Changes in Refraction Caused by Induction of Acute Hyperglycemia in Healthy Volunteers

Furushima, Masatoshi; Imaizumi, Masamoto; Nakatsuka, Kazuo

doi:10.1016/s0021-5155(99)00098-2

Cited by 29 publications

(25 citation statements)

References 11 publications

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“…In the glucose loading study on healthy human volunteers, the myopic change was explained by the thickening of the lens, which led to a decrease in the tension of the zonule fibers of Zinn; moreover, in the normalization course of plasma glucose, a hyperopic reversal phenomenon was revealed [11]. Saito et al [12] also reported transient hyperopia in diabetic patients after glycemic control.…”

Section: Discussionmentioning

confidence: 99%

Transient Hyperopia after Intensive Treatment of Hyperglycemia in Newly Diagnosed Diabetes

Lin

Lin²,

Chang

et al. 2008

Ophthalmologica

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Purpose: Our aim was to observe the transient hyperopia during the intense glucose reduction in patients with newly diagnosed diabetes and severe hyperglycemia. Study Design: Consecutive cases were observed. Results: Totally 4 men and 1 woman with a mean age of 48 years were enrolled. In the 4 patients who received insulin, the hyperopia developed at 4.2 days after the initiation of treatment on average and reached a peak at 11.7 days; they recovered at 64.0 days. The other subject who received oral hypoglycemia agents revealed a peak change at 17 days and recovered at 70 days. A broader hyperopic change of 6.25 dpt was found in the patient with high myopia (–16 dpt). No significant difference was observed in the corneal curvature, axial length, lens thickness or depth of the anterior chamber during the course. The stable value of the accommodation amplitude and lens thickness may indicate that the cause of refraction change was due to the alteration in the reflection index of the lens. Conclusion: Intensive glucose reduction may cause transient hyperopia changes in newly diabetic patients and results in blurred vision.

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Section: Discussionmentioning

confidence: 99%

Transient Hyperopia after Intensive Treatment of Hyperglycemia in Newly Diagnosed Diabetes

Lin

Lin²,

Chang

et al. 2008

Ophthalmologica

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“…An OGTT in combination with a somatostatin injection was used to induce hyperglycemia. In an earlier study, this was shown to induce large changes in the refractive error and lens thickness [11]. Somatostatin inhibits insulin secretion [7], and to our knowledge there are no reports of refractive errors or changes in the lens due to this agent.…”

Section: Discussionmentioning

confidence: 99%

“…A myopic shift of maximal -0.75 D was measured with autorefractometry. Secondly, Furushima et al [11] induced hyperglycemia in seven healthy, young subjects through somatostatin injections and an oral glucose load. By means of autorefractometry and ultrasound biometry a large change in ocular refraction (-2.0 diopters (D)) and thickness of the lens (1.0 mm) was measured within 150 minutes after administration of the glucose load (maximal hyperglycemia: 13.9 mmol/l).…”

mentioning

confidence: 99%

“…In the study of Furushima et al [11], only the thickness of the lens was measured, and there is no information about the change in the shape and the refractive index of the lens due to acute hyperglycemia. Therefore, the aim of our study was to induce hyperglycemia in healthy subjects under controlled circumstances, and accurately measure ocular geometry and refraction by means of corrected Scheimpflug imaging and Hartmann-Shack aberrometry, in order to investigate the mechanism underlying refractive changes during hyperglycemia.…”

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confidence: 99%

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Refractive properties of the healthy human eye during acute hyperglycemia

Wiemer

Eekhoff

Şimşek

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Purpose To measure the refractive properties of the healthy human eye during acute hyperglycemia by means of Scheimpflug imaging and Hartmann-Shack aberrometry. Methods Acute hyperglycemia was induced in five healthy subjects (two males, three females, mean age ±SD 24.8 years ± 4.6) by means of an oral glucose tolerance test (OGTT) after subcutaneous somatostatin injection. Before and every 30 minutes after the OGTT, measurements with Scheimpflug imaging and Hartmann-Shack aberrometry were performed. The main outcome measures were the thickness and shape of the lens, and the ocular refractive error and higher order aberrations. The equivalent refractive index of the lens was calculated from these parameters. Measurements at baseline and during hyperglycemia were analyzed by means of Wilcoxon signed rank sum tests.Results During hyperglycemia (mean blood glucose level at baseline: 4.0 mmol/l; mean maximal blood glucose level: 18.4 mmol/l) no changes could be found in the refractive properties within the group. In one subject, a hyperopic shift (0.4 D) was observed, together with a more convex shape of the anterior lens surface and a decrease in the equivalent refractive index of the lens. Conclusions This study shows that hyperglycemia generally does not cause changes in the refractive properties of the healthy eye. Nevertheless, in one subject a hyperopic shift accompanied by a change in shape and refractive index of the lens was measured. This finding could provide an explanation for the mechanism underlying the refractive changes that are often observed during hyperglycemia.

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“…It has been suggested that the refractive changes observed at times of altered blood sugar levels could be related to both morphological and functional changes of the lens. In 1999 Furushima et al 3 studied the effect of the augmentation of glucose level in healthy volunteers by measuring their refractive system. He concluded that myopia in hyperglycaemia might be because of the thickening of the lens caused by a relaxation of the zonule of Zinn induced by ocular hypotension.…”

Section: Discussionmentioning

confidence: 99%

Refractory changes in hyperosmolar diabetic decompensation: when hyperglycaemia improves vision

2013

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Type 2 diabetes is a frequent condition in humans with about 350 million affected people. One of the complications is blindness caused by damage of the blood vessels in retina, cataract or glaucoma. But in an acute developing hyperglycaemia, changes in sugar level in blood modify the refraction in the eye. Thus people complain of blurred vision. We present a case of a patient with hypermetropia who reported quick amelioration of his vision as hyperglycaemia developed, because of myopisation.

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Changes in Refraction Caused by Induction of Acute Hyperglycemia in Healthy Volunteers

Cited by 29 publications

References 11 publications

Transient Hyperopia after Intensive Treatment of Hyperglycemia in Newly Diagnosed Diabetes

Transient Hyperopia after Intensive Treatment of Hyperglycemia in Newly Diagnosed Diabetes

Refractive properties of the healthy human eye during acute hyperglycemia

Refractory changes in hyperosmolar diabetic decompensation: when hyperglycaemia improves vision

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