Changes in prognostic factors for patients with hepatocellular carcinoma underwent transarterial chemoembolization with the transition of the time: Child-Pugh class, Albumin-Bilirubin grade, and then

Impact of body composition on the prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization: A systematic review and meta-analysis

“…The clinical indicators frequently identified in the reviewed studies included tumor -related factors (e.g., tumor size and number, the Tumor, Node, Metastasis stage, vascular invasion and the alpha-fetoprotein level), liver function-related factors (such as albumin and bilirubin level, Child-Pugh grade), and a combination of these two (like BCLC stage). These findings were consistent with previous research [ 9 , 12 ]. Except these, treatment related factors have also shown to be closely correlated with the prognosis after TACE treatment, including number of TACE sessions [ 55 ], and response to TACE [ 56 ].…”

“…However, the treatment response and outcomes after TACE treatment vary substantially given that the indications are heterogeneous and patients with BCLC stage B may have different tumor burdens, liver function, and physical status. [ 9 , 10 ] Several risk factors have been identified for a poor prognosis in patients undergoing TACE, including the alpha-fetoprotein level, tumor number and size, tumor thrombus, number of lobar involvements, Model of End-Stage Liver Disease score, and tumor imaging features (such as irregular margin and internal arteries). [ 9 , 11 , 12 ] Based on these risk factors, several clinical models have been proposed to predict TACE outcomes, such as the hepatoma arterial-embolization prognostic score [ 13 ], the “six-and-twelve” score [ 14 ], and the CITRUS-MICAN score.…”

“…[ 9 , 10 ] Several risk factors have been identified for a poor prognosis in patients undergoing TACE, including the alpha-fetoprotein level, tumor number and size, tumor thrombus, number of lobar involvements, Model of End-Stage Liver Disease score, and tumor imaging features (such as irregular margin and internal arteries). [ 9 , 11 , 12 ] Based on these risk factors, several clinical models have been proposed to predict TACE outcomes, such as the hepatoma arterial-embolization prognostic score [ 13 ], the “six-and-twelve” score [ 14 ], and the CITRUS-MICAN score. [ 15 ] Nevertheless, these models only focus on tumor and liver function while overlooking the impact of the systemic prognostic factor on outcomes of TACE treatment.…”

Unsupervised Machine Learning of MRI Radiomics Features Identifies Two Distinct Subgroups with Different Liver Function Reserve and Risks of Post-Hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

“…The ALBI score, which is a novel parameter proposed in recent years, consists of two common liver function biochemical tests: serum albumin and bilirubin [ 44 ]. It has proven to be a reliable and accurate alternative to the Child–Pugh system in the objective evaluation of liver function in HCC patients [ 45 ]. The newly updated Barcelona Clinic liver cancer (BCLC) staging system has incorporated the ALBI score for objective hepatic reserve estimation and prognosis prediction [ 46 ].…”

Geriatric Nutritional Risk Index Predicts Prognosis in Hepatocellular Carcinoma After Hepatectomy: A Propensity Score Matching Analysis

“…Chronic hepatitis or liver cirrhosis is usually present in the background of HCC and may result in malnutrition in these patients. Some studies have reported that malnutrition negatively impacts postoperative complications and cancer prognosis 2 .…”