Changes in Power Spectra of Electroencephalograms During Anesthesia With Fluroxene, Methoxyflurane and Ethrane

Aj, Bart; Homi, John; Hw, Linde

doi:10.1213/00000539-197101000-00011

Cited by 41 publications

(8 citation statements)

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“…Bart et al. () report that, in humans, higher frequency activity persists with increasing methoxyflurane concentration, and that the progressive increase in power associated with increasing anaesthetic concentration is less marked for methoxyflurane than for other inhalant anaesthetics. Our result for chickens may be consistent with this finding in humans.…”

Section: Discussionmentioning

confidence: 99%

Effects of isoflurane, sevoflurane and methoxyflurane on the electroencephalogram of the chicken

McIlhone

Beausoleil

Johnson

et al. 2014

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

Effects of isoflurane, sevoflurane and methoxyflurane on the electroencephalogram of the chicken

McIlhone

Beausoleil

Johnson

et al. 2014

Veterinary Anaesthesia and Analgesia

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“…7 Linde and colleagues used the spectrum—the decomposition of the electroencephalogram signal into the power in its frequency components—to show that under general anesthesia the electroencephalogram was organized into distinct oscillations at particular frequencies. 8,9 Bickford and colleagues introduced the compressed spectral array or spectrogram to display the electroencephalogram activity of anesthetized patients over time as a three-dimensional plot (power by frequency versus time). 10,11 Fleming and Smith devised the density-modulated or density spectral array, the two-dimensional plot of the spectrogram for this same purpose.…”

Section: The Electroencephalogram and Brain Monitoring Under General mentioning

confidence: 99%

Clinical Electroencephalography for Anesthesiologists

et al. 2015

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The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce distinct brain states that are readily visible in the electroencephalogram. We present a two-part review to educate anesthesiologists on use of the unprocessed electroencephalogram and its spectrogram to track the brain states of patients receiving anesthesia care. Here in Part I, we review the biophysics of the electroencephalogram, and the neurophysiology of the electroencephalogram signatures of three intravenous anesthetics: propofol, dexmedetomidine and ketamine; and four inhaled anesthetics: sevoflurane, isoflurane, desflurane and nitrous oxide. Later in Part II, we discuss patient management using these electroencephalogram signatures. Use of these electroencephalogram signatures suggests a neurophysiologically-based paradigm for brain-state monitoring of patients receiving anesthesia care.

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“…Abnormal movements consisting of twitching of individual muscle groups, and even tonic-clonic activity, were frequently observed during the early clinical evaluation of enflurane (17,18). Subsequent EEG recordings in normal patients demonstrated epileptiform activity (19,20) and grand ma1 seizure patterns (21) ( Table 2). These findings with enflurane have also been confirmed in patients with temporal lobe epilepsy during both electrocortico- In ten healthy volunteers, grand ma1 seizure patterns were precipitated by auditory, visual, and tactile stimulation at end-tidal enflurane concentrations of 3%-6% (26).…”

Section: Inhala Tion Anesthetics Volatile Agentsmentioning

confidence: 99%

Pro-and Anticonvulsant Effects of Anesthetics (Part I)

Modica

Tempelhoff

White

1990

Anesthesia & Analgesia

148

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Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual patient's responses to anesthetic and analgesic drugs. In addition, variations in the responsiveness of inhibitory and excitatory neurons to the central depressant effects of these drugs could also explain these apparently conflicting data. Depending on the brain concentration, centrally active drugs may produce differing effects on the CNS inhibitory and excitatory neurotransmitter systems. The availability of increasingly powerful magnetic resonance imaging techniques to provide noninvasive information about tissue chemistry (e.g., neurotransmitters and citric acid cycle metabolites) and positron emission tomography to noninvasively evaluate CNS drug-receptor interactions should lead to a more in-depth understanding of the in vivo effects of anesthetics and analgesics on the CNS. In the second part of this review article, we discuss the pro- and anticonvulsant effects of the sedative-hypnotics, local anesthetics, and other anesthetic adjuvant drugs.

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Changes in Power Spectra of Electroencephalograms During Anesthesia With Fluroxene, Methoxyflurane and Ethrane

Cited by 41 publications

References 0 publications

Effects of isoflurane, sevoflurane and methoxyflurane on the electroencephalogram of the chicken

Effects of isoflurane, sevoflurane and methoxyflurane on the electroencephalogram of the chicken

Clinical Electroencephalography for Anesthesiologists

Pro-and Anticonvulsant Effects of Anesthetics (Part I)

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