Changes in rat respiratory system produced by exposure to exhaust gases of combustion of glycerol

Serra, Daniel Silveira; Evangelista, Janaína Serra Azul Monteiro; Zin, Walter A.; Leal-Cardoso, José Henrique; Cavalcante, Francisco Sales Ávila

doi:10.1016/j.resp.2017.04.001

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…The increase in the value of in groups CS and CS+TPM may represent greater narrowing of airway lumen or increased stiffness of smooth muscle of the airways in this groups compared to the CTRL group (SERRA et al, 2017). Our findings of histological analysis (Figure 6, insert) and lung parenchymal morphometry (Table 1, BCI) confirming narrower airways.…”

Section: Discussionmentioning

confidence: 50%

“…Regarding pulmonary response to challenge with MCh ( Figure 5), there was a statistically significant increase in CS and CS+TPM airway resistance compared to the CTRL group (Figure 3), evidencing a hyperresponsiveness of the smooth muscle of the airways. Hyperresponsiveness can also be attributed to the presence of inflammatory processes in the airways of these animals, where similar studies have reported airway hyperresponsiveness following exposure to cigarette smoke (LO et al, 2018) or pollutants (SERRA et al, 2017).…”

Section: Discussionmentioning

confidence: 73%

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Effects of Exposure to Total Particulate Matter of Cashew Nuts Shell in the Respiratory System of Mice with Chronic Obstructive Pulmonary Disease

2019

Aust. J. Basic & Appl. Sci.

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I. INTRODUCTION Global warming is one of the most debated environmental issues today, either because of the need for better knowledge on the subject, or for the analysis of its possible influences on life on earth. The increase in the temperature of the Earth's atmosphere coupled with the increase in the atmospheric levels of carbon dioxide (CO 2) are issues that need attention from the government and the scientific community, in an attempt to reverse the problems already present, and prevent them from increasing or become irreparable in the near future. One of the causes of global warming is the use of fossil fuels, a non-renewable resource. Faced with this problem, the search for renewable energies has grown, highlighting the use of residual biomass. Most households in China, India and sub-Saharan Africa use biomass fuel for cooking, and in rural areas of Latin America the proportion ranges from 30% to 75% (EZZATI; KAMMEN, 2002). Thus, approximately 3 billion people worldwide are exposed to biomass combustion gases compared to 1.1 billion people who smoke tobacco, suggesting that exposure to biomass smoke may be the most important overall risk factor for chronic obstructive pulmonary disease (COPD) (LOPEZ et al., 2006). As one of the largest agricultural producers in the world, Brazil has great capacity to generate energy from the residual biomass of sugarcane, rice, coffee straw and cashew nut shells (CNS). Despite the use of CNS in boiler feed for thermal energy generation in some industries, the adverse health effects of the exhaust gases from the combustion process of CNS are poorly studied, mainly in analyzes of exposure to people with pre-existing respiratory diseases such as emphysema, characterized as a COPD.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 73%

Effects of Exposure to Total Particulate Matter of Cashew Nuts Shell in the Respiratory System of Mice with Chronic Obstructive Pulmonary Disease

2019

Aust. J. Basic & Appl. Sci.

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“…Vehicle exhaust gas (EG) serves a principal role in air pollution and may induce various age-associated disorders, including cognitive dysfunction (1,2), metabolic dysregulation (3,4), cardiovascular disease (5,6) and cancer (7,8). Numerous studies have investigated the mechanisms underlying EG-associated disorders; DNA damage, epigenetic alterations, inflammation and oxidative stress have been identified to serve a role in these disorders (9–11).…”

Section: Introductionmentioning

confidence: 99%

Exposure to polycyclic aromatic hydrocarbons derived from vehicle exhaust gas induces premature senescence in mouse lung fibroblast cells

Yao

et al. 2019

Mol Med Report

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Long-term exposure to vehicle exhaust gas may lead to various age-associated disorders, including cardiovascular disease and cancer. Polycyclic aromatic hydrocarbons (PAHs) belong to an important class of carcinogens, which are released into the environment by vehicles and are detectable at high levels in Chinese urban areas. However, whether vehicle exhaust gas (EG), and in particular the PAHs derived from EG, are able to induce cell senescence remains unclear. In the present study, vehicle EG and pure PAHs were used as pollution sources to investigate the effects of long-term exposure to PAH on the cellular processes occurring in mouse lung fibroblast cells (mLFCs). Using cell proliferation and apoptosis assays, it was demonstrated that benzopyrene (BaP) suppressed the proliferation of mLFCs, and benzanthracene (BaA) and BaP induced cell apoptosis. Molecular analysis suggested that long-term exposure to BaA and BaP was able to increase the protein expression levels of p53, p21 and the apoptotic factors involved in the caspase cascade, including caspase-3 and −9. Notably, the present study suggested that PAH exposure was able to promote cell senescence in mLFCs by activating the ATM serine/threonine kinase/H2A histone family member X pathway. The present study may provide novel insights into the underlying mechanism of vehicle EG and PAHs in promoting the development of age-associated diseases.

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Floating Treatment Wetlands (FTWs) is an Innovative Approach for the Remediation of Petroleum Hydrocarbons-Contaminated Water

Mfarrej

Wang

Fahid

et al. 2022

J Plant Growth Regul

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Changes in rat respiratory system produced by exposure to exhaust gases of combustion of glycerol

Cited by 8 publications

References 32 publications

Effects of Exposure to Total Particulate Matter of Cashew Nuts Shell in the Respiratory System of Mice with Chronic Obstructive Pulmonary Disease

Effects of Exposure to Total Particulate Matter of Cashew Nuts Shell in the Respiratory System of Mice with Chronic Obstructive Pulmonary Disease

Exposure to polycyclic aromatic hydrocarbons derived from vehicle exhaust gas induces premature senescence in mouse lung fibroblast cells

Floating Treatment Wetlands (FTWs) is an Innovative Approach for the Remediation of Petroleum Hydrocarbons-Contaminated Water

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