Changes in platelet functional parameters and CD62 P expression in liver cirrhosis

Guan, Xizhou; Guanping, C; Yang, Fenghua; Jiayin, W

doi:10.4314/ahs.v13i4.31

Cited by 15 publications

(15 citation statements)

References 13 publications

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“…Mean platelet count in cirrhosis and control group (100×10 9 /L versus 290×10 9 /L, p value <0.05) in our study was lower than the Chinese study by Xianghoung et al (43×10 9 /L versus 95×10 9 /L, p value <0.05). 8 9 The data from South Indian blood donors are comparable to our data for normal control population. Platelet count was lower and MPV was higher in the north-eastern population and the reason is attributed to existence of Harris platelet syndrome, a well-known entity in northeast and it is the most common cause for inherited giant platelet disorder also.…”

Section: Discussionsupporting

confidence: 77%

“…12 Xianghoung et al found that MPV and CD62P-a granular protein on platelet surface and marker of activation were higher in liver cirrhosis patients than in the control group. 8 Increase in CD62P and MPV could cause hypersplenism and can destroy platelets. Several other markers of platelet activation like serum beta-thromboglobulin, platelet factor 4 alphagranule contents, P-selectin expression on resting platelets was considerably higher in cirrhosis patients.…”

Section: Discussionmentioning

confidence: 99%

“…A decreased MPV may be related to the presence of endotoxins and suppression of bone marrow , as well as to endotoxins and increased immunoglobulin, both having the ability to induce sustained platelet activation, thereby leading to the release of active compounds that cause granular exhaustion, platelet shrinkage, and decreased preservation and resulting low MPV. 8 Low values of MPV are obtained in hypersplenism, myeloproliferative disorders, sepsis and postchemotherapy. 24 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative study of platelet indices in cirrhosis, cirrhosis with sepsis and normal population

Mukker¹,

Haridas²,

Kallinkeel³

et al. 2016

Int J Res Med Sci

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Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury that leads to portal hypertension and end stage liver disease. Abnormal hematological indices (HI) are common in cirrhosis with a prevalence ranging from 6% to 77% in various studies. 1 Platelets are non-nucleated cell fragments derived from megakaryocytes, most often present in the bone marrow. Studies show that platelets produced from megakaryocytes present in the microvasculature is governed by circulatory forces. 2 Thrombocytopenia was the most common and earliest HI abnormality to develop in cirrhosis. 1 MPV is the measure of average size of platelets in circulation, and PDW is an index reflecting the heterogeneity of platelets. Platelet activation leads to changes in platelet shape with increase in platelet size ABSTRACT Background: Platelet indices are the first hematologic indices to be affected in cirrhosis. Cirrhosis patients are particularly susceptible to bacterial infections. The incidence of sepsis in cirrhosis is estimated to be at least 30-50% of hospital admissions. Sepsis also causes alterations in platelet indices. We studied and compared the platelet indices namely platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and platecrit in cirrhosis, cirrhosis with sepsis and normal control population. Methods: This observational study included forty cirrhosis, forty three cirrhosis with sepsis and sixty one controls. Platelet indices were reviewed and compared between the groups and correlation of platelet indices with CTP score, MELD, platelet count and spleen size was also evaluated. Results: Platelet indices were significantly altered in cirrhosis compared to normal population. MPV and PDW were significantly higher in cirrhosis compared to control population. Platelet count and platecrit were significantly lower in cirrhosis compared to control population. CTP score and MELD showed significant positive correlation with MPV and platelet count showed significant negative correlation with PD. Sepsis in cirrhosis was associated with significant decrease in platelet count and platecrit but caused significant increase in PDW compared to cirrhosis without sepsis. Cirrhosis with sepsis group had four patients with variceal bleeding with significantly higher mean PDW(19%) and significantly lower mean platecrit (0.04) compared to nonbleeding group (p value <0.05). Conclusions: Platelet indices are useful parameters in cirrhosis. Other than platelet count, PDW and platecrit are useful indices to be monitored in cirrhosis with sepsis.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of platelet indices in cirrhosis, cirrhosis with sepsis and normal population

Mukker¹,

Haridas²,

Kallinkeel³

et al. 2016

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…In a study by Xianghoung et al, mean platelet count among cirrhosis was lower when compared to our study (43×109 /L), p value <0.05). 12 In another study by Murali et al, they found significant correlation between Platelet and alcoholic liver cirrhosis with the median platelet count of less than 70x103cells/mm 3 was effective for ruling in alcoholic cirrhosis and a platelet count greater than 200x103 cells/mm 3 significantly decreased the likelihood of having cirrhosis. 13 A recent meta-analysis by Udell et al, identified thrombocytopenia as the single most important laboratory test for identifying cirrhosis of varying etiologies.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis

Feros

Lokesh

2019

Int J Adv Med

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Background: Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic long lasting injury. Liver biopsy is considered as a gold standard for the diagnosis of cirrhosis and has many problems like bleeding, infective peritonitis which limit use of liver biopsies in all patients.Methods: A comparative study was done (90 cases and 90 controls) who fulfilled the inclusion criteria in a tertiary center.Results: The present study was conducted using a total of 180 participants, 90 USG diagnosed cases of liver cirrhosis was compared with 90 healthy controls. The mean AST level in the cirrhosis was 66.50±27.06 as compared to 21.26±6.52 in controls which was statistically significant. In this study the sensitivity and specificity of APRI was found to be 100.0% and 84.44% respectively, and the positive and negative predictive values were 86.54% and 100% respectively with significantly Area under the curve (AUC) (0.999, P>0.01).Conclusions: A simple index like Aspartate platelet ratio index, consisting of 2 readily available laboratory results (AST level and platelet count), can predict cirrhosis with a high degree of accuracy.

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“…This is consistent with the result of a decreased blood platelet count in patients with RT mutations, because patients with liver fibrosis are always associated with dramatically decreased blood platelet count. 34 The mechanistic explanation for the relationship between RT mutations and liver fibrosis is presently unclear. It could be speculated that the appearance of RT mutations was a sign of the interaction history between the HBV and host immune response in the liver environment.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B

et al. 2017

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Background. Mutations in reverse transcriptase (RT) of the hepatitis B virus (HBV) are demonstrated to be strongly associated with nucleos(t)ide analog resistance, which is supposed to be the biggest obstacle during the long-term anti-viral treatment of chronic hepatitis B. However, the presence of RT mutations in treatment-naïve chronic hepatitis B patients and its clinical significance are not well known.

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Changes in platelet functional parameters and CD62 P expression in liver cirrhosis

Cited by 15 publications

References 13 publications

Comparative study of platelet indices in cirrhosis, cirrhosis with sepsis and normal population

Comparative study of platelet indices in cirrhosis, cirrhosis with sepsis and normal population

Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis

Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B

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