Changes in Prostate Shape and Volume and Their Implications for Radiotherapy After Introduction of Endorectal Balloon as Determined by MRI at 3T

Heijmink, Stijn W. T. P. J.; Scheenen, Tom W. J.; Lin, Emile N.J.T. van; Visser, A.G.; Kiemeney, Lambertus A.; Witjes, J. Alfred; Barentsz, Jelle O.

doi:10.1016/j.ijrobp.2008.06.1491

Cited by 55 publications

(40 citation statements)

References 37 publications

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“…As previously stated, all 1 H-MRS data in our study were obtained without an endorectal coil. In addition to dramatically increased patient comfort, the protocol we applied also allowed for the use of the obtained anatomic MRI information in radiotherapy planning, because deformation of local prostate anatomy caused by endorectal coils is avoided (24). Visual analysis of contrast-enhanced MRI and PET/CT had the same agreement with cancer laterality based on biopsy results: 71%.…”

Section: Discussionmentioning

confidence: 80%

Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy

Jambor¹,

Borra²,

Kemppainen³

et al. 2010

J Nucl Med

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We assessed the ability of 11 C-acetate PET/CT, MRI, and proton MR spectroscopy ( 1 H-MRS) to image localized prostate cancer and detect its aggressiveness, using qualitative and quantitative approaches. Methods: Twenty-one patients with untreated localized prostate cancer, diagnosed using transrectal ultrasound-guided biopsy, were prospectively enrolled. Cancer laterality was based on the percentage of cancer and the highest Gleason score determined from biopsies. In addition to PET/CT, 3-dimensional 1 H-MRS of the entire prostate volume using a quantitative approach was performed. The imaging and histologic findings of 8 patients undergoing subsequent prostatectomy were compared on a sextant level. For each lobe and sextant, standardized uptake values (SUVs) and (choline 1 creatine 1 polyamines)-to-citrate (CCP/C) ratios were obtained from 11 C-acetate PET/CT and 1 H-MRS, respectively. The visual and quantitative findings on PET/CT and MRI data were compared with cancer laterality and aggressiveness based on the Gleason score and with prostate-specific antigen (PSA) velocity and international risk group classification. Results: The sensitivity, specificity, and accuracy, on a lobar level using visual analysis, of 11 C-acetate PET/CT were 80%, 29%, 71%, respectively, and 89%, 29%, 79%, respectively, using contrastenhanced MRI. The sensitivity and accuracy of 11 C-acetate PET/CT decreased to 64% and 63% and specificity increased to 62% when sextant analysis was performed. The agreement between prostate cancer laterality based on biopsy findings and visual interpretation of 11 C-acetate PET/CT and contrastenhanced MRI was similar at 71%. The mean SUV maximum and CCP/C maximum for the dominant tumor lesion were 5.5 and 1.48, respectively, and did not differ significantly from values in the nondominant lobe. The dominant-lesion SUVs or CCP/C values were not associated with histologically determined prostate cancer aggressiveness, nor did PSA velocity correlate with the SUV or CCP/C values from the entire gland.Conclusion: 11 C-acetate PET/CT, MRI, and 1 H-MRS enable detection of localized prostate cancer with comparable and limited accuracy but fail to provide information on cancer aggressiveness.

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Section: Discussionmentioning

confidence: 80%

Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy

Jambor¹,

Borra²,

Kemppainen³

et al. 2010

J Nucl Med

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“…In that study, the anteroposterior dimension was, on average, reduced by 15.7% with an endorectal coil. Such shape and volume changes may be infl uenced by water loss or physical vasoconstriction from the pressure of the infl ated endorectal balloon ( 36 ). Our results show an average underestimation across the fi ve volume measurements of 15.8% when compared with prostatectomy specimens, of the prostate for measuring ellipsoid diameters.…”

Section: Genitourinary Imaging: Computer-derived Prostate Volumes Fromentioning

confidence: 70%

“…Heijmink et al ( 36 ) showed a signifi cant difference in PV (mean 18% decrease) when MR images were acquired with an endorectal coil compared with those acquired with a body-array coil. In that study, the anteroposterior dimension was, on average, reduced by 15.7% with an endorectal coil.…”

Section: Genitourinary Imaging: Computer-derived Prostate Volumes Fromentioning

confidence: 99%

Automated Computer-derived Prostate Volumes from MR Imaging Data: Comparison with Radiologist-derived MR Imaging and Pathologic Specimen Volumes

Bulman¹,

Tóth²,

Patel

et al. 2012

Radiology

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Purpose:To compare prostate gland volume (PV) estimation of automated computer-generated multifeature active shape models (MFAs) performed with 3-T magnetic resonance (MR) imaging with that of other methods of PV assessment, with pathologic specimens as the reference standard. Materials and Methods:All subjects provided written informed consent for this HIPAA-compliant and institutional review board-approved study. Freshly weighed prostatectomy specimens from 91 patients (mean age, 59 years; range, 42-84 years) served as the reference standard. PVs were manually calculated by two independent readers from MR images by using the standard ellipsoid formula. Planimetry PV was calculated from gland areas generated by two independent investigators by using manually drawn regions of interest.Computer-automated assessment of PV with an MFA was determined by the aggregate computer-calculated prostate area over the range of axial T2-weighted prostate MR images. Linear regression, linear mixed-effects models, concordance correlation coeffi cients, and Bland-Altman limits of agreement were used to compare volume estimation methods. Results:MFA-derived PVs had the best correlation with pathologic specimen PVs (slope, 0.888). Planimetry derived volumes produced slopes of 0.864 and 0.804 for two independent readers when compared with specimen PVs. Ellipsoid formula-derived PVs had slopes closest to one when compared with planimetry PVs. Manual MR imaging and MFA PV estimates had high concordance correlation coefficients with pathologic specimens. Conclusion:MFAs with axial T2-weighted MR imaging provided an automated and effi cient tool with which to assess PV. Both MFAs and MR imaging planimetry require adjustments for optimized PV accuracy when compared with prostatectomy specimens.q RSNA, 2012

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“…Compared with 1.5T, imaging at high-field strengths such as 3T improves the resolution. As with 1.5T MRIs, ERCs cause significant changes in the prostate dimensions and a significant volume decrease, making image registration with the radiation treatment planning CT challenging [4]. Some investigators have suggested the resolution provided by 3T MRI without an ERC is as good as the 1.5T MRIs with an ERC [5][6][7][8].…”

Section: Mri Treatment Planningmentioning

confidence: 99%

Technological Advances in Radiation Therapy for Prostate Cancer

Choi

Hung

2010

Curr Urol Rep

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Radiation therapy (RT) for prostate cancer has made huge strides over the past two decades. The addition of image guidance has allowed radiation oncologists to ensure accurate delivery of increasingly precise radiation treatment plans using newer conformal therapy methods such as three-dimensional conformal RT, intensitymodulated RT, and proton beam RT. Regardless of the specific treatment technique, patients can depend on the treatment to target the moving prostate effectively while significantly sparing adjacent tissues, thereby reducing the morbidity of having to undergo prostate cancer therapy. This review summarizes the recent technical advances made in radiation dose delivery, including target volume definition, treatment planning, treatment delivery methods, and positional verification methods during RT.

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Changes in Prostate Shape and Volume and Their Implications for Radiotherapy After Introduction of Endorectal Balloon as Determined by MRI at 3T

Cited by 55 publications

References 37 publications

Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy

Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy

Automated Computer-derived Prostate Volumes from MR Imaging Data: Comparison with Radiologist-derived MR Imaging and Pathologic Specimen Volumes

Technological Advances in Radiation Therapy for Prostate Cancer

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Changes in Prostate Shape and Volume and Their Implications for Radiotherapy After Introduction of Endorectal Balloon as Determined by MRI at 3T

Cited by 55 publications

References 37 publications

Functional Imaging of Localized Prostate Cancer Aggressiveness Using 11C-Acetate PET/CT and 1H-MR Spectroscopy

Functional Imaging of Localized Prostate Cancer Aggressiveness Using 11C-Acetate PET/CT and 1H-MR Spectroscopy

Automated Computer-derived Prostate Volumes from MR Imaging Data: Comparison with Radiologist-derived MR Imaging and Pathologic Specimen Volumes

Technological Advances in Radiation Therapy for Prostate Cancer

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Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy

Functional Imaging of Localized Prostate Cancer Aggressiveness Using ¹¹C-Acetate PET/CT and ¹H-MR Spectroscopy