Changes in salivary cortisol levels as a prognostic predictor in children with anorexia nervosa

Shibuya, Ikuhiko; Nagamitsu, Shinichiro; Okamura, Hisayoshi; Komatsu, Hiroko; Ozono, Shuichi; Yamashita, Yushiro; Matsuishi, Toyojiro

doi:10.1016/j.ijpsycho.2011.08.008

Cited by 19 publications

(12 citation statements)

References 37 publications

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“…Finally, starvation alters multiple hormonal systems including the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic pituitary gonadotropic axis (HPG), both of which play known neuromodulatory roles and may influence learning and habit formation. Several groups have described chronically elevated tonic levels of cortisol in acutely ill patients with AN [52][53][54] which tend to normalize with weight restoration.…”

Section: Learning Habit Formation Stress and Fear Conditioning: Relmentioning

confidence: 99%

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Guarda¹,

Schreyer²,

Boersma³

et al. 2015

Physiology & Behavior

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Section: Learning Habit Formation Stress and Fear Conditioning: Relmentioning

confidence: 99%

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Guarda¹,

Schreyer²,

Boersma³

et al. 2015

Physiology & Behavior

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“…It would be interesting to study our sample 6 months after discharge from the clinic to see whether longterm weight restoration results in restored salivary cortisol and DHEA profiles. A recent study of salivary cortisol in adolescents with AN showed that the change in cortisol level before and after inpatient treatment correlated with increased body weight gain ratio just after treatment, but not with the ratio after 1 year (Shibuya et al 2011).…”

Section: Discussionmentioning

confidence: 95%

Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa

Oskis¹,

Loveday²,

Hucklebridge³

et al. 2012

Stress

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Although there is well-documented evidence for hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis function in anorexia nervosa (AN), there has been little research into secretory patterns of salivary cortisol and dehydroepiandrosterone (DHEA) in this condition. The cortisol awakening response (CAR), a prominent and discrete feature of the cortisol cycle, has not been extensively explored in adolescent AN. Saliva samples were collected at awakening, 30 min and 12 h post-awakening on two consecutive weekdays from eight female adolescents with clinically diagnosed AN and 41 healthy control (HC) age-matched females. Adolescent AN patients had greater salivary cortisol and DHEA concentrations than HC girls at all points. Increased hormone secretion was unrelated to body mass index. However, despite hypersecretion of both hormones, the circadian pattern including the CAR paralleled that of the HC group. Findings from this preliminary study confirm dysregulation of HPA axis function in adolescent AN as evidenced by hypersecretion of both cortisol and DHEA, which share the common secretagogue adrenocorticotropic hormone. However, the parallel diurnal profiles for AN and HC participants, including the CAR, may indicate hypersecretion per se rather than differential regulation of the diurnal pattern of these two adrenal steroids in AN.

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“…Young people at familial risk of depression but with no personal history of mood disorders have higher cortisol secretion compared with controls with no familial history of depression, indicating that elevated cortisol secretion may serve as a vulnerability marker of major depression [6]. Increased HPA-axis activity has been reported in children with anorexia nervosa, a condition in which cortisol concentration is positively associated with the severity of illness, and relative change in cortisol predicts disease prognosis [7]. …”

Section: Resultsmentioning

confidence: 99%

High correlation between salivary cortisol awakening response and the psychometric profiles of healthy children

Shibuya

Nagamitsu

Okamura

et al. 2014

BioPsychoSocial Med

Self Cite

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BackgroundCortisol awakening response (CAR) as an indicator of psychological stress and related physical and psychiatric diseases has attracted growing attention from researchers. Although CAR changes have been investigated extensively in children with behavioral and psychiatric disorders, the association between CAR and conventional psychometric scales for healthy children has not been reported. The aim of this study was to investigate the association between salivary CAR and subscales of Profiles of Mood States (POMS), a self-assessment questionnaire widely used to evaluate the temporal emotional states of healthy children.FindingsThis study included 18 healthy girls aged 13–16 years. Saliva was collected immediately on awakening, 30 min and 60 min after waking, and then at 2-hour intervals from 9 am to 5 pm. The current mood state, including depression, anxiety, fatigue, and other psychometric profiles were assessed using POMS. The magnitude of salivary CAR and the area under the concentration-time curve (AUC) for diurnal salivary cortisol were compared with the profiles. There were significant positive correlations between the magnitude of CAR and the POMS subscales for "Depression-Dejection", "Tension-Anxiety", "Fatigue", and "Confusion". No correlation was found between the AUC salivary cortisol level and the psychometric profiles.ConclusionsSalivary CAR was associated with various mood states of healthy female children but diurnal salivary cortisol AUC was not. Salivary CAR may be a biomarker of the physical and mental condition of healthy female children.

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Changes in salivary cortisol levels as a prognostic predictor in children with anorexia nervosa

Cited by 19 publications

References 37 publications

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Anorexia nervosa as a motivated behavior: Relevance of anxiety, stress, fear and learning

Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa

High correlation between salivary cortisol awakening response and the psychometric profiles of healthy children

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