Changes in rat adrenal cyclic nucleotides during normal and neoplastic growth

Stowe, Norma W.; Whitley, Thomas H.; Ney, Robert L.; Steiner, Alton L.

doi:10.1016/0304-4165(77)90290-2

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…DeRubertis et al (4) found no difference in levels between malignant human carcinoma of the colon and corresponding adjacent non-malignant tissues; whereas Stowe et al (7) found that an adrenocortical carcinoma o f the rat contained less cyclic GMP than normal adrenal gland. On the other hand, elevated tumour levels have also been reported (16,19).…”

Section: Discussionmentioning

confidence: 99%

Adenosine 3’ ,5’-Cyclic Monophosphate and Guanosine 3’,5’-Cyclic Monophosphate Levels in Tumour, Plasma and Urine during the Growth of a Fibrosarcoma in Hamsters

Latner¹,

Patterson²,

Turner³

1980

Pathobiology

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Levels of cyclic AMP and cyclic GMP were measured in tumours, plasmas, and urines from groups of hamsters at different times after implantation of a fibrosarcoma (of kidney cell origin) and in kidney cortices, plasmas and urines from healthy hamsters. Initially, tumour cyclic AMP levels were significantly lower than those in kidney cortex but this difference disappeared during the growth of the tumour. Plasma and urine cyclic AMP levels were significantly depressed during all phases of tumour growth. In general, cyclic GMP levels were unaffected by the presence of a tumour except when hamsters carried a very high tumour load.

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Section: Discussionmentioning

confidence: 99%

Adenosine 3’ ,5’-Cyclic Monophosphate and Guanosine 3’,5’-Cyclic Monophosphate Levels in Tumour, Plasma and Urine during the Growth of a Fibrosarcoma in Hamsters

Latner¹,

Patterson²,

Turner³

1980

Pathobiology

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“…The majority of previous animal and human cancer studies have reported that the cyclic-AMP level is either unchanged (Minton et al, 1976;Stowe et al, 1977) or elevated (Cohen and Chan, 1975;Minton et al, 1976;Guerinot et al, 1977) in tumours. One previous study (De Rubertis et al, 1976) on carcinoma of the human colon, however, reported that the cyclic-AMP content of tumours was lower than in adjacent normal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Cyclic Adenosine 3′, 5′ Monophosphate: A Possible Indicator of Premalignant Changes in the Large Bowel

Latner¹,

Turner²,

Tregoning

1979

Ann Clin Biochem

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Cyclic adenosine 3′, 5′ monophosphate (cyclic-AMP) has been estimated in mucosal biopsy samples removed from the descending colon and rectum at endoscopy to investigate the possibility of using this substance for monitoring pre-malignant changes in the large bowel. Four groups of patients have been studied: those with normal large bowel and rectal mucosa; those with non-malignant inflammatory bowel disease; those with an adenomatous polyp in the descending colon or sigmoid colon; and those with a rectal adenocarcinoma. No difference was found in the cyclic-AMP content of ‘normal’ rectal mucosa, ‘normal’ colonic mucosa, ‘diseased’ colonic mucosa, carcinomas, and uninvolved mucosa adjacent to the polyps. Less cyclic-AMP was found in the polyps than in adjacent uninvolved mucosa. Conversely, more cyclic-AMP was found in the carcinomas than in adjacent uninvolved mucosa. It is concluded that although cyclic-AMP may be a very useful parameter for delineating the extent of the disease in individual patients, it is not a suitable biochemical marker for the screening of neoplastic changes in the large bowel in the population as a whole.

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“…ACTH and some at least of its intracellular second messengers (e.g., the 3',5'-cyclic purine nucleotides) enhance mammalian adrenocortical growth in the whole animal (16,23,24). By sharp contrast, regulation of the proliferative activity of adrenal cortical cells in primary culture is still the object of a long-lasting controversy (3,10,(12)(13)(14)19,20).…”

Section: Introductionmentioning

confidence: 94%

Primary tissue culture of normal adult rabbit adrenocortical cells fromzonae fasciculata andreticularis

Menapace

Armato

1988

Journal of Tissue Culture Methods

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SUMMARY: Parenchymal cells isolated from decapsulated adrenal cortices of adult New Zealand white female rabbits by means of enzymatic {trypsin plus collagenase and hyaluronidase) predigestion at 37 ° C followed by mechanical dissociation within a calcium (Ca~+)-free buffer were set up in primary monolayer cultures onto very thin, porous polyethylene discs floating on the top of a growth medium contained inside the wells of a plastic cluster plate. In this setting, adrenal cortical cells, being at the interface between air and growth medium, benefit from both the respiratory and metabolic standpoint. Therefore, they fully respond to anabolic and growthpromoting stimuli which may increase cellular oxygen consumption significantly. Hence, this in vitro model is well suited for studying the fairly complex regulatory mechanisms of mammalian adult adrenal cortical cell proliferation and differentiation, as it allows one to take full advantage of an artificially controlled environment and of completely synthetic growth media.

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Changes in rat adrenal cyclic nucleotides during normal and neoplastic growth

Cited by 10 publications

References 14 publications

Adenosine 3’ ,5’-Cyclic Monophosphate and Guanosine 3’,5’-Cyclic Monophosphate Levels in Tumour, Plasma and Urine during the Growth of a Fibrosarcoma in Hamsters

Adenosine 3’ ,5’-Cyclic Monophosphate and Guanosine 3’,5’-Cyclic Monophosphate Levels in Tumour, Plasma and Urine during the Growth of a Fibrosarcoma in Hamsters

Cyclic Adenosine 3′, 5′ Monophosphate: A Possible Indicator of Premalignant Changes in the Large Bowel

Primary tissue culture of normal adult rabbit adrenocortical cells fromzonae fasciculata andreticularis

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