Changes in Plasma or Serum Concentrations of Magnesium, Iron and Thyroxine, in Leukocyte Triglyceride Content, and in Peritoneal Fluid Protein Concentration in Rabbits Injected with Adrenocorticotropin or<i>β</i>Melanocyte-Stimulating Hormone

Akgün, Suat; Rudman, Daniel; Wertheim, Arthur R.

doi:10.1210/endo-84-2-347

Cited by 11 publications

(7 citation statements)

References 2 publications

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“…The melanocortin system colocalizes with iron rich pigmented nuclei in the brain and dopaminergic A11 neurons in brain and spinal cord 11, 27, 33. Melanocortin release and expression are regulated by dopamine,28, 30, 31 while their binding may modulate iron levels in serum and brain 29, 33. Undoubtedly, further investigation is needed to clarify interactions among these diverse systems.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased iron stores and iron‐depleted neuromelanin may reflect quantitative or qualitative alterations in either ACTH or α‐MSH; conversely primary iron abnormalities may cause alterations in ACTH and/or α‐MSH expression. More acutely, ACTH when administered in rabbit causes a decrease in serum iron and iron‐binding capacity 29…”

mentioning

confidence: 99%

“…Current understanding about RLS pathogenesis surrounds the dopaminergic and iron‐handling systems. ACTH and α‐MSH each have physiologic associations with dopamine and iron 28, 29. Dopamine is involved in the regulation of α‐MSH and ACTH.…”

mentioning

confidence: 99%

“…ACTH and a-MSH each have physiologic associations with dopamine and iron. 28,29 Dopamine is involved in the regulation of a-MSH and ACTH. In rat hypothalamus, dopamine-2-receptor blockade results in increased mRNA levels of POMC, 28 the precursor for both ACTH and a-MSH, suggesting that dopamine inhibits ACTH and a-MSH expression.…”

mentioning

confidence: 99%

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α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?

Koo

Feng

Dostal³

2008

Movement Disorders

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Alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) possess properties suggesting that they may be involved in the pathogenesis of restless legs syndrome (RLS). We sought to determine if alpha-MSH and ACTH when administered centrally in rat recapitulate features reminiscent of RLS: increased activity, sleep fragmentation, and periodic movements during sleep. Rats were instrumented with electroencephalography, electromyography, and intracerebral cannulae and recorded for the measurement of sleep, periodic movements, and behavior following intracerebroventricular administration of alpha-MSH, ACTH, or saline. Studied behavior included grooming, locomotion, and rearing during wake and limb movements during sleep. Vigilance states included active wake (AW), quiet wake (QW), slow wave sleep I (SWSI), slow wave sleep II (SWSII), and paradoxical sleep (PS). All rats received normal saline acting as their own controls. Different rats received alpha-MSH in doses of 0.05, 0.5, 1.0, 2.0, and 6.0 microg or ACTH in doses of 0.5, 1.0, and 2.0 microg. Administered alpha-MSH caused an increase in waking behavior and prolongation of sleep latency, while ACTH stimulated waking behavior and fragmented sleep, yielding more AW and less SWSII and PS. Both hormones increased periodic movements during sleep. When administered centrally in rat, alpha-MSH and ACTH stimulate motor activity in wake, cause changes in sleep architecture, and increase periodic movements in sleep. These melanocortin hormones may play a role in the pathogenesis of RLS.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?

Koo

Feng

Dostal³

2008

Movement Disorders

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“…During the course of in vivo studies on the lipolytic effect of /3-MSH in the rabbit (6), we observed that the mobilization of free fatty acids (FFA) was accompanied by lymphopenia. ACTH is known to cause lymphopenia in rabbit, rat and man, and the mechanism has been shown to be ACTH-^release of glucocorticoids by adrenal cortex->cytolytic effect of glucocorticoids on lymphocytes (7).…”

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confidence: 99%

Effect of Porcine Beta Melanocyte-Stimulating Hormone on Blood Lymphocyte Count and Serum Corticosterone Concentration of the Rabbit

et al. 1970

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Beta MSH is known to lack lipolytic or corticotropic activity in the rat. In intact rabbits, the injection of 10-100 ng purified porcine /3-MSH not only elevated serum free fatty acid (FFA) concentration 2 hr later, but also caused a reduction in blood lymphocyte count and a marked increase in serum corticosterone concentration. The effects of 10 and 100 ng (8-MSH on blood lymphocytes, serum FFA and serum corticosterone were similar in magnitude to those produced by 10 and 100 tig oxycellulose-purified ACTH. Lipolytic assays showed the ACTH preparation to be active on rat and hamster adipose tissues at a concentration of 0.01 Mg/ml, and the /3-MSH preparation to be inactive at 10 pg/ml. In the hypophysectomized rat 0.15 ng of the ACTH preparation depleted adrenal ascorbic acid content, while 500 Mg of the /3-MSH preparation had no effect. Therefore, the /3-MSH preparation contained less than 0.03% ACTH. These data suggest that /3-MSH may possess substantial corticotropic activity in the rabbit. (Endocrinology 86: 1410(Endocrinology 86: , 1970

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Effect of β-lipotropin derivatives on drinking and food behavior of rats

Котов¹,

Martynov²,

Толпыго³

et al. 1984

Bull Exp Biol Med

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Changes in Plasma or Serum Concentrations of Magnesium, Iron and Thyroxine, in Leukocyte Triglyceride Content, and in Peritoneal Fluid Protein Concentration in Rabbits Injected with Adrenocorticotropin orβMelanocyte-Stimulating Hormone

Cited by 11 publications

References 2 publications

α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?

α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?

Effect of Porcine Beta Melanocyte-Stimulating Hormone on Blood Lymphocyte Count and Serum Corticosterone Concentration of the Rabbit

Effect of β-lipotropin derivatives on drinking and food behavior of rats

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