Changes in Reverse Transcription Polymerase Chain Reaction–positive Severe Acute Respiratory Syndrome Coronavirus 2 Rates in Adults and Children According to the Epidemic Stages

Lévy, Corinne; Basmaci, Romain; Bensaïd, Philippe; bru, Cecile Bost; Coinde, Edeline; Dessioux, Emmanuelle; C, Fournial; Gashignard, Jean; Haas, H.; Hentgen, Véronique; Huet, Frédéric; Lalande, M.; Martinot, A.; Pons, Charlotte; Romain, Anne-Sophie; Ursulescu, Nicoleta; Sage, F. Vié Le; Raymond, Josette; Béchet, Stéphane; Toubiana, Julie; Cohen, Robert

doi:10.1097/inf.0000000000002861

Cited by 15 publications

(15 citation statements)

References 8 publications

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“…Weeks or months later, children also seemed to be less often infected than adults and to play a minor role in the pandemic dynamic. However, although the prevalence of SARS-CoV-2 infection in children is lower than in adults, the curve for children follows the adult prevalence, and contaminations could also occur from children to other children and adults (3). Given the broad spectrum of SARS-CoV-2 manifestations in children, which are often similar to other highly prevalent viral infections in childhood, detecting SARS-CoV-2-infected children efficiently and quickly is crucial (particularly before hospitalization) in school and daycare centers but also in the family (4,5).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of SARS-CoV-2 Antigen Detection Test in Children: A Real-Life Study

Jung

Lévy

Varon³

et al. 2021

Front. Pediatr.

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Naso-pharyngeal RT-PCR is the gold standard for the diagnosis of COVID-19, but there is a need for rapid and reliable tests. Some validation studies have used frozen aliquots mainly from adults. The aim of this real-life study was to test the performance of a SARS-CoV-2 rapid antigen test (SC2-RAT) in children. Symptomatic patients aged 0 to 17 years were recruited in the emergency department of the University Hospital of Creteil and in primary care pediatric practices from October 10, 2020 for 7 weeks. Each enrolled child had a SARS-CoV-2 RT-PCR test and a SC2-RAT from two distinct nasopharyngeal swabs. Among the 308 patients (mean [SD] age 4.9 [5.3] years), fever was the main symptom (73.4%), with no difference between COVID-19–negative and –positive groups. The prevalence of COVID-19 was 10.7% (95% CI 7.5–14.7). On the whole cohort, the sensitivity and specificity of the SC2-RAT compared to RT-PCR was 87.9% (95% CI 71.8–96.6) and 98.5% (95% CI 96.3–99.6). Considering samples with cycle threshold >25, the sensibility was lower: 63.6% (95% CI 30.8–89.1) and the specificity 99.6% (95% CI 98.0–100.0). The mean delay to obtain an SC2-RAT result was <15 min but was 3.2 h (SD 5.5) for an RT-PCR result. Contact with a COVID-19–positive person was more frequent for COVID-19–positive than –negative patients (n = 21, 61.6%, vs. n = 64, 24.6%; p < 0.01). In real life, SC2-RAT seems reliable for symptomatic children, allowing to detect contagious children.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of SARS-CoV-2 Antigen Detection Test in Children: A Real-Life Study

Jung

Lévy

Varon³

et al. 2021

Front. Pediatr.

Self Cite

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“…Since December 2019, this virus was responsible for a pandemic that reached more than 100 million people and caused 2.3 million deaths worldwide as of February 2021 1 . Children are less often affected than adults and have exceptionally severe illness (1)(2)(3)(4). At the beginning of the pandemic, the disease was assumed to be transmitted mainly via children, as observed during influenza epidemics; school closures proved effective in limiting the spread of the disease (5).…”

Section: Introductionmentioning

confidence: 99%

“…At the beginning of the pandemic, the disease was assumed to be transmitted mainly via children, as observed during influenza epidemics; school closures proved effective in limiting the spread of the disease (5). By analogy with the flu, to protect children and fight against the spread of COVID-19, as part of the lockdown, many countries made the drastic decision to close schools and universities 2 . Thus, at the end of March 2020, 166 countries had implemented this measure, depriving 1.5 billion schoolchildren and students of education 2 .…”

Section: Introductionmentioning

confidence: 99%

“…By analogy with the flu, to protect children and fight against the spread of COVID-19, as part of the lockdown, many countries made the drastic decision to close schools and universities 2 . Thus, at the end of March 2020, 166 countries had implemented this measure, depriving 1.5 billion schoolchildren and students of education 2 .…”

Section: Introductionmentioning

confidence: 99%

“…The visor is useful 1 Available online at: https://www.statista.com/statistics/1093256/novelcoronavirus-2019ncov-deaths-worldwide-by-country/ (accessed February 11, 2021). 2 Available online at: https://en.unesco.org/covid19/educationresponse (accessed February 11, 2021). 3 Available online at: https://afpa.org/content/uploads/2021/01/Position-de-la-SFP-AFPA-25-janvier-2021-002.pdf (accessed February 11, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Face Masks in Young Children During the COVID-19 Pandemic: Parents' and Pediatricians' Point of View

et al. 2021

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Background: In countries with high SARS-CoV-2 circulation, the pandemic has presented many challenges on different fronts, affecting lives and livelihoods; efforts to keep schools open are among the most important. In France, to keep schools open, wearing a face mask has been mandatory for children from age 6 years since November 2020.Objective: To evaluate the acceptability and tolerance of this measure by children as well as both parents and pediatricians.Setting: Parents registered on the website of the French Association of Ambulatory Pediatrics and pediatricians members of this association.Participants: All parents and pediatricians who agreed to take part in the survey.Results: Among the 2,954 questionnaires for the parents' survey, the reasons for wearing a mask were understood by 54.6% of parents, most of whom (84.6%) explained the reasons to their children. The parents applied this measure because it was mandatory (93.4%) even if they disagreed (63.3%). When interviewed by parents, children said they were usually embarrassed (80.9%) by the mask. The main symptoms or changes of behavior attributed to the mask according to parents were headache (49.0%), speaking difficulties (45%), change in mood (45.2%) and breathing discomfort (28.1%). Among the 663 pediatricians who responded, many agreed with mandatory mask-wearing at age 6 years (67.7%). Overall, 15% of pediatricians systematically asked about the mask tolerance during the consultation. During the medical consultation, when the parents complained about the mask (64.3%), the main drawbacks were related to fog on glasses (reported by 68.2% of pediatricians), breathing discomfort (53.1% of pediatricians), cutaneous disorders (42.4% of pediatricians) and headaches (38.2% of pediatricians).Conclusion: Despite the many inconveniences reported, children agree to wear the mask better than their parents think. Pediatricians should sufficiently take the opportunity during the consultation to further explain the reasons for wearing the mask because their pedagogical role is crucial.

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Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France

et al. 2021

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Changes in Reverse Transcription Polymerase Chain Reaction–positive Severe Acute Respiratory Syndrome Coronavirus 2 Rates in Adults and Children According to the Epidemic Stages

Cited by 15 publications

References 8 publications

Diagnostic Accuracy of SARS-CoV-2 Antigen Detection Test in Children: A Real-Life Study

Diagnostic Accuracy of SARS-CoV-2 Antigen Detection Test in Children: A Real-Life Study

Face Masks in Young Children During the COVID-19 Pandemic: Parents' and Pediatricians' Point of View

Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France

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