2018
DOI: 10.1037/ccp0000292
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Changes in posttraumatic stress disorder (PTSD) and depressive symptoms over the course of prolonged exposure.

Abstract: The relationship between reductions in PTSD and depression during PE is transactional. Regardless of whether PTSD or depression decreases first, reduction in the other symptom cluster is likely to follow. (PsycINFO Database Record

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Cited by 31 publications
(17 citation statements)
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References 54 publications
(108 reference statements)
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“…Still, PE falls short in measures of treatment efficiency, since approximately one third of patients failed to respond to treatment (Popiel et al, 2015) and retained their PTSD diagnosis (Foa et al, 1999; Zoellner et al, 2019). Moreover, PE has a high burden of psychological demands on the patients (Kaysen et al, 2019), so therapy dropout rates can reach more than 30 % (Brown et al, 2018; Zoellner et al, 2019). Overall, evidence indicates that existing treatment options for PTSD are ineffective for a significant subset of patients who enter clinical trials, highlighting the need for new and improved treatments.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Still, PE falls short in measures of treatment efficiency, since approximately one third of patients failed to respond to treatment (Popiel et al, 2015) and retained their PTSD diagnosis (Foa et al, 1999; Zoellner et al, 2019). Moreover, PE has a high burden of psychological demands on the patients (Kaysen et al, 2019), so therapy dropout rates can reach more than 30 % (Brown et al, 2018; Zoellner et al, 2019). Overall, evidence indicates that existing treatment options for PTSD are ineffective for a significant subset of patients who enter clinical trials, highlighting the need for new and improved treatments.…”
Section: Discussionmentioning
confidence: 99%
“…Still, ET falls short in measures of treatment efficiency, since approximately one third of patients failed to respond to treatment (Popiel et al, 2015) and retained their PTSD diagnosis (Foa et al, 1999; Zoellner et al, 2019). Combined with the emotionally challenging nature of psychotherapy, this contributes to significant dropout rates registered for ET (Brown et al, 2018; Zoellner et al, 2019). Because of these limitations, researchers have developed a therapeutic approach in which ET is coupled with pharmacotherapy in an attempt to improve therapy outcomes among subjects with modest response to it.…”
Section: Introductionmentioning
confidence: 99%
“…In several studies focused on older adults with PTSD, some of the participants (58%-77%) were still qualified for diagnosis, whereas more than half did not feel a reduction in symptom severity [19][20][21][22]. There is also some evidence that prolonged exposure therapy can exaggerate symptoms in a fraction of PTSD participants [23]. Of course, there have been many far-reaching studies from this past decade which indicate that with refinement, prolonged exposure therapy is more effective in treating PTSD, across a wide range of traumas and comorbid symptoms, compared to traditional cognitive behavioral therapy (see Foa and McLean [13] for an in-depth review).…”
Section: Pavlovian Fear Conditioning and Exposure Therapiesmentioning
confidence: 99%
“…It is characterized by distressed recollection of the traumatic events and hyper-vigilance [2]. PTSD is highly comorbid and approximately half of the individuals with PTSD usually report comorbid depressive symptoms across various epidemiological samples [3]. PTSD is manageable either with the pharmacotherapeutic or psychotherapeutic treatments, however, practitioners sometimes prefer psychotherapy, especially if the pharmacotherapy is not effective [4].…”
Section: Introductionmentioning
confidence: 99%