin and mean corpuscular haemoglobin significantly increased (P < 0.0001). Farm production records indicated that those post-treatment improvements were accompanied by significant reductions in weekly mortality rate (P = 0.0169), and significant recovery in mean weekly egg weights (P < 0.0001) and laying rate (P < 0.0001). The improvements in behavioural variables, physiological biomarkers, and health parameters that were observed following the elimination of PRM on a commercial farm indicate that infestations can be a cause of reduced hen welfare.

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Section: Plos Onementioning

confidence: 99%

Assessment of laying-bird welfare following acaricidal treatment of a commercial flock naturally infested with the poultry red mite (Dermanyssus gallinae)

et al. 2020

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“…Hence, in this study a comprehensive panel of sbOS to evaluate both TAC and oxidative damage was selected. In addition, the biomarkers evaluated in the present study (CUPRAC, FRAP, FOX, PON1, TEAC‐A, TEAC‐B and THIOL) have been proven useful to evaluate involvement of OS in the pathogenesis in different chronic systemic diseases in humans, and in dogs . In dogs, OS was demonstrated by a significantly lower antioxidant capacity in dogs with clinical ehrlichiosis and leishmaniosis, when compared to healthy dogs .…”

Section: Discussionmentioning

confidence: 83%

“…Data in the veterinary literature regarding oxidative status in canine atopic diseases is limited . We used selected serum biomarkers of OS (sbOS) that have been validated in normal dogs and in dogs with different systemic chronic diseases . To the best of the authors’ knowledge, sbOS have not been described in canine AD.…”

Section: Introductionmentioning

confidence: 99%

Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis

Almela¹,

Rubio

Cerón

et al. 2018

Veterinary Dermatology

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“…The evaluation of antioxidant capacity and antioxidant enzymes in plasma were performed following the methods described in [ 31 ] Glutathione peroxidase (GPx) assay was performed based on the method described by Paglia and Valentine [ 32 ] with a commercially available kit (Ransel test kit, Randox Laboratories Ltd., Crumlin, County Antrim, UK). Catalase activity was determined according to Johansson and Borg [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Effects of Regular Consumption of Cooked Ham Enriched with Dietary Phenolics in Diet-Induced Obese Mice

et al. 2020

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Oxidative damage and chronic inflammation have been proven as one of the major factors associated with obesity, which increases the incidence of non-communicable chronic diseases. In this sense, the development of new functional products aiming at the palliation of oxidative stress and inflammatory disruption can be a determining factor for public health as seen in previous researches. In this study, a blend of potentially bioavailable dietary phenolics was added to low sodium and low-fat cooked ham. A diet-induced obesity model in C57/BL6J mice has been used for testing the effectiveness of the phenolic blend and the new functionalized product, which bioavailability was tested by UPLC-ESI-QTOF-MS. After obesity induction, different oxidative and inflammatory biomarkers were evaluated. Results in the murine induced obesity model, demonstrate a robust statistically significant improvement in key parameters related with obesity risk in the groups feed with a phenolic-enriched diets (P) + high-fat diet (HFD) and phenolic enriched cooked ham (PECH) + HFD. In both groups there was an improvement in body composition parameters, inflammatory biomarkers and antioxidant enzymes levels. Specifically in the group feed with the phenolic enriched cooked ham (PECH + HFD) there was an improvement of total fat volume (23.08% reduction), spleen index (22.04% of reduction), plasmatic MCP-1 (18% reduction), IL-6 (38.94% reduction), IL-10 (13.28% reduction), TNF-α (21.32% reduction), gut IL-1β (10.86% reduction), gut IL-6 (13.63% reduction) and GPx (60.15% increase) and catalase (91.37% increase) enzymes. Thus, the functionalized ham could be considered an appropriate dietary polyphenol source, which might improve the oxidative and inflammatory status and could finally result in the potential decrease of the risk of certain non-communicable chronic diseases.

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Changes in serum biomarkers of oxidative stress after treatment for canine leishmaniosis in sick dogs

Cited by 22 publications

References 32 publications

Assessment of laying-bird welfare following acaricidal treatment of a commercial flock naturally infested with the poultry red mite (Dermanyssus gallinae)

Assessment of laying-bird welfare following acaricidal treatment of a commercial flock naturally infested with the poultry red mite (Dermanyssus gallinae)

Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis

Anti-Inflammatory and Antioxidant Effects of Regular Consumption of Cooked Ham Enriched with Dietary Phenolics in Diet-Induced Obese Mice

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