Changes in reducing power profile of gastric juice in patients with active duodenal ulcer

Ligumsky, M.; Klar, Aharon; Siguencia, J.; Arnon, Ron; Gati, Irith; Kohen, Ron

doi:10.1016/j.biopha.2005.07.001

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…CV studies have been used for several medical conditions. These include abetalipoproteinemia [50], ageing [33,54,55], anchored temporomandibular joints [58], cancer [34], cerebral ischemia [48], colitis [42], CuZn-SOD deficiency [40], diabetes [46,60], dietary restriction [45], drug toxicity [66][67][68][69][70]77], duodenal ulcer [56], gastric dilatation [62], glycogen storage [62]. Since the majority of studies are limited in the scale, and the research conditions vary considerably, further research is needed to support the translation of the CV technique into full clinical use.…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant status from other body fluids including saliva [54], gastric juice [56], synovial fluid [58], skin secretions [55], cerebrospinal fluid (CSF) [53] and aqueous humour from the rabbit eye [39] has been measured. A range of specialized methods and collection protocols were used, including fine needle aspiration (synovial fluid and aqueous humour), gastroscopy (gastric juice) and collection wells (for skin secretion) are used.…”

Section: Other Sample Typesmentioning

confidence: 99%

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Cyclic Voltammetry in Biological Samples: A Systematic Review of Methods and Techniques Applicable to Clinical Settings

Wang

Bringans

Hickey

et al. 2021

Signals

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Oxidative stress plays a pivotal role in the pathogenesis of many diseases, but there is no accurate measurement of oxidative stress or antioxidants that has utility in the clinical setting. Cyclic Voltammetry is an electrochemical technique that has been widely used for analyzing redox status in industrial and research settings. It has also recently been applied to assess the antioxidant status of in vivo biological samples. This systematic review identified 38 studies that used cyclic voltammetry to determine the change in antioxidant status in humans and animals. It focusses on the methods for sample preparation, processing and storage, experimental setup and techniques used to identify the antioxidants responsible for the voltammetric peaks. The aim is to provide key information to those intending to use cyclic voltammetry to measure antioxidants in biological samples in a clinical setting.

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Section: Discussionmentioning

confidence: 99%

Section: Other Sample Typesmentioning

confidence: 99%

Cyclic Voltammetry in Biological Samples: A Systematic Review of Methods and Techniques Applicable to Clinical Settings

Wang

Bringans

Hickey

et al. 2021

Signals

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“…The tested serum homogenate was placed in a well containing three electrodes: a working electrode (glassy carbon 3.3 mm in diameter), a reference electrode (Ag/AgCl), and an auxiliary electrode (platinum wire). A constant 100-mV/s electric potential (up to 1.3 V) was applied towards the positive pole, inducing an anodic current (Chevion et al 2000;Ligumsky et al 2005). Each wave on the current reflects the activity strength of several compounds sharing a similar ability to donate an electron.…”

Section: Cyclic Voltammetrymentioning

confidence: 99%

“…1) indicates the presence of different types of low molecular weight antioxidants (LMWAs). The lower the oxidation potential is, the higher is the ability to donate electron(s) (Kohen et al 2000;Lenchner et al 2017;Ligumsky et al 2005). The concentration of the reducing agents is determined by the y-axis value (Ip) and is measured as the area under a certain wave curve (Ah) (Fig.…”

Section: Cyclic Voltammetrymentioning

confidence: 99%

Impacts of previous heatstroke history on physiological parameters eHSP72 and biomarkers of oxidative stress in military working dogs

Bruchim

Aroch

Nivy

et al. 2019

Cell Stress and Chaperones

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Heatstroke (HS) is an acute, progressive life-threatening emergency. Animals, including military working dogs (IDFMWD), rapidly activate cytoprotective processes, e.g., heat shock proteins (HSPs) and antioxidative molecules, in response to heat stress. We hypothesized that serum HSPs (eHSP72) and oxidative stress markers would differ in IDFMWD with a history of HS compared with controls and thus could be used to detect susceptibility to recurrent HS. eHSPs concentration, oxidative stress markers, and systemic physiological parameters were studied in dogs with and without histories of HS, undergoing indoor or outdoor training. Treadmill physical performance tests (PPTs) were conducted indoors at 22°C (groups C-I and HS-I) or outdoors under heat stress conditions of 36°C; 60% humidity (groups C-O and HS-O). Pre-, immediately post-, and 45 min post-PPT heart rate (HR), respiratory rate, and rectal temperature (T re ) were recorded in all dogs. Likewise, blood samples were collected and eHSP72, venous blood gas analysis, and lactate and creatine kinase activity (CK) were assayed. Serum uric acid (sUA) and total serum redox potential (TRP) were measured only in the indoor group. Immediately post-PPT under both environmental conditions, T re , HR, eHSP, sUA, and TRP (only measured in indoor PPT) significantly (P < 0.05) increased, whereas venous blood pH and bicarbonate decreased significantly (P < 0.05). Between groups comparisons demonstrated significant differences in basal HR and post-PPT T re immediately after outdoor PPT. eHSP72 induction, CK, sUA, and serum TRP remained significantly higher in the HS group during post-PPT recovery. Taken together, animals with a history of HS have different results, and this signature of previous HS may predict altered heat sensitivity.

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“…Physiologic antioxidant systems against these detrimental factors include antioxidant enzymes, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and free-radical scavengers. A few, such as carnosine, glutathione, and uric acid, are synthesized by living cells, whereas most others are derived from food [8]. Therefore, the imbalance between the detrimental and defensive factors appears to be critical in the development of mucosal lesions in the GI tract.…”

Section: Introductionmentioning

confidence: 99%

The role of L-carnitine in acetyl salicylic acid-induced acute gastric mucosal injury in rats

Uz¹,

Türkay²,

Uyar³

et al. 2017

Arch Med Sci Civil Dis

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A b s t r a c tIntroduction: The aim of this study was to determine the protective effects of L-carnitine on acetyl salicylic acid (ASA)-induced acute gastric mucosal injury through oxidant/antioxidant parameters and histopathological alterations in rat gastric tissues. Material and methods: Forty-two rats were randomly assigned to six groups: The control group received 1 mg/kg distilled water, while the other groups were pretreated with L-carnitine 50 mg/kg/day (LC), pantoprazole 40 mg/ kg/day (PPI), ASA + LC (50 mg/kg/day), and ASA + PPI (40 mg/kg/day), for 21 days, respectively. On day 23, gastric mucosal injury was induced by a single intragastric administration of 600 mg/kg aspirin in ASA, ASA + LC, and ASA + PPI groups. The animals were killed 60 min after the administration of aspirin. The stomach of each animal was removed. Gastric mucosal injury was scored histopathologically (ulcer score). Tissue catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities, and malondialdehyde (MDA) and nitric oxide (NO) levels were also measured. Results: The ulcer score increased significantly in the ASA group, but this increase was not significantly inhibited by the administration of L-carnitine (2.71 ±1.0 vs. 2.57 ±0.5, p = 0.965). The CAT and GSH-Px activities were significantly reduced, whereas MDA and NO levels were significantly increased in the ASA group. Pretreatment with L-carnitine did not alter CAT or GSH-Px activities, but reduced MDA and NO levels insignificantly (p = 0.204 and p = 0.277, respectively). Conclusions: Long-term administration of L-carnitine did not improve the oxidative and histological parameters of acute gastric mucosal injury induced by ASA.

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Changes in reducing power profile of gastric juice in patients with active duodenal ulcer

Cited by 6 publications

References 28 publications

Cyclic Voltammetry in Biological Samples: A Systematic Review of Methods and Techniques Applicable to Clinical Settings

Cyclic Voltammetry in Biological Samples: A Systematic Review of Methods and Techniques Applicable to Clinical Settings

Impacts of previous heatstroke history on physiological parameters eHSP72 and biomarkers of oxidative stress in military working dogs

The role of L-carnitine in acetyl salicylic acid-induced acute gastric mucosal injury in rats

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