Changes in resting connectivity with age: a simultaneous electroencephalogram and functional magnetic resonance imaging investigation

Balsters, Joshua H.; O’Connell, Redmond G; Galli, Alessandra; Nolan, Hugh; Greco, Eleanora; Kilcullen, Sophia M.; Bokde, Arun L.W.; Lai, Robert; Upton, Neil; Robertson, Ian H.

doi:10.1016/j.neurobiolaging.2013.03.004

Cited by 43 publications

(37 citation statements)

References 84 publications

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“…In line with the present findings, a combined EEG/fMRI study also found opposing age-activity relations for cortical DMN and the HC (28), with an age decrease in cortical DMN beta power along with an age increase in HC beta power. The basis for differential influences of advancing age on key components of the DMN remains to be determined.…”

Section: Hippocampus Proper As Segmented By Freesurfersupporting

confidence: 91%

“…In addition, aging may affect cardiovascular dynamics, and although ICA can help to disentangle such confounding variables from RSNs, it cannot be ruled out that the observed differences in RSNs at least in part reflected nonneural factors. Critically, however, the related observation of an age-related EEG increase in HC RSN activity (28) suggests that our finding of an age-related increase in HC-fMRI connectivity has a neural origin. We used ICA components to define RS networks (defined as spatially independent but temporally correlated sets of regions), but note that there are various ways to characterize and estimate networks.…”

Section: Hippocampus Proper As Segmented By Freesurfercontrasting

confidence: 51%

“…Critically, higher subcortical RSN connectivity was found to correlate negatively with EM performance in an aging sample (27). Moreover, a recent combined fMRI/EEG study observed age increases in HC EEG beta power during rest (28).…”

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confidence: 88%

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Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging

Salami

Pudas

Nyberg

2014

Proc. Natl. Acad. Sci. U.S.A.

168

170

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The brain is not idle during rest. Functional MRI (fMRI) studies have identified several resting-state networks, including the default mode network (DMN), which contains a set of cortical regions that interact with a hippocampus (HC) subsystem. Age-related alterations in the functional architecture of the DMN and HC may influence memory functions and possibly constitute a sensitive biomarker of forthcoming memory deficits. However, the exact form of DMN-HC alterations in aging and concomitant memory deficits is largely unknown. Here, using both task and resting data from 339 participants (25-80 y old), we have demonstrated agerelated decrements in resting-state functional connectivity across most parts of the DMN, except for the HC network for which agerelated elevation of connectivity between left and right HC was found along with attenuated HC-cortical connectivity. Elevated HC connectivity at rest, which was partly accounted for by age-related decline in white matter integrity of the fornix, was associated with lower cross-sectional episodic memory performance and declining longitudinal memory performance over 20 y. Additionally, elevated HC connectivity at rest was associated with reduced HC neural recruitment and HC-cortical connectivity during active memory encoding, which suggests that strong HC connectivity restricts the degree to which the HC interacts with other brain regions during active memory processing revealed by task fMRI. Collectively, our findings suggest a model in which age-related disruption in cortico-hippocampal functional connectivity leads to a more functionally isolated HC at rest, which translates into aberrant hippocampal decoupling and deficits during mnemonic processing.hippocampus | DMN | resting state | episodic memory | aging T he brain is not idle at rest (1). Rather, intrinsic neuronal signaling, which manifests as spontaneous fluctuations in the blood oxygen level-dependent (BOLD) functional MRI (fMRI) signal, is ubiquitous in the human brain and consumes a substantial portion of the brain's energy (2). Coherent spontaneous activity has been revealed in a hierarchy of networks that span large-scale functional circuits in the brain (3-6). These resting-state networks (RSNs) show moderate-to-high test-retest reliability (7) and replicability (8), and some have been found in the monkey (9) and infant (10) brain. In the adult human brain, RSNs include sensory motor, visual, attention, and mnemonic networks, as well as the default mode network (DMN). There is evidence that the DMN entails interacting subsystems and hubs that are implicated in episodic memory (11-13). One major hub encompasses the posterior cingulate cortex and the retrosplenial cortex. Other hubs include the lateral parietal cortex and the medial prefrontal cortex. In addition, a hippocampus (HC) subsystem is distinct from, yet interrelated with, the major cortical DMN hubs (12,14).The functional architecture of the DMN and other RSNs is affected by different conditions, such as Alzheimer's disease (AD), Parkinson...

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Section: Hippocampus Proper As Segmented By Freesurfersupporting

confidence: 91%

Section: Hippocampus Proper As Segmented By Freesurfercontrasting

confidence: 51%

See 1 more Smart Citation

Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging

Salami

Pudas

Nyberg

2014

Proc. Natl. Acad. Sci. U.S.A.

168

170

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“…In a similar vein, these results provide evidence against the notion that the observed reduction in BOLD activation in older adults during the resting state is due to age-related differences in cerebral vasculature alone (Bangen et al, 2009;D'Esposito, Deouell & Gazzaley, 2003;Kannurpatti et al, 2010 (Balsters et al, 2013).…”

Section: Discussionsupporting

confidence: 49%

Aging and large-scale functional networks: White matter integrity, gray matter volume, and functional connectivity in the resting state

et al. 2015

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Healthy ageing is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities. The aim of this study was to investigate the effect of global age-related differences in the cortical white and gray matter on neural activity in three key large-scale networks. We used functionalstructural covariance network analysis to assess resting state activity in the default mode network (DMN), the fronto-parietal network (FPN), and the salience network show that, in the direct comparison of resting state activity, young but not older adults reliably engage the SN and FPN in addition to the DMN, suggesting that older adults recruit these networks less consistently. Second, our results demonstrate that agerelated decline in white matter integrity and gray matter volume is associated with activity in prefrontal nodes of the SN and FPN, possibly reflecting compensatory mechanisms. We suggest that age-related differences in gray and white matter properties differentially affect the ability of the brain to engage and coordinate largescale functional networks that are central to efficient cognitive functioning.

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“…(2013). In order to account for differences in breathing and heart rate across age‐groups, and individuals, we collected both respiratory and cardiac pulse data for all participants and regressed these from participant's functional data.…”

Section: Discussionmentioning

confidence: 99%

Thalamic functional connectivity and its association with behavioral performance in older age

et al. 2018

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IntroductionDespite the thalamus’ dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo‐cortical and thalamo‐hippocampal functional connectivity (FC) and the association between thalamic FC and visual–spatial memory and reaction time (RT) performance in older adults.MethodsResting‐state functional magnetic resonance images were obtained from younger (n = 20) and older (n = 20) adults. A seed‐based approach was used to assess the FC between the thalamus and (1) sensory resting‐state networks; (2) the hippocampus. Participants also completed visual–spatial memory and RT tasks, from the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsOlder adults exhibited a loss of specificity in the FC between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo‐motor FC in older adults was associated with faster RTs. Furthermore, older adults exhibited greater thalamo‐hippocampal FC compared to younger adults, which was greatest for those with the poorest visual–spatial memory performance.ConclusionAlthough older adults exhibited poorer visual–spatial memory and slower reaction times compared to younger adults, “good” and “poorer” older performers exhibited different patterns of thalamo‐cortical and thalamo‐hippocampal FC. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. Furthermore, these results highlight the importance of including the thalamus in studies of aging to fully understand how brain changes with age may be associated with behavior.

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Changes in resting connectivity with age: a simultaneous electroencephalogram and functional magnetic resonance imaging investigation

Cited by 43 publications

References 84 publications

Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging

Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging

Aging and large-scale functional networks: White matter integrity, gray matter volume, and functional connectivity in the resting state

Thalamic functional connectivity and its association with behavioral performance in older age

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