Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study

Berrones, David; Salcedo-Villanueva, Guillermo; Morales-Cantón, Virgilio; Vélez-Montoya, Raúl

doi:10.1155/2017/7174540

Cited by 12 publications

(7 citation statements)

References 39 publications

(31 reference statements)

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“… 19 Other reports, however, show that sildenafil does not significantly increase choroidal blood flow. Berrones et al 20 used optical coherence tomography-angiography (OCT-A) to monitor ocular vascular changes and reported a significant increase in central choroidal thickness (CCT) and no change in choroidal blood flow in healthy patients one-hour following administration of 50 mg oral sildenafil compared to controls. They also reported a significant increase in outer retina blood flow and no change in retinal capillary density after sildenafil administration.…”

Section: Discussionmentioning

confidence: 99%

Unilateral acute anterior uveitis with macular edema following the use of sildenafil citrate in a patient with HLA-B27 positivity

Regenold

Ghoraba

Akhavanrezayat

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose To present a case of acute anterior uveitis with macular edema associated with sildenafil citrate use in an HLA-B27 positive patient. Observations A 54-year-old Caucasian male presented at an ophthalmology tertiary center with complaint of pinkish discoloration, irritation, and photophobia in the left eye (OS). He noted that these symptoms appeared one day after using sildenafil for the first time to treat his erectile dysfunction. The patient had no significant ocular history besides refractive surgery in both eyes (OU) and his medical history was insignificant. Best-corrected visual acuity (BCVA) was 20/20 in the right eye (OD) and 20/25 in OS. Slit-lamp-examination (SLE) demonstrated trace cells and 1+ flare in the anterior chamber (AC) in OS and was nonrevealing in AC in OD. Spectral domain optical coherence tomography (SD-OCT) showed parafoveal subretinal hyperreflective deposits in OU. The patient was diagnosed with acute anterior uveitis (AAU) in the left eye and was placed on topical prednisolone acetate. At 2-week follow-up, the patient reported that his eye symptoms had improved since starting topical steroids but worsened again two days after he had used sildenafil for a second time. In OS, best-corrected visual acuity (BCVA) worsened to 20/40, and SLE revealed 1+ cells and 1+ flare in AC. SD-OCT revealed cystoid macular edema only in OS. Fluorescein angiography showed mild staining around the optic disc and significant macular leakage in OS and minimal macular leakage in OD. Uveitis evaluations revealed that the patient was human leukocyte antigen-27 (HLA-B27) positive. The patient was asked to remain off sildenafil and continue topical prednisolone acetate. At 3-month follow-up, BCVA improved to 20/20 in OS with no evidence of active inflammation. Conclusions and importance Sildenafil citrate use might be associated with new onset of intraocular inflammation in predisposed patients. Further studies are necessary to establish this relationship.

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Section: Discussionmentioning

confidence: 99%

Unilateral acute anterior uveitis with macular edema following the use of sildenafil citrate in a patient with HLA-B27 positivity

Regenold

Ghoraba

Akhavanrezayat

et al. 2021

American Journal of Ophthalmology Case Reports

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“…[10] Altered vascular perfusion is a known feature of CSCR associated with phosphodiesterase inhibitors (tadalafil, sildenafil); and a possible factor in mefloquine-associated CSCR. [211]…”

Section: Discussionmentioning

confidence: 99%

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways

Jain

2019

Indian J Ophthalmol

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A 30-year-old insomniac, an off-label user of quetiapine, presented with blurring of central vision, eventually diagnosed as central serous chorioretinopathy. A potential association was suspected based on the drug's actions on the autonomic nervous system. He showed improvement on drug withdrawal; then he unwittingly resumed quetiapine and had a recurrence. Possible underlying mechanisms that include alteration in choroidal perfusion through serotonin and dopamine receptors are discussed. Although retinal vein occlusions and pigment epithelial detachment have been described with quetiapine, to the author's knowledge, this is the first case report of quetiapine-associated central serous chorioretinopathy.

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“…In the normal eye, the choroidal circulation nurtures the outer retina, whereas the central retinal artery and its end branches feed the inner retina and mid-retina. Due to the connection between these two systems (3,4), the bipartite vascularization ensures minimum supply for retinal hemodynamics (5). Animal models have shown that the choroid supply of oxygen to the inner retina may be sufficient to maintain ganglion cell viability even when the retinal vessels have been completely Experimental data has suggested that preconditioning events (prior episodes of ischaemia) may induce "ischaemic tolerance" in the retina and result in reduced anatomical and functional damage (6,7).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous resolution of myopic retinoschisis

Chu

Pong

2019

AME Case Rep

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Spontaneous resolution of myopic retinoschisis is an unusual event due to the fact that most eyes of patients with this condition have already undergone certain morphological changes and vision will progressively worsen over time. We present a case of spontaneous anatomic and visual improvement in a myopic eye with a macular retinoschisis. The patient was monocular oculus dextrus (OD) with a history of left eye enucleation for recurrent retinal detachment and glaucoma for 30 years prior. Recent optical coherence tomography (OCT) depicted features characteristic of myopic retinoschisis. At the same time, the patient sough chiropractic treatment for neck pain and numbness in upper limbs. The patient had received 12 sessions of cervical adjustment which helped attain symptomatic relief of her neck and upper limb complaints at which time the patient also reported substantial recovery in her vision. Restoration of the normal retinal morphological appearance was illustrated upon re-evaluation of OCT. Spontaneous resolution of myopic retinoschisis may be a multifactorial cause. Further studies elucidating the exact mechanism resulting in visual improvement after chiropractic adjustment are needed before any claims regarding its efficacy for the treatment of myopic retinoschisis can be made.

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Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study

Cited by 12 publications

References 39 publications

Unilateral acute anterior uveitis with macular edema following the use of sildenafil citrate in a patient with HLA-B27 positivity

Unilateral acute anterior uveitis with macular edema following the use of sildenafil citrate in a patient with HLA-B27 positivity

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways

Spontaneous resolution of myopic retinoschisis

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