Changes in quality of life in patients with acromegaly after surgical remission &amp;mdash; A prospective study using SF-36 questionnaire

Shimizu, Fujio; Arimura, Hiroshi; Hirano, Hirofumi; Habu, Mika; Bohara, Manoj; Moinuddin, F M; Kinoshita, Yasuyuki; Arita, Kazunori

doi:10.1507/endocrj.ej16-0182

Cited by 20 publications

(21 citation statements)

References 25 publications

(19 reference statements)

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“…Tanemura et al [11] demonstrated that SF-36 scores initially decreased at 6 weeks after surgery and then increased at 6 months in patients with nonfunctioning adenomas. Another study showed that mental health status was elevated at 1 year after surgical remission in patients with GH-secreting adenomas [10]. In our study, at 3 months after surgery, the domains of PF and RP were even worse than the preoperative values in patients with nonfunctioning adenomas.…”

Section: International Journal Of Endocrinologycontrasting

confidence: 50%

“…High levels of prolactin (PRL) and 24 h urine free cortisol (24 h UFC) were associated with reduced quality of life in patients with prolactinomas and adrenocorticotropic hormone-(ACTH-) secreting adenomas [8]. After treatment, with the elimination of tumor mass effects and the mitigation of elevated hormone levels, the reduced quality of life in patients with pituitary adenomas was reported to be reversed in some literature [9][10][11]. However, systemic evaluation was not well achieved.…”

Section: Introductionmentioning

confidence: 99%

“…Tanemura et al [11] evaluated the health status of 30 patients with nonfunctioning macroadenomas using the SF-36 questionnaire and found that scores on the mental component were increased at 1 month after surgery and remained stable at 6 months, whereas the physical summary scores were initially decreased at 1 month and recovered to normal levels by 6 months after surgery. Fujio et al [10] demonstrated that mental condition improved at 1 year after surgery in patients with growth hormone-(GH-) secreting adenomas. ese studies provided an impression of the health status of patients with pituitary adenomas.…”

Section: Introductionmentioning

confidence: 99%

“…We were interested in whether these psychological factors had negative effects on patients' health status. In the literature, 6 weeks, 6 months, and 1 year after treatment are used as time points used to evaluate the reversibility of reduced health status [9][10][11], but the effects at 3 months after treatment, which is also an important time point for surgeons, have not been well evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors

Zhang

Guo

Wang

et al. 2020

International Journal of Endocrinology

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Purpose. To identify the characteristics of the physical and mental health status of patients with pituitary adenomas, explore the postoperative reversibility of impaired health status, and assess the impact of clinical characteristics, hormone levels, anxiety, depression, and disease stigma on health status. Methods. We prospectively enrolled 147 and 138 patients with nonfunctioning and secretory pituitary adenomas, respectively. Health status was evaluated in 8 domains using the 36-item Short-Form Health Survey before and 3 months after transsphenoidal surgery. The Self-Rating Anxiety Scale, the Self-Rating Depression Scale, and the Stigma Scale for Chronic Illness were used to assess the psychological status. Results. Compared with the healthy population reference values, general physical and mental health, social functioning, and role limitations due to physical and psychological health problems were all found to be significantly impaired in the adenoma patients. Health status was worse in patients with adrenocorticotropic hormone- (ACTH-) secreting and growth hormone- (GH-) secreting adenomas than in patients with nonfunctioning adenomas. Among the patients, 11.6% had anxiety and 30.9% had depression. Higher scores for anxiety, depression, and disease stigma; older age; higher body mass index; and tumor recurrence were independent risk factors for health status impairment in at least one domain. Physical function impairment and role limitations caused by physical health problems became worse after surgery, whereas the mental component of health status remained the same. Conclusion. Health status was impaired in patients with pituitary adenomas, especially secretory adenomas. Physical function and role limitations were worse 3 months after surgery than before surgery. Mental problems, old age, obesity, and tumor recurrence reduced health status.

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Section: International Journal Of Endocrinologycontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors

Zhang

Guo

Wang

et al. 2020

International Journal of Endocrinology

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“…There was also no significant difference in the exocrine function of the pancreas between the MID and ON groups of patients. Several studies verified the validity and reliability of the SF-36 questionnaire for the evaluation of QoL (29)(30)(31)(32)(33)(34)(35). The physical functioning aspect of the QoL questionnaire was improved during the first year of recovery from the acute necrotizing pancreatitis (36).…”

Section: Resultsmentioning

confidence: 88%

Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study

Zhang

Yang

et al. 2020

Exp Ther Med

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The present study aimed to determine whether a difference in pancreatic function and quality of life (QoL) is present between patients with infected pancreatitis necrosis (IPN) undergoing open necrosectomy (ON) and minimally invasive drainage (MID). The medical records of patients with IPN discharged from Jinling Hospital were retrospectively analyzed. Pancreatic function and QoL were compared between patients treated with ON and MID. Pancreatic endocrine and exocrine function were assessed using the oral glucose tolerance test and fecal elastase-1 (FE-1) test, respectively. The standard Short Form 36 health questionnaire was used to evaluate the QoL of patients. The analysis included 101 patients who underwent either ON (n=40, 39.6%) or MID (n=61, 60.4%). There were no significant differences in exocrine and endocrine pancreatic function between the two groups evaluated based on FE-1, fasting blood glucose, glycated hemoglobin and 2-h plasma glucose (P<0.05). The scores of the QoL questionnaire were significantly higher in patients treated with MID than in patients treated with ON, including the scores of general health perception (19.39±3.07 vs. 17.37±3.63, P=0.003), vitality (18.93±2.88 vs. 17.57±3.47, P=0.035), social role functioning (8.85±1.43 vs. 8.15±1.98, P=0.042), emotional role functioning (5.33±1.07 vs. 4.82±1.25, P=0.034), mental health (24.21±3.31 vs. 22.57±3.91, P=0.026) and the total QoL score (125.12±13.16 vs. 116.50±16.94, P=0.005). In conclusion, although the initial health of the patient may have influenced the treatment provided, patients with IPN who received MID achieved a better post-treatment QoL than those treated with ON. No significant differences between the two groups were observed regarding the endocrine and exocrine functions of the pancreas.

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Pituitary adenomas and neuropsychological status: a systematic literature review

et al. 2019

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Changes in quality of life in patients with acromegaly after surgical remission — A prospective study using SF-36 questionnaire

Cited by 20 publications

References 25 publications

Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors

Pre- and Postoperative Health Status of Patients with Nonfunctioning and Secretory Pituitary Adenomas and an Analysis of Related Factors

Comparison of pancreatic function and quality of life between patients with infected pancreatitis necrosis undergoing open necrosectomy and minimally invasive drainage: A long‑term study

Pituitary adenomas and neuropsychological status: a systematic literature review

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