Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years

Abstract

OS for LGG has improved over the past 50 years, despite similar rates of progression. In the modern cohort, more patients are receiving a diagnosis of oligodendroglioma and are undergoing extensive resections, both of which are associated with improvements in OS. Because of risk factor stratification by clinicians, the use of PORT has decreased and is primarily being used to treat high-risk tumors in modern patients.

Deficiency of very large G-protein-coupled receptor-1 is a risk factor of tumor-related epilepsy: a whole transcriptome sequencing analysis

“…The present study showed that patients with tumors involving the cortex were more likely to have epileptic seizures. The result of the multivariate survival analysis shows that VLGR1 expression is not a prognostic factor for PFS in patients with LGGs, nor age, sex, seizures and cortex involvement, which was consistent with the findings in previous studies [50,55].…”

“…It has been suggested that perturbation of these closely related processes can lead to certain forms of epilepsies [49]. Moreover, genes associated with synaptic transmission were also considered to play a role in the pathogenesis of tumor-related epilepsy [14,50]. Thus, it is conceivable that VLGR1 drives epileptogenesis in patients with LGGs through influencing synaptic transmission.…”

Glioma cell migration and invasion as potential target for novel treatment strategies

“…The concept of glioma cell migration includes several reasons for an elevated migrational behavior. Most notably the depletion of oxygen and nutrition as a result of an increased cell density in the growing tumor consequentially leads to intracellular metabolic stress (1). Focal adhesions (FA, 2) are large complexes consisting of multiple proteins with numerous functions.…”

“…of the last century [1]. While in the pre-MRI era, seizures and headache were significantly more frequently reported as primary symptoms in case of diffuse gliomas, sensory and motor symptoms were more commonly encountered afterwards.…”

“…Despite maximum treatment including neurosurgical resection followed by radioand chemotherapy, the median overall survival is still less than 1 year in population-based patient cohorts suffering from GBM, while in selected patients significantly higher survival rates could be achieved [7,8]. In low-grade diffuse gliomas, the overall survival could be increased from 6 to 9 years within the last decades and progression-free survival from 4.4 to 8 years [1].…”