Changes in Resting-State Functional Connectivity Related to Freezing of Gait in Parkinson's Disease

Potvin‐Desrochers, Alexandra; Mitchell, Trina; Gisiger, Thomas; Paquette, Caroline

doi:10.1016/j.neuroscience.2019.08.042

Cited by 25 publications

(20 citation statements)

References 28 publications

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“…Interestingly, a recent rs‐fMRI study by Potvin‐Desrochers et al demonstrated increased thalamic/GPi connectivity with visual areas as well as between the left putamen and cerebellum in patients with FoG compared to those without. In contrast to prior studies, this increased connectivity in cortical and subcortical regions involved in sensory and visuospatial processing may serve as a compensatory pathway for sensorimotor deficits in FoG (59). A limitation of functional imaging studies is that they do not capture the brain network activities during gait freezing episodes.…”

Section: Pathophysiology Of Freezing Of Gaitcontrasting

confidence: 83%

Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation

Rahimpour

Gaztanaga

Yadav

et al. 2021

Neuromodulation: Technology at the Neural Interface

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Introduction: Freezing of gait (FoG) is one of the most disabling yet poorly understood symptoms of Parkinson's disease (PD). FoG is an episodic gait pattern characterized by the inability to step that occurs on initiation or turning while walking, particularly with perception of tight surroundings. This phenomenon impairs balance, increases falls, and reduces the quality of life.Materials and Methods: Clinical-anatomical correlations, electrophysiology, and functional imaging have generated several mechanistic hypotheses, ranging from the most distal (abnormal central pattern generators of the spinal cord) to the most proximal (frontal executive dysfunction). Here, we review the neuroanatomy and pathophysiology of gait initiation in the context of FoG, and we discuss targets of central nervous system neuromodulation and their outcomes so far. The PubMed database was searched using these key words: neuromodulation, freezing of gait, Parkinson's disease, and gait disorders. Conclusion:Despite these investigations, the pathogenesis of this process remains poorly understood. The evidence presented in this review suggests FoG to be a heterogenous phenomenon without a single unifying pathologic target. Future studies rigorously assessing targets as well as multimodal approaches will be essential to define the next generation of therapeutic treatments.

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Section: Pathophysiology Of Freezing Of Gaitcontrasting

confidence: 83%

Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation

Rahimpour

Gaztanaga

Yadav

et al. 2021

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

show abstract

“…More recently, a seed-based fMRI FC study demonstrated that PD is associated with increased static FC between the motor subdivisions of the thalamus (VL/ventral anterior nuclei) and the supplementary motor area and between the prefrontal thalamic subdivisions (mediodorsal and anterior nuclei) and the basal ganglia nuclei or anterior and dorsolateral prefrontal cortices (36). A seed-to-voxel static FC study performed with the seeds in the bilateral basal ganglia nuclei, thalamus, and pedunculopontine nucleus revealed that FC of bilateral thalamus and globus pallidus external with visual cortex was significantly increased in PD-FOG compared to PD-NFOG (15). The discrepancy between our study results and previous reports may be attributed to differences in the placement of ROIs and subjects recruited.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to taskbased fMRI analyses, resting-state fMRI functional connectivity (FC), which requires no experimental task, can be used to study multiple neural systems simultaneously. Aberrant static FC is frequently reported in PD-FOG (14)(15)(16)(17). Despite extensive evidence for abnormal regional and network activity in PD patients, studies focusing on the alterations of thalamocortical connectivity are scarce, especially in those with FOG.…”

Section: Introductionmentioning

confidence: 99%

More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait

et al. 2021

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Background: The thalamus is not only a key relay node of the thalamocortical circuit but also a hub in the regulation of gait. Previous studies of resting-state functional magnetic resonance imaging (fMRI) have shown static functional connectivity (FC) between the thalamus and the cortex are disrupted in Parkinson's disease (PD) patients with freezing of gait (FOG). However, temporal dynamic FC between the thalamus and the cortex has not yet been characterized in these patients.Methods: Fifty PD patients, including 25 PD patients with FOG (PD-FOG) and 25 PD patients without FOG (PD-NFOG), and 25 healthy controls (HC) underwent resting-state fMRI. Seed-voxel-wise static and dynamic FC were calculated between each thalamic nuclei and other voxels across the brain using the 14 thalamic nuclei in both hemispheres as regions of interest. Associations between altered thalamic FC based on significant inter-group differences and severity of FOG symptoms were also examined in PD-FOG.Results: Both PD-FOG and PD-NFOG showed lower static FC between the right lateral posterior thalamic nuclei and right inferior parietal lobule (IPL) compared with HC. Altered FC dynamics between the thalamic nuclei and several cortical areas were identified in PD-FOG, as shown by temporal dynamic FC analyses. Specifically, relative to PD-NFOG or HC, PD-FOG showed greater fluctuations in FC between the left intralaminar (IL) nuclei and right IPL and between the left medial geniculate and left postcentral gyrus. Furthermore, the dynamics of FC between the left pulvinar anterior nuclei and left inferior frontal gyrus were upregulated in both PD-FOG and PD-NFOG. The dynamics of FC between the right ventral lateral nuclei and left paracentral lobule were elevated in PD-NFOG but were maintained in PD-FOG and HC. The quantitative variability of FC between the left IL nuclei and right IPL was positively correlated with the clinical scales scores in PD-FOG.Conclusions: Dynamic FC between the thalamic nuclei and relevant associative cortical areas involved in sensorimotor integration or cognitive function was disrupted in PD-FOG, which was reflected by greater temporal fluctuations. Abnormal dynamic FC between the left IL nuclei of the thalamus and right IPL was related to the severity of FOG.

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“…The current findings of the higher neural level (cerebellum, basal ganglia, locomotion regions, and cortex) activities of FOG mainly arise from the resting-state functional magnetic resonance imaging (fMRI) studies (Nutt, 2013 ; Gilat et al, 2015 ; Wang et al, 2016 ; Bharti et al, 2019 ; Potvin-Desrochers et al, 2019 ). However, FOG is a dynamic disorder that tended to be developed during motion.…”

Section: Introductionmentioning

confidence: 99%

Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait

Chen

Liu

et al. 2021

Front. Aging Neurosci.

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Background: Freezing of gait (FOG) in Parkinson's disease (PD) is a devastating clinical phenomenon that has a detrimental impact on patients. It tends to be triggered more often during turning (complex) than during forwarding straight (simple) walking. The neural mechanism underlying this phenomenon remains unclear and requires further elucidation.Objective: To investigate the differences in cerebral functional magnetic resonance imaging responses between PD patients with and without FOG during explicitly video-guided motor imagery (MI) of various complex (normal, freezing) and simple (normal, freezing) walking conditions.Methods: We recruited 34 PD patients, namely, 20 with FOG and 14 without FOG, and 15 normal controls. Participants underwent video-guided MI of turning and straight walking, with and without freezing, while their brain blood oxygen level-dependent (BOLD) activities were measured. Gait analysis was performed.Results: While comparing FOG turning with FOG straight walking, freezers showed higher activation of the superior occipital gyrus, left precentral gyrus, and right postcentral gyrus compared with non-freezers. Normal controls also manifest similar findings compared with non-freezers, except no difference was noted in occipital gyrus activity between the two groups. Freezers also displayed a higher effect size in the locomotor regions than non-freezers during imagery of normal turning.Conclusions: Our findings suggest that freezers require a higher drive of cortical and locomotion regions to overcome the overinhibition of the pathways in freezers than in non-freezers. Compared with simple walking, increased dorsal visual pathway and deep locomotion region activities might play pivotal roles in tackling FOG in freezers during complex walking.

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Changes in Resting-State Functional Connectivity Related to Freezing of Gait in Parkinson's Disease

Cited by 25 publications

References 28 publications

Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation

Freezing of Gait in Parkinson’s Disease: Invasive and Noninvasive Neuromodulation

More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait

Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait

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