Changes in serum albumin concentrations during transition to dialysis and subsequent risk of peritonitis after peritoneal dialysis initiation: a retrospective cohort study

Noppakun, Kajohnsak; Kasemset, Thanit; Wongsawad, Uraiwan; Ruengorn, Chidchanok; Thavorn, Kednapa; Sood, Manish M.; Nochaiwong, Surapon

doi:10.1007/s40620-020-00716-1

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Novel healthcare strategies, such as multidisciplinary care and telemedicine, are required to support these conditions. In fact, care coordination is becoming an important issue in a population suffering from multiple pathologies [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Remote monitoring in peritoneal dialysis: benefits on clinical outcomes and on quality of life

et al. 2020

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Background Automated peritoneal dialysis (APD) has been proved benefit from remote monitoring (RM), but evidences are limited. In this study, we compared clinical outcomes and quality of life (QoL) in two group of patients undergoing APD, with and without exposure of RM. Methods This is a retrospective cohort study, comparing outcomes in two groups of APD patients monitored during 6 months with RM (group A: n = 35) or standard care (group B: n = 38 patients). In our clinical practice, we assign the RM system to patients who live more distant from the PD center or difficulty in moving. We evaluated emergency visits, hospitalizations, peritonitis, overhydration, and dropout. QoL was assessed with the Kidney Disease Quality of life-Short Form (KDQOL-SF). We included four additional questions focused on patient's perception of monitoring, safety and timely problems solution (Do you think that home-therapy monitoring could interfere with your privacy? Do you think that your dialysis sessions are monitored frequently enough? Do you think that dialysis-related issues are solved timely? Do you feel comfortable carrying out your home-based therapy?). Results The case group presented a higher comorbidity score, according to Charlson Comorbidity Index (group A: 5.0; IQR 4.0-8.0 versus group B: 4.0; IQR 3.0-6.0) (p = 0.042). The results in group A showed a reduction in the urgent visits due to acute overhydration (group A: 0.17 ± 0.45 versus group B: 0.66 ± 1.36) (p: 0.042) and in the number of disease-specific hospitalization (group A n = 2.0; 18.2% versus group B n = 7.0; 77.8%) (p = 0.022). We did not find any difference between the two groups in terms of hospitalization because of all-cause, peritonitis, overhydration, and dropout. The analysis of KDQOL-SF subscales was similar in the two groups; on the contrary, the answers of our pointed questions have showed a significant difference between the two groups (group A: 100 IQR 87.5-100.0 versus group B 87.5; IQR 75.0-100.0) (p: 0.018). Conclusion RM improved clinical outcomes in PD patients, reducing the emergency visits and the hospitalizations, related to nephrological problems, especially in patients with higher comorbidity score. The acceptance and satisfaction of care were better in patients monitored with RM than with standard APD.

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Section: Introductionmentioning

confidence: 99%

Remote monitoring in peritoneal dialysis: benefits on clinical outcomes and on quality of life

et al. 2020

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“…Several recent studies [41, 42] have further demonstrated that changes in serum albumin were significantly negatively correlated with mortality in PD patients. In addition, other studies [43–45] have shown a significant correlation between low serum albumin levels and the development of peritonitis.…”

Section: Other Novel Parametersmentioning

confidence: 98%

Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients

et al. 2022

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Patients with end-stage renal disease (ESRD) have significantly lower survival rates compared with the general population of the same age. Peritoneal dialysis (PD) is an effective treatment for patients with ESRD, but the clinical outcome of PD patients is still not promising. The survival of PD patients is associated with various clinical factors, and exploring some valid risk predictors may be beneficial for this population. In this review, by integrating the latest research, we summarized the association of some common and novel liver function parameters (ALT, AST, ALP, GGT, serum bilirubin, pre-albumin, albumin, albumin-globulin ratio [AGR], serum ferritin, and hyaluronic acid) with clinical outcomes in PD patients. It may contribute to a better understanding of potential risk factors and help to develop strategies to prevent the disease progression.

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“…The PDOPPS group has demonstrated associations between hypokalemia and markers of inflammation, protein energy wasting, and reduced muscle mass, 32 in support of these hypotheses. Similarly, hypoalbuminemia, especially a declining trajectory of serum albumin over time, 36,37 has been consistently associated with a higher risk of peritonitis. [38][39][40] Despite its predictive value, however, there is very low certainty evidence that nutritional interventions affect subsequent peritonitis risk.…”

Section: Patient-relatedmentioning

confidence: 99%

Peritoneal Dialysis–Related Infections

Cho

Chow

et al. 2023

CJASN

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Peritoneal dialysis represents an important treatment choice for patients with kidney failure. It allows them to dialyze outside the hospital setting, facilitating enhanced opportunities to participate in life-related activities, flexibility in schedules, time and cost savings from reduced travel to dialysis centers, and improved quality of life. Despite its numerous advantages, the peritoneal dialysis utilization has been static or diminishing in parts of the world. Peritoneal dialysis-related infections, such as peritonitis, exit-site infection or tunnel infection, is a major concern for patients, caregivers, and health professionals – which may result in hesitation to consider this as treatment or to cease therapy when these complications take place. In this review, the definition, epidemiology, risk factors, prevention, and treatment of peritoneal dialysis-related infection based on the contemporary evidence will be described.

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Changes in serum albumin concentrations during transition to dialysis and subsequent risk of peritonitis after peritoneal dialysis initiation: a retrospective cohort study

Cited by 9 publications

References 44 publications

Remote monitoring in peritoneal dialysis: benefits on clinical outcomes and on quality of life

Remote monitoring in peritoneal dialysis: benefits on clinical outcomes and on quality of life

Associations between liver function parameters and poor clinical outcomes in peritoneal dialysis patients

Peritoneal Dialysis–Related Infections

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