Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man.

Hultborn, Hans; Meunier, Sabine; Pierrot-Deseilligny, E; Shindo, Masaomi

doi:10.1113/jphysiol.1987.sp016681

Cited by 422 publications

(254 citation statements)

References 24 publications

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“…Previous human studies have demonstrated diverse excitatory inputs onto Ia and presynaptic inhibitory interneurons in man, with their inhibitory actions to decrease or to increase depending on the direction of the movement (Petersen et al 1999;Morita et al 2001;Kagamihara 1993, Pierrot-Deseilligny 1997;Hultborn et al 1987). These studies along with our findings suggest that the strength of reciprocal Ia and presynaptic inhibition is influenced by afferents of distal and proximal muscles and that some heteronymous connections postulated in healthy subjects (Meunier et al 1990) are preserved following SCI.…”

Section: Hip-induced Modulation Of Spinal Inhibitory Mechanismssupporting

confidence: 72%

Effects of hip joint angle changes on intersegmental spinal coupling in human spinal cord injury

Knikou

2005

Exp Brain Res

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Pathological expression of movement and muscle tone in human upper motor neuron disorders has been partly associated with impaired modulation of spinal inhibitory mechanisms, such as reciprocal or presynaptic inhibition. In addition, input from specific afferent systems contributes significantly to spinal reflex circuits coupled with posture or locomotion. Accordingly, the objectives of this study were to identify the involved afferents and their relative contribution to soleus H-reflex modulation induced by changes in hip position, and to relate these effects with activity of spinal interneuronal circuits. Specifically, we investigated the actions of group I synergistic and antagonistic muscle afferents (e.g. common peroneal nerve, CPN; medial gastrocnemius, MG) and tactile plantar cutaneous afferents on the soleus H-reflex during controlled hip angle variations in 11 motor incomplete spinal cord injured (SCI) subjects. It has been postulated in healthy subjects that CPN stimulation evokes an inhibition on the soleus H-reflex at a conditioning test (C-T) interval of 2-4 ms. This short latency reflex depression is caused mainly by activation of the reciprocal Ia inhibitory pathway. At longer C-T intervals (beyond 30 ms) the soleus H-reflex is again depressed, and is generally accepted to be caused by presynaptic inhibition of soleus Ia afferents. Similarly, MG nerve stimulation depresses soleus H-reflex excitability at the C-T interval of 6 ms, involving the pathway of non-reciprocal group I inhibition, while excitation of plantar cutaneous afferents affects the activity of spinal reflex pathways in the extensors. In this study, soleus H-reflexes recorded alone or during CPN stimulation at either short (2, 3, 4 ms) or long (80, 100, 120 ms) C-T intervals, and MG nerve stimulation delivered at 6 ms were elicited via conventional methods and similar to those adopted in studies conducted in healthy subjects. Plantar skin conditioning stimulation was delivered through two surface electrodes placed on the metatarsals at different C-T intervals ranging from 3 to 90 ms. CPN stimulation at either short or long C-T intervals and MG nerve stimulation resulted in a significant facilitation of the soleus H-reflex, regardless of the hip angle tested. Plantar skin stimulation delivered with hip extended at 10° induced a bimodal facilitation reflex pattern, while with hip flexed (10°, 30°) the reflex facilitation increased with increments in the C-T interval. This study provides evidence that in human chronic SCI, classically key inhibitory reflex actions are switched to facilitatory, and that spinal processing of plantar cutaneous sensory input and actions of synergistic/antagonistic muscle afferents interact with hip proprioceptive input to facilitate soleus H-reflex excitability. These actions might be associated with the pathological expression of neural control of movement in individuals with SCI, and potentially could be considered in rehabilitation programs geared to restore sensorimotor function in these patien...

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Section: Hip-induced Modulation Of Spinal Inhibitory Mechanismssupporting

confidence: 72%

Effects of hip joint angle changes on intersegmental spinal coupling in human spinal cord injury

Knikou

2005

Exp Brain Res

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“…This stimulation, which can cause kinesthetic illusions of muscle lengthening, has also been demonstrated to have longer term effects after removal of the vibration (Cordo et al, 1995, Shinohara, 2005, Wierzbicka et al, 1998. These effects include increases in the discharge threshold of the Ia afferents and inhibition of Ia terminals (Hayward et al, 1986, Hultborn et al, 1987, Shinohara, 2005. Such vibration has been shown, in the ankle, to decrease the amplitude of H reflexes in both the stimulated and synergistic muscles (Curtis and Eccles, 1960, Hultborn et al, 1987, Shinohara, 2005.…”

Section: Discussionmentioning

confidence: 97%

“…These effects include increases in the discharge threshold of the Ia afferents and inhibition of Ia terminals (Hayward et al, 1986, Hultborn et al, 1987, Shinohara, 2005. Such vibration has been shown, in the ankle, to decrease the amplitude of H reflexes in both the stimulated and synergistic muscles (Curtis and Eccles, 1960, Hultborn et al, 1987, Shinohara, 2005. Such vibration exposure has been demonstrated to alter overall joint dynamics as well, with vibration of the ankle tendons, for example, altering center of pressure trajectories in standing sway after vibration exposure (Wierzbicka et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Whole-body vibration alters proprioception in the trunk

Li¹,

Lamis²,

Wilson³

2008

International Journal of Industrial Ergonomics

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Abstract:Occupational whole body vibration has long been associated with low back injuries.However, the mechanism of these injuries is not well understood. In this paper, the effect of whole body vibration on proprioception and dynamic stability was examined. Subjects exposed to 20 minutes of vertical, seated, whole body vibration were found to have a 1.58 fold increase in position sense errors after vibration relative to controls exposed to 20 minutes of the same seated posture without vibration exposure. To understand the potential effect of a sensory loss on dynamic low back stability a lumped parameter model of the trunk and neuromotor response was created. Using this model, an increase in the threshold of the sensory system was predicted to increase trunk flexion and delay neuromotor response with a sudden, unexpected perturbation. These predictions were demonstrated in a second experiment where subjects exhibited both an 11.9% increase in trunk flexion and an 11.2% increase in time to peak paraspinal muscle response (measured using integrated electromyographic activity) after exposure to 20 minutes of vertical, seated, whole body vibration.

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“…Consequently, testing PAD pathways by using sensory volleys during movements and posture in healthy or neurologically injured humans may monitor only part of the ongoing presynaptic inhibition (Butchart et al, 1993;Calancie et al, 1993;Earles et al, 2001;Bove et al, 2003;Kitano et al, 2009;Roche et al, 2011). Sensory stimulation studies should be complemented with other techniques, such as changes in heteronymous Ia facilitation (Hultborn et al, 1987a(Hultborn et al, , 1987b to evaluate the overall level of ongoing presynaptic inhibition (Faist et al, 1994(Faist et al, , 1996Morita et al, 1995Morita et al, , 2000Baudry et al, 2011).…”

Section: Presynaptic Inhibition and Movements In Humansmentioning

confidence: 99%

Independent Control of Presynaptic Inhibition by Reticulospinal and Sensory Inputs at Rest and during Rhythmic Activities in the Cat

2013

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To be functionally relevant during movement, the transmission from primary afferents must be efficiently controlled by presynaptic inhibition. Sensory feedback, central pattern generators, and supraspinal structures can all evoke presynaptic inhibition, but we do not understand how these inputs interact during movement. Here, we investigated the convergence of inputs from the reticular formation and sensory afferents on presynaptic inhibitory pathways and their modulation at rest and during two fictive motor tasks (locomotion and scratch) in decerebrate cats. The amplitude of primary afferent depolarization (PAD), an estimate of presynaptic inhibition, was recorded in individual afferents with intra-axonal recordings and in a mix of afferents in lumbar dorsal rootlets (dorsal root potential [DRP]) with bipolar electrodes. There was no spatial facilitation between inputs from reticulospinal and sensory afferents with DRPs or PADs, indicating an absence of convergence. However, spatial facilitation could be observed by combining two sensory inputs, indicating that convergence was possible. Task-dependent changes in the amplitude of responses were similar for reticulospinal and sensory inputs, increasing during fictive locomotion and decreasing during fictive scratch. During fictive locomotion, DRP and PAD amplitudes evoked by reticulospinal inputs were increased during the flexion phase, whereas sensory-evoked DRPs and PADs showed maximal amplitude in either flexion or extension phases. During fictive scratch, the amplitudes of DRPs and PADs evoked by both sources were maximal in flexion. The absence of spatial facilitation and different phase-dependent modulation patterns during fictive locomotion are consistent with independent presynaptic inhibitory pathways for reticulospinal and sensory inputs.

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Changes in presynaptic inhibition of Ia fibres at the onset of voluntary contraction in man.

Cited by 422 publications

References 24 publications

Effects of hip joint angle changes on intersegmental spinal coupling in human spinal cord injury

Effects of hip joint angle changes on intersegmental spinal coupling in human spinal cord injury

Whole-body vibration alters proprioception in the trunk

Independent Control of Presynaptic Inhibition by Reticulospinal and Sensory Inputs at Rest and during Rhythmic Activities in the Cat

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