Changes in plasma levels of lipids and lipoprotein composition in patients with Kawasaki disease

Chiang, An-Na; Hwang, Betau; Shaw, Gwo Chyuan; Lee, B.C.; Lu, Jen Her; Meng, C. C.Laura; Chou, Paula J.

doi:10.1016/s0009-8981(96)06502-3

Cited by 24 publications

(16 citation statements)

References 26 publications

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“…Other lipid profiles did not show any difference among three groups. Because we detected lipid profiles in acute phase and LDL-C level was decreased, which is compatible result of Chiang et al15) However, there are some reports that LDL-C level is higher in patients with KD than controls 9)13). These studies were done in subacute phase of KD13) and the mean age was higher than our study (7.6 year old vs. 2.68 year old) 9).…”

Section: Discussionsupporting

confidence: 87%

“…Several reports suggested that the patients with coronary arterial lesions have the lower serum levels of total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), and apo A-I, A-II and B than those of patients without coronary arterial lesions during the acute stages of KD 10)12). While low density lipoprotein-cholesterol (LDL-C) or Triglyceride (TG) are controversial among studies 9)13-15). Taken together with the previous findings, if the inflammatory processes are vigorous, the endothelial functions of gallbladder could be decreased due to inflammatory changes of GB, pathologic bile duct proliferations or inflammatory cell interactions.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Gallbladder Distension and Lipid Profiles in Kawasaki Disease

Kim

Chun

et al. 2010

Korean Circ J

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Background and ObjectivesKawasaki disease (KD) is an acute systemic vasculitis in children which causes coronary arterial dilatation (CAD) and gallbladder distension (GBD). There is a dearth of investigating the relationship between the severity of KD and GBD with lipid profiles.Subjects and MethodsA total of 80 patients with 'complete KD' who were diagnosed from January 2005 to May 2009 was enrolled in this study. Serum cholesterol {total, high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C)}, triglyceride (TG), complete blood count, inflammation markers {erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)} were measured at the time of admission during febrile period. Echocardiography and abdominal sonogram were performed in all patients to determine CAD and gallbladder size. According to GBD, patients with KD were classified as patients with GBD and patients without GBD. Between two groups, demographic and clinical data were analyzed.ResultsThe serum level of LDL-C was significantly lower in patients with GBD (p=0.03) compared with patients without GBD or febrile control. There was no significant difference in inflammatory indices between patients with GBD and patients without GBD. GBD was not significant risk factor of CAD in this study (odds ratio=2.0, 95% confidence interval=0.82-5.3, p=0.16).ConclusionThis is the first study that highlights the relationship between the GBD and lipid metabolism in patients with KD. This study provides clinical insights about potential mechanism underpinning the relationship between the GBD and lipid metabolism.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Relationship Between Gallbladder Distension and Lipid Profiles in Kawasaki Disease

Kim

Chun

et al. 2010

Korean Circ J

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“…This enzyme resides on the capillary walls of most tissues and functions at the luminal surface of the vascular endothelium (Eckel 1989). This observation is confirmed, at least in part, in later studies on the lipid derangement in KD (Cheung et al 2004;Chiang et al 1997;Cabana et al 1997). The results showed that during the acute phase, the concentrations of plasma HDL-C, apoA-I, and apoA-II were significantly reduced and the reduction of HDL was mainly related to the lowering of esterified and unesterified cholesterol in HDL2 (Chiang et al 1997).…”

Section: Vasculitissupporting

confidence: 65%

Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions

Montecucco

Favari

Norata

et al. 2014

High Density Lipoproteins

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The cholesterol of high-density lipoproteins (HDLs) and its major proteic component, apoA-I, have been widely investigated as potential predictors of acute cardiovascular (CV) events. In particular, HDL cholesterol levels were shown to be inversely and independently associated with the risk of acute CV diseases in different patient populations, including autoimmune and chronic inflammatory disorders. Some relevant and direct anti-inflammatory activities of HDL have been also recently identified targeting both immune and vascular cell subsets. These studies recently highlighted the improvement of HDL function (instead of circulating levels) as a promising treatment strategy to reduce inflammation and associated CV risk in several diseases, such as systemic lupus erythematosus and rheumatoid arthritis. In these diseases, anti-inflammatory treatments targeting HDL function might improve both disease activity and CV risk. In this narrative review, we will focus on the pathophysiological relevance of HDL and apoA-I levels/functions in different acute and chronic inflammatory pathophysiological conditions.

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“…It is known that a number of infl ammatory disorders, such as systemic vasculitis, Kawasaki disease, and Behcet's disease, are associated with low HDL, endothelial dysfunction, and pro-atherogenic gene expression (54)(55)(56)(57). Endothelial dysfunction can also occur in diabetes ( 58 ) and hypertension ( 59 ), and it is often also associated with decreased HDL-C ( 60,61 ).…”

Section: Effect Of Hfhc Diet On Expression Of Habca1 and Endogenous Gmentioning

confidence: 99%

Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis

Vaisman

Demosky

Stonik

et al. 2012

Journal of Lipid Research

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Changes in plasma levels of lipids and lipoprotein composition in patients with Kawasaki disease

Cited by 24 publications

References 26 publications

Relationship Between Gallbladder Distension and Lipid Profiles in Kawasaki Disease

Relationship Between Gallbladder Distension and Lipid Profiles in Kawasaki Disease

Impact of Systemic Inflammation and Autoimmune Diseases on apoA-I and HDL Plasma Levels and Functions

Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis

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