Changes in Regional Blood Flow Induced by Unilateral Subthalamic Nucleus Stimulation in Patients With Parkinson's Disease

Tanei, Takafumi; Kajita, Yasukazu; Nishizaki, Takashi; Kaneoke, Yoshiki; Takebayashi, Shigenori; Nakatsubo, Daisuke; Wakabayashi, Toshihiko

doi:10.2176/nmc.49.507

Cited by 11 publications

(5 citation statements)

References 20 publications

(5 reference statements)

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“…This approach is supported by previous evidence of bilateral rCBF effects of unilateral stimulation [Tanei et al 2009; Arai et al 2008], and we compared the ipsilateral and contralateral rCBF changes to confirm that bilateral averaging did not mask effects of unilateral stimulation.…”

Section: Methodssupporting

confidence: 81%

“…Indeed the effects on gait in this study were more modest than those reported in response to clinically optimized DBS [Bastian et al 2003]. The influence of unilateral STN DBS on rCBF is not as well established, but accumulating evidence indicates that unilateral DBS produces bilateral rCBF responses [Tanei et al 2009; Arai et al 2008]. Bilateral connections of basal ganglia nuclei shown by anatomic studies [Marani et al 2008; Parent and Hazrati1995] likely account for the observed contralateral effects.…”

Section: Discussionmentioning

confidence: 70%

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Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease

Hill

Campbell

McNeely

et al. 2013

Experimental Neurology

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Objectives The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on gait and balance vary and the underlying mechanisms remain unclear. DBS location may alter motor benefit due to anatomical heterogeneity in STN. The purposes of this study were to (1) compare effects of DBS of dorsal (D-STN) versus ventral (V-STN) regions on gait, balance and regional cerebral blood flow (rCBF) and (2) examine relationships between changes in rCBF and changes in gait and balance induced by D-STN or V-STN DBS. Methods We used a validated atlas registration to locate and stimulate through electrode contacts in D-STN and V-STN regions of 37 people with Parkinson disease. In a within-subjects, double-blind and counterbalanced design controlled for DBS settings, we measured PET rCBF responses in a priori regions of interest and quantified gait and balance during DBS Off, unilateral D-STN DBS and unilateral V-STN DBS. Results DBS of either site increased stride length without producing significant group-level changes in gait velocity, cadence or balance. Both sites increased rCBF in subcortical regions and produced variable changes in cortical and cerebellar regions. DBS-induced changes in gait velocity related to premotor cortex rCBF changes during V-STN DBS (r = −0.40, p = 0.03) and to rCBF changes in the cerebellum anterior lobe during D-STN DBS (r = −0.43, p = 0.02). Conclusions DBS-induced changes in gait corresponded to rCBF responses in selected cortical and cerebellar regions. These relationships differed during D-STN versus V-STN DBS, suggesting DBS acts through distinct neuronal pathways dependent on DBS location.

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Section: Methodssupporting

confidence: 81%

Section: Discussionmentioning

confidence: 70%

Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease

Hill

Campbell

McNeely

et al. 2013

Experimental Neurology

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“…DC was increased in the left SFG of EOPD patients compared to YCs. The frontal gyrus is not only engaged in the control of motion (Tanei et al, 2009) but is also related to attention to the movement (Jueptner et al, 1997). It was proposed that overactivation of the SFG is a compensatory mechanism in EOPD (Long et al, 2012), which may also be characterized by altered regional volume and cerebral blood flow in this area (Yang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Distinct Changes in Global Brain Synchronization in Early-Onset vs. Late-Onset Parkinson Disease

Wang

Liao

et al. 2020

Front. Aging Neurosci.

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Early- and late-onset Parkinson’s disease (EOPD and LOPD, respectively) have different risk factors, clinical features, and disease course; however, the functional outcome of these differences have not been well characterized. This study investigated differences in global brain synchronization changes and their clinical significance in EOPD and LOPD patients. Patients with idiopathic PD including 25 EOPD and 24 LOPD patients, and age- and sex-matched healthy control (HC) subjects including 27 younger and 26 older controls (YCs and OCs, respectively) were enrolled. Voxel-based degree centrality (DC) was calculated as a measure of global synchronization and compared between PD patients and HC groups matched in terms of disease onset and severity. DC was decreased in bilateral Rolandic operculum and left insula and increased in the left superior frontal gyrus (SFG) and precuneus of EOPD patients compared to YCs. DC was decreased in the right putamen, mid-cingulate cortex, bilateral Rolandic operculum, and left insula and increased in the right cerebellum-crus1 of LOPD patients compared to OCs. Correlation analyses showed that DC in the right cerebellum-crus1 was inversely associated with the Hamilton Depression Scale (HDS) score in LOPD patients. Thus, EOPD and LOPD patients show distinct alterations in global synchronization relative to HCs. Furthermore, our results suggest that the left SFG and right cerebellum-crus1 play important roles in the compensation for corticostriatal–thalamocortical loop injury in EOPD and LOPD patients, whereas the cerebellum is a key hub in the neural mechanisms underlying LOPD with depression. These findings provide new insight into the clinical heterogeneity of the two PD subtypes.

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“…Second, the different patterns of spontaneous brain activity might reflect a difference in regional vulnerability across the PD subgroups. The frontal gyrus is involved in both control of motor processing (Tanei et al, 2009 ) and attention to action (Jueptner et al, 1997 ; Rowe et al, 2002 ). The associative circuit in the striatal-thalamo-cortical loop projects from associative cortical areas, such as the prefrontal cortex, to the caudate nucleus, and the putamen (Baglio et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease

Sheng

Fang

Zhu

et al. 2016

Front. Aging Neurosci.

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HIGHLIGHTS Eighteen EOPD, 21 LOPD and 37 age-matched normal control subjects participated in the resting state fMRI scans.Age at onset of PD modulates the distribution of cerebral regional homogeneity during resting state.Disproportionate putamen alterations are more prominent in PD patients with a younger age of onset.Objective: Early-onset Parkinson's disease (EOPD) is distinct from late-onset PD (LOPD) as it relates to the clinical profile and response to medication. The objective of current paper is to investigate whether characteristics of spontaneous brain activity in the resting state are associated with the age of disease onset.Methods: We assessed the correlation between neural activity and age-at-onset in a sample of 39 PD patients (18 EOPD and 21 LOPD) and 37 age-matched normal control subjects. Regional homogeneity (ReHo) approaches were employed using ANOVA with two factors: PD and age.Results: In the comparisons between LOPD and EOPD, EOPD revealed lower ReHo values in the right putamen and higher ReHo values in the left superior frontal gyrus. Compared with age-matched control subjects, EOPD exhibited lower ReHo values in the right putamen and higher ReHo values in the left inferior temporal gyrus; However, LOPD showed lower ReHo values in the right putamen and left insula. The ReHo values were negatively correlated with the UPDRS total scores in the right putamen in LOPD, but a correlation between the ReHo value and UPDRS score was not detected in EOPD.Conclusions: Our findings support the notion that age at onset is associated with the distribution of cerebral regional homogeneity in the resting state and suggest that disproportionate putamen alterations are more prominent in patients with a younger age of onset.

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Changes in Regional Blood Flow Induced by Unilateral Subthalamic Nucleus Stimulation in Patients With Parkinson's Disease

Cited by 11 publications

References 20 publications

Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease

Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease

Distinct Changes in Global Brain Synchronization in Early-Onset vs. Late-Onset Parkinson Disease

Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease

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