“…Endometrial epithelial cells line the uterine lumen and glands, with the latter derived from the former [37, 38]. The endometrial epithelium undergoes dramatic cellular and molecular changes common to both mice and humans during the WOI, including adhesion mechanisms enabling the attachment of embryo to the luminal epithelium [39, 40], alterations in nuclear pore complex presentation [41], downregulation of the Serum and Glucocorticoid Regulated Kinase 1 (SGK1) [42], apoptotic cascade [43, 44], and expression of epithelial-specific receptivity markers [45]. The glandular epithelium further facilitates implantation via the production of Leukemia Inhibitory Factor (LIF), a critical factor in embryo-uterine communication during WOI [46–48].…”